Surgical Management of Caroli’s Disease: Single Center Experience and Review of the Literature

Moslim, Maitham A.; Gunasekaran, Ganesh; Vogt, David; Cruise, Michael; Morris‐Stiff, Gareth

doi:10.1007/s11605-015-2918-9

Cited by 37 publications

(44 citation statements)

References 47 publications

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“…Type V CC or Carol disease, added by Todani, is characterized by multifocal segmental intrahepatic biliary ductal dilatation [14] without the evidence of extrahepatic dilatation [66]. Caroli disease is uncommon, accounting for less than 10% of cases.…”

Section: Classificationmentioning

confidence: 99%

Pediatric Choledochal Cysts: Unknowns are Decreasing

Gezer¹

2019

Pediatric Surgery, Flowcharts and Clinical Algorithms

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Choledochal cysts (CCs) are congenital cystic dilatation of extrahepatic and/ or intrahepatic bile ducts. CCs are more common in Asian population, the cause is still unknown. Although the etiology is controversial, the main elements in the natural historical emergence of the type I and type IV, which make up the majority of all types, have become clearer. The majority of CCs are diagnosed in childhood. Clinical presentation varies from jaundice in young patients to nonspecific abdominal pain in older, but morbidity increases with complications such as cholangitis, pancreatitis, perforation, hepatitis, liver failure, and malignancy in delayed diagnosed patients. MRCP is considered the current gold standard diagnostic modality that is able to accurately assess biliary anatomy. Although the treatment approach has been formed over the years, it still has not reached the last state. Eventually, the removal of the entire cyst and the reconstruction of the remaining biliary tract to drainage is the current treatment approach. But the dilemma is the way of reconstruction procedure (hepaticoduodenostomy or hepaticojejunostomy). All patients should be followed up for a long period of time, regardless of the surgery method.

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Section: Classificationmentioning

confidence: 99%

Pediatric Choledochal Cysts: Unknowns are Decreasing

Gezer¹

2019

Pediatric Surgery, Flowcharts and Clinical Algorithms

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“…Intrahepatic lithiasis could be classified in 2 types: Ectasia of Intrahepatic biliary duct withuot fibrosis (Caroli's Disease) and Obstructive dilatation of the intrahepatic bile duct secondary to ischemic stricture. Caroli's Disease (CD) is a rare congenital condition [3]. Malignancy is a complication of long e term CD, and some patients are presenting with [4] cholangiocarcinoma Methods: Between 1998 e 2016, 9 patients were operated on, 7 female and 2 male with a median age of 49,2 y.o (31 e 69).…”

Section: P201 Surgical Therapy For Hepatolithiasismentioning

confidence: 99%

Surgical therapy for hepatolithiasis

Garcia¹,

Acosta²,

Lamberto³

et al. 2019

HPB

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varying time intervals after transplant (6, 12, 24, or 36 months). Results: All 33 patients but one showed complete restitution of their portal hypertension by clearance of their varices and ascites one year after transplant. Mean platelet count increased from 94/nl (SD 62.5) before to 173/nl (SD 58.5) one year after LT. Change in splenic volume was significantly increasing over time: baseline before LT 1106.8 cm3, at 6 months-278.7 cm3, at 12 months-288.9 cm3, at 24 months-384.4 cm3, at 36 months-444.9 cm3. Using a mixed model, the observed change was most significant at 24 months p<0.0001. By 36 months, however, only 5 patients (15%) had regained normal spleen size (<314.5 cm3). Conclusion: Our study demonstrated a significant recovery of splenomegaly and thrombocytopenia after LT in cirrhotic patients.

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“…Congenital fibropolycystic diseases of the bile duct system, including choledochal cysts, Caroli's disease and Caroli's syndrome [27] confer an increased risk for the development of CCA [28] with a reported life-time risk of approximately 10% in adults [28,29]. Similar to colorectal adenoma and pancreatic intrapapillary mucinous neoplasia, a possible role of premalignant lesions for CCA is debated.…”

Section: Risk Factorsmentioning

confidence: 99%