Surgical Management of 48 Patients with Retrosternal Goiter and Tracheal Stenosis: A Retrospective Clinical Study from a Single Surgical Center

Zuo, Tao; Gao, Zhaoming; Chen, Zhiguo; Wen, Bangchun; Chen, Baojun; Zhang, Zhenfa

doi:10.12659/msm.936637

Cited by 7 publications

(7 citation statements)

References 33 publications

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“…If a CT examination indicates significant tracheal stenosis or tracheal diverticulum, patients must undergo bronchoscopy in the operating room to manage critical situations such as airway bleeding and obstruction [ 2 ]. In preoperative assessments, anesthesiologists must evaluate the cardiopulmonary function and related symptoms—like chest discomfort or breathlessness—and perform echocardiograms and pulmonary tests if required to determine the patient's surgical and anesthetic tolerance [ 3 ]. Due to the impact of airway tumors, patients may exhibit associated upper respiratory tract infections before surgery, leading to increased airway sensitivity and a heightened risk of bronchospasm and laryngospasm during intubation.…”

Section: Discussionmentioning

confidence: 99%

Anesthetic management of thyroid carcinoma invading the upper tracheal segment: A case report

Ding,

Gu,

Wang

et al. 2024

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Anesthetic management of thyroid carcinoma invading the upper tracheal segment: A case report

Ding,

Gu,

Wang

et al. 2024

International Journal of Surgery Case Reports

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“…In this project, we studied a large retrosternal goiter in an elderly patient. Giant retrosternal goiter is a specific type of thyroid tumor characterized by the growth of a goiter to the back of the sternum[ 9 - 11 ]. According to the nature and growth rate of the tumor, it can be divided into two types: benign and malignant[ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Pathological diagnosis and immunohistochemical analysis of giant retrosternal goiter in the elderly: A case report

Meng,

Wu,

et al. 2024

World J Clin Cases

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BACKGROUND Elderly giant retrosternal thyroid goiter is a rare yet significant medical condition, often presenting clinical symptoms that can be confused with other diseases, posing diagnostic and therapeutic challenges. This study aims to delve into the characteristics and potential mechanisms of this ailment through pathological diagnosis and immunohistochemical analysis, providing clinicians with more precise diagnostic and treatment strategies. CASE SUMMARY A 77-year-old male, was admitted to hospital with the chief complaint of finding a goiter in the semilunar month during physical examination, accompanied by dyspnea. Locally protruding into the superior mediastinum, the adjacent structure was compressed, the trachea was compressed to the right, and the local lumen was slightly narrowed. The patient was diagnosed with giant retrosternal goiter. Considering dyspnea caused by trachea compression, our department planned to perform giant retrosternal thyroidectomy. Immunohistochemical results: Tg (+), TTF-1 (+), Calcitonin (CT) (I), Ki-67 (+, about 20%), CD34 (-). Retrosternal goiter means that more than 50% of the volume of the thyroid gland is below the upper margin of the sternum. As retrosternal goiter disease is a relatively rare disease, once the disease is diagnosed, it should be timely surgical treatment, and the treatment is more difficult, the need for professional medical team for comprehensive treatment. CONCLUSION The imaging manifestations of giant retrosternal goiter are atypical, histomorphology and immunohistochemistry can assist in its diagnosis. This article reviews the relevant literature of giant retrosternal goiter immunohistochemistry and shows that giant retrosternal goiter is positive for Tg, TTF-1, and Ki-67.

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“…Nodular-like changes are seen microscopically in adenomatous goiter. The DNN model may misclassify normal thyroid tissue when it has a large follicular structure [ 18 , 19 ]. Therefore, adenomatous goiter in this study was not only easily misdiagnosed as adenoma but also partially misdiagnosed as the normal thyroid gland.…”

Section: Discussionmentioning

confidence: 99%

The value of deep neural networks in the pathological classification of thyroid tumors

Deng,

Li,

Feng

et al. 2023

Diagn Pathol

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Background To explore the distinguishing diagnostic value and clinical application potential of deep neural networks (DNN) for pathological images of thyroid tumors. Methods A total of 799 pathological thyroid images of 559 patients with thyroid tumors were retrospectively analyzed. The pathological types included papillary thyroid carcinoma (PTC), medullary thyroid carcinoma (MTC), follicular thyroid carcinoma (FTC), adenomatous goiter, adenoma, and normal thyroid gland. The dataset was divided into a training set and a test set. Resnet50, Resnext50, EfficientNet, and Densenet121 were trained using the training set data and tested with the test set data to determine the diagnostic efficiency of different pathology types and to further analyze the causes of misdiagnosis. Results The recall, precision, negative predictive value (NPV), accuracy, specificity, and F1 scores of the four models ranged from 33.33% to 100.00%. The area under curve (AUC) ranged from 0.822 to 0.994, and the Kappa coefficient ranged from 0.7508 to 0.7713. However, the performance of diagnosing FTC, adenoma, and adenomatous goiter was slightly inferior to other types of pathological tissues. Conclusion The DNN model achieved satisfactory results in the task of classifying thyroid tumors by learning thyroid pathology images. These results indicate the potential of the DNN model for the efficient diagnosis of thyroid tumor histopathology.

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Surgical Management of 48 Patients with Retrosternal Goiter and Tracheal Stenosis: A Retrospective Clinical Study from a Single Surgical Center

Cited by 7 publications

References 33 publications

Anesthetic management of thyroid carcinoma invading the upper tracheal segment: A case report

Anesthetic management of thyroid carcinoma invading the upper tracheal segment: A case report

Pathological diagnosis and immunohistochemical analysis of giant retrosternal goiter in the elderly: A case report

The value of deep neural networks in the pathological classification of thyroid tumors

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