Surgical management of de novo metastatic meningioma of the spine: An underestimated issue for WHO grade II/III meningiomas

Jia, Qi; Wu, Zhipeng; Chu, Ruitong; Zhao, Chen; Wang, Ting; Zhou, Zhenhua; Xiao, Jianru; Yang, Xinghai

doi:10.1016/j.clineuro.2021.106995

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…Radical surgical resection is the mainstay of treatment of symptomatic spinal meningiomas and has been shown to improve quality of life postoperatively [122][123][124]. Despite the clear benefits of surgery, suggested indications for the use of nonsurgical treatment in the literature center on higher WHO grades, tumor recurrence, subtotal surgical resection, poor surgical candidacy due to increased risk of perioperative complications, NF2 disease, and the presence of multiple tumors [15].…”

Section: Adjuvant Therapiesmentioning

confidence: 99%

Spinal Meningiomas: A Comprehensive Review and Update on Advancements in Molecular Characterization, Diagnostics, Surgical Approach and Technology, and Alternative Therapies

Dang,

Mugge,

Awan

et al. 2024

Cancers

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Spinal meningiomas are the most common intradural, extramedullary tumor in adults, yet the least common entity when accounting for all meningiomas spanning the neuraxis. While traditionally considered a benign recapitulation of their intracranial counterpart, a paucity of knowledge exists regarding the differences between meningiomas arising from these two anatomic compartments in terms of histopathologic subtypes, molecular tumor biology, surgical principles, long-term functional outcomes, and recurrence rates. To date, advancements at the bench have largely been made for intracranial meningiomas, including the discovery of novel gene targets, DNA methylation profiles, integrated diagnoses, and alternative systemic therapies, with few exceptions reserved for spinal pathology. Likewise, evolving clinical research offers significant updates to our understanding of guiding surgical principles, intraoperative technology, and perioperative patient management for intracranial meningiomas. Nonetheless, spinal meningiomas are predominantly relegated to studies considering non-specific intradural extramedullary spinal tumors of all histopathologic types. The aim of this review is to comprehensively report updates in both basic science and clinical research regarding intraspinal meningiomas and to provide illustrative case examples thereof, thereby lending a better understanding of this heterogenous class of central nervous system tumors.

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Section: Adjuvant Therapiesmentioning

confidence: 99%

Spinal Meningiomas: A Comprehensive Review and Update on Advancements in Molecular Characterization, Diagnostics, Surgical Approach and Technology, and Alternative Therapies

Dang,

Mugge,

Awan

et al. 2024

Cancers

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“…71,81 Locations include lungs, liver, skin, subcutaneous tissue 71,81,96,97 and spinal metastasis. [98][99][100] Second, seizures, which are a challenge in all meningioma patients, are also caused by the repeated surgeries and recurrences in WHO grade 3; one must expect long-term anti-epileptic treatment and difficulties to control seizure frequency. Still, seizures have not been systematically investigated amongst WHO grade 3 patients.…”

Section: Treatment Options and Clinical Challengesmentioning

confidence: 99%

“…First, WHO grade 3 meningiomas have metastatic potential; the reported metastases rates vary widely from 6% to 43% 71,81 . Locations include lungs, liver, skin, subcutaneous tissue 71,81,96,97 and spinal metastasis 98–100 . Second, seizures, which are a challenge in all meningioma patients, are also caused by the repeated surgeries and recurrences in WHO grade 3; one must expect long‐term anti‐epileptic treatment and difficulties to control seizure frequency.…”

Section: Introductionmentioning

confidence: 99%

Malignant meningioma

Maier

2022

APMIS

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Prevalence and Influence of Frailty on Hospital Outcomes After Surgical Resection of Spinal Meningiomas

et al. 2023

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Surgical management of de novo metastatic meningioma of the spine: An underestimated issue for WHO grade II/III meningiomas

Cited by 4 publications

References 23 publications

Spinal Meningiomas: A Comprehensive Review and Update on Advancements in Molecular Characterization, Diagnostics, Surgical Approach and Technology, and Alternative Therapies

Spinal Meningiomas: A Comprehensive Review and Update on Advancements in Molecular Characterization, Diagnostics, Surgical Approach and Technology, and Alternative Therapies

Malignant meningioma

Prevalence and Influence of Frailty on Hospital Outcomes After Surgical Resection of Spinal Meningiomas

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