Surgical management of Gastrointestinal Stromal Tumours: A Single Centre Experience During the Past 17 Years

Vogelaere, Kristel De; Winkel, Nele Van De; Aerts, Maridi; Haentjens, Patrick; Spitali, C.; Loo, Ines Van; Delvaux, Georges

doi:10.1080/00015458.2014.11681003

Cited by 7 publications

(6 citation statements)

References 1 publication

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“…It has long been controversial whether anatomic site can predict GIST risk category. Some studies have established location as a risk factor for recurrence [ 9 , 10 , 22 , 23 ], while others have suggested that duodenal GISTs show earlier presentation, are smaller tumors, and have a lower NIH risk classification than small intestinal GISTs and may have a better prognosis [ 8 ]. Miki et al reported that the prognosis of duodenal GISTs is worse than non-duodenal GISTs [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Small Bowel Stromal Tumors: Different Clinicopathologic and Computed Tomography Features in Various Anatomic Sites

et al. 2015

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Gastrointestinal stromal tumors (GISTs) can present with different clinical and immunohistochemical characteristics according to different anatomic sites. The aim of this study was to compare clinicopathologic and computed tomography (CT) features of small bowel stromal tumors located in the duodenum, jejunum, and ileum. In total, 197 patients (109 male, 88 female) with small bowel GISTs were retrospectively reviewed. All tumors had definite anatomic sites in the small bowel tract with surgical confirmation. The clinicopathologic variables included age, sex, onset of symptoms, and tumor risk category. CT variables included tumor size, degree enhancement, enhancement pattern (region of necrosis), adjacent tissue involvement, lymphadenopathy, and distant metastasis. We assessed any possible differences according to different GIST site of origin. Based on tumor size and mitotic count, the risk categories in different anatomic sites did not differ significantly between duodenal and jejunal GISTs. However, high risk ileum GISTs accounted for 66.0% of ileal cases, which was higher than duodenum cases (36.8%, P = 0.002) and jejunum cases (43.9%, P = 0.004). The mean size of GISTs in the ileum was 9.77 cm, which was significantly larger than in the duodenum (7.41 cm, P = 0.043), and in the jejunum (8.14 cm, P = 0.027). On CT images, enhancement degree appeared to gradually increase from the duodenum to the ileum in the portal phase, and the enhancement pattern presented a tendency for heterogeneity. In Conclusions, the clinicopathologic and CT features of small bowel GISTs can differ according to different primary anatomic sites.

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Section: Discussionmentioning

confidence: 99%

Small Bowel Stromal Tumors: Different Clinicopathologic and Computed Tomography Features in Various Anatomic Sites

et al. 2015

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“…However, within the gastric tissue, several other types of malignancy may arise, including lymphomas, gastrointestinal stromal tumors (GIST), and neuroendocrine neoplasms (NEN). Interestingly, according to recent analyses, the clinical prognosis of patients suffering from these other types of gastric tumors is much more favorable in comparison to most individuals diagnosed with (especially advanced) gastric cancer 1 2 3 4 5 6 . Unfortunately, despite multiple research efforts being direct towards discovering the molecular, biochemical, and immunological mechanisms responsible for this phenomenon, it remains poorly understood.…”

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confidence: 99%

Evaluation of selected interleukins in patients with different gastric neoplasms: a preliminary report

Madej-Michniewicz

Budkowska

Sałata

et al. 2015

Sci Rep

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Abnormal interactions between cytokines may be an overlooked mechanism linking the development of different types of gastric neoplasms. In this study a comprehensive analysis of the systemic levels of interleukins (IL-1,IL-6, IL-8,IL-10 and IL-12) was performed in 75 patients with different gastric neoplasms (cancer, gastrointestinal stromal tumors, neuroendocrine neoplasms, lymphomas) and 40 healthy volunteers. Patients with gastric cancer (GC) have significantly higher IL-6 levels, and lower IL-8 and IL-10 concentrations, in comparison to controls and patients with other gastric neoplasms. Analogous results were observed in terms of IL-6/IL-8 and IL-6/IL-10 ratios, whose values were also higher in GC patients. In GC patients no associations were detected between the systemic levels/values of interleukins (ratios) and TNM staging. IL-6, IL-10, IL-6/IL-8 and IL-6/IL-10 ratios appeared to hold diagnostic potential in confirming/excluding the presence of GC. Their sensitivity/specificity in GC detection/exclusion was approximately 54–72%. In conclusion, disturbed systemic biochemical balance in multiple interleukins exists at the earliest stages of and appears to be specific to GC. The interleukin ratios proposed here seem to be more promising indicators of GC in humans than direct systemic levels of interleukins, and probably possess the potential to be applied as a supporting factor for techniques routinely used.

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“…Therefore, major anatomical resections are not required for a number of GISTs (33) in which case minimally invasive surgery is performed, particularly for gastric GISTs (34). The first report of a laparoscopically excised gastric GIST was published in 1992 (35), and there is evidence that the technique is effective with minimal morbidity and mortality (36). Endoscopic dissection is gaining acceptance as a new procedure for submucosal GIST and attains minimal morbidity and mortality (37).…”

Section: Discussionmentioning

confidence: 99%

An innovative procedure of laparoscope combined with endoscopy for gastrointestinal stromal tumor resection and cholecystectomy: A case report and literature review

Yan

Gai

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study reports a novel approach to laparoscopic and endoscopic cooperative surgery for gastric gastrointestinal stromal tumor (GIST) resection and cholecystectomy, and conducts a review of the associated literature. The novel surgical procedure was performed on one patient who was diagnosed with a GIST and cholecystic polypus. The GIST was resected using an insulation-tipped diathermic electrosurgical knife under the guide of an endoscope. Subsequently, a cholecystectomy was performed by inserting two more 5-mm trocars and instruments transumbilically, guided using an endoscope. The tumor and the gallbladder were exteriorized using a peroral approach and the incision lining of the stomach was sutured laparoscopically. The procedure was successfully performed and the patient experienced no discomfort during the 5-year follow-up. In conclusion, the present study demonstrates that laparoscopic and endoscopic cooperative surgery is feasible and would be an ideal choice for invisible abdominal scar surgery, in particular for multi-visceral resection.

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Surgical management of Gastrointestinal Stromal Tumours: A Single Centre Experience During the Past 17 Years

Cited by 7 publications

References 1 publication

Small Bowel Stromal Tumors: Different Clinicopathologic and Computed Tomography Features in Various Anatomic Sites

Small Bowel Stromal Tumors: Different Clinicopathologic and Computed Tomography Features in Various Anatomic Sites

Evaluation of selected interleukins in patients with different gastric neoplasms: a preliminary report

An innovative procedure of laparoscope combined with endoscopy for gastrointestinal stromal tumor resection and cholecystectomy: A case report and literature review

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