Surgical management of HIV related retinal detachment

Charteris, David G.

doi:10.1136/bjo.81.3.177

Cited by 6 publications

(3 citation statements)

References 21 publications

(24 reference statements)

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“…This may bias previous studies towards high T lymphocyte levels; however, even small numbers of T lymphocytes may potentially play a part in the proliferative response leading to PVR membrane formation. 28 Overall, the findings of this study suggest that T lymphocytes are a minor and infrequent component of PVR membranes and are not markedly increased by the presence of silicone oil. The absence of B lymphocytes in both PVR membranes and silicone oil membranes suggests that humoral immune responses do not play a major part in the wound healing response resulting in PVR membrane formation, or in the response to the presence of silicone oil.…”

Section: Discussionmentioning

confidence: 59%

Immunopathology of intraocular silicone oil: retina and epiretinal membranes

Wickham

Asaria

Luthert³

et al. 2007

British Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 59%

Immunopathology of intraocular silicone oil: retina and epiretinal membranes

Wickham

Asaria

Luthert³

et al. 2007

British Journal of Ophthalmology

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“…85,106,110 Findings are confounded by key treatment differences such as aciclovir monotherapy, ART, and intravitreal injections. Surgical repair of the retinal detachment with vitrectomy and silicone oil tamponade may benefit select patients, 117 however final acuities remain poor despite anatomical success. 85,86 Spontaneous reattachment of small peripheral detachments near atrophic retina have been reported rarely and is thought to be due to small self-sealing holes with underlying functional RPE.…”

Section: Diagnosismentioning

confidence: 99%

Viral retinitis: diagnosis and management in the era of biologic immunosuppression: A review

Lightman

Tomkins-Netzer

2019

Clinical Exper Ophthalmology

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Necrotising retinitis is a rare ocular infection that historically led to high rates of visual morbidity. While acute retinal necrosis occurs in immunocompetent patients, the majority of cases are associated with immunocompromise such as in cytomegalovirus retinitis and progressive outer retinal necrosis. This review summarises the clinical and diagnostic features, management, and outcomes of herpetic retinitis. Iatrogenic immunosuppression is increasingly being utilised for a wide range of indications, and biologic agents especially so due to their targeted nature. While the intended actions are well‐studied, the flow‐on effects and complex interaction with host immunity are not well understood. Furthermore, biologics are frequently used concomitantly with other immunosuppressive agents, potentiating the immunodepression. This article reviews the literature on biologic immunosuppression and viral retinitis, and presents an approach to the vulnerable or affected patient. Early identification, prompt and aggressive treatment, and a multidisciplinary approach to managing immunodeficiency are the cornerstones of management.

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“…Though good efficacy of gas tamponade with an encircling scleral buckle has been shown in a previous study with almost 83% success rate, the total cohort was very small (six eyes). Primary vitrectomy still remains the treatment option of choice [ 5 , 6 ]. Due to the inherent drawbacks of silicone oil in situ like hyperopic shift and cataractogenesis, silicone oil removal (SOR) is desirous in these cases at an optimal time [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Results of silicone oil removal in post-cytomegalovirus retinitis-related retinal detachment

Dave

Mathai

Pappuru

2012

J Ophthal Inflamm Infect

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PurposeThe purpose of this study is to evaluate the results of silicone oil removal (SOR) in post-cytomegalovirus (CMV) retinitis-related retinal detachment in Indian eyes.MethodsA retrospective review of CMV retinitis-related retinal detachment following SOR was conducted.ResultsOut of 60 eyes (55 patients) that had vitrectomy with silicone oil tamponade between 1995 and 2010, 11 eyes underwent SOR. There were two females and eight males, and the mean age was 41.27 ± 9.8 years. The duration between primary detachment surgery and SOR was 8.82 ± 2.56 months. The mean duration of HIV positivity was 33 ± 28.65 months (nearly 3 years). The average CD4 cell count at the time of SOR was 365 ± 85 cells/mm3. The mean best corrected pre-SOR visual acuity in logMAR was 1 ± 0.85, and the post-SOR acuity was 1.13 ± 0.67 (p = 0.69). The mean follow-up post-SOR was 7.54 ± 7.76 months. Out of the 11 eyes that underwent SOR, in 9 eyes, the retina was attached at the last follow-up. The anatomical success rate following SOR was 81.82% (9/11; CI, 59.03–100%).ConclusionThe results of this study suggest a relatively low redetachment rate following SOR in CMV retinitis-related retinal detachment.

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Surgical management of HIV related retinal detachment

Cited by 6 publications

References 21 publications

Immunopathology of intraocular silicone oil: retina and epiretinal membranes

Immunopathology of intraocular silicone oil: retina and epiretinal membranes

Viral retinitis: diagnosis and management in the era of biologic immunosuppression: A review

Results of silicone oil removal in post-cytomegalovirus retinitis-related retinal detachment

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