Surgical management in pediatric neuroblastoma diagnosis and treatment: a 20-year, single-center experience

Spencer, Brianna L.; Patel, Akshilkumar; Cilley, Robert E.; Grant, Christa N.

doi:10.1007/s12519-021-00490-5

Cited by 3 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neuroblastoma (NB) is one of the most common developmental neoplasms of the nervous system in pediatrics [ [1] , [2] , [3] ]. It accounts for approximately 10% of pediatric tumors, affecting nearly 7.7 cases per million in Chinese children [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

TET3 gene rs828867 G>A polymorphism reduces neuroblastoma risk in Chinese children

Zhang,

Wang,

Lin

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

TET3 gene rs828867 G>A polymorphism reduces neuroblastoma risk in Chinese children

Zhang,

Wang,

Lin

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children, arising from undifferentiated neural crest cells ( 1 ). NB is commonly found in small glands on top of the kidneys and accounts for approximately 7%–10% of all childhood cancers ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

“…NB exhibits genetic, clinical, and therapeutic response heterogeneity, limiting the efficacy of current therapeutic strategies ( 5 ). Some tumors regress significantly without treatment, in other cases, the disease may appear very aggressive, with recurrence or extensive metastases, be ineffective against aggressive multi-pronged therapy, and ultimately, die of relapse or refractory metastatic disease ( 1 , 5 ). Clinically, approximately 50% of NB patients have metastatic disease at diagnosis and up to 60% will eventually relapse ( 4 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

A novel cuproptosis-related gene signature predicting overall survival in pediatric neuroblastoma patients

Yang

Bian

et al. 2022

Front. Pediatr.

View full text Add to dashboard Cite

BackgroundCuproptosis is a novel cell death pathway, and the regulatory mechanism in pediatric neuroblastoma (NB) remains to be explored. We amid to investigate cuproptosis-related genes (CRGs) and construct a novel prognostic model for NB.MethodsTo evaluate the role of CRGs on the clinical outcome of pediatric NB, the dataset of pediatric patients with NB of GSE49710 dataset was used to identify CRGs in association with patient overall survival (OS), and TARGET database was used to validate the predictive value of cuproptosis-related signature (CRG-score). The correlation between the CRG-score and the tumor microenvironment (TME), clinicopathological parameters, chemotherapy, and the response to immunotherapy was explored.ResultsOverall, 31 CRGs were associated with OS in the univariate Cox regression analysis. Then, a prognostic model incorporating 9 CRGs was established with the LASSO regression analysis, which could classify all NB patients into two CRG-score groups. The performance of the signature was verified in both internal and external validation cohorts. Multivariate analysis indicated that the CRG-score was an independent prognostic indicator, and stratification analysis still showed a high predictive ability for survival prediction. The CRG-score was associated with age, MYCN status, INSS stage, and COG risk. Additionally, the higher CRG-score group exhibited lower immune scores, immune cell infiltration, and decreased expression of immune checkpoints. Meanwhile, the CRG-score could predict the drug sensitivity of administering chemotherapeutic agents for NB patients.ConclusionsOur comprehensive analysis of cuproptosis-associated genes in NB provides a new approach for the prediction of clinical outcomes and more effective treatment strategies.

show abstract

Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children: analysis of 571 patients

He,

Cai,

et al. 2023

World J Pediatr

View full text Add to dashboard Cite

Background Surgery plays an important role in the treatment of neuroblastoma. Perioperative complications may impact the course of neuroblastoma treatment. To date, comprehensive analyses of complications and risk factors have been lacking. Methods Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and 2021. The data collected included clinical characteristics, operative details, operative complications and postoperative outcomes. Risk factors for perioperative complications of retroperitoneal neuroblastoma were analyzed. Results A total of 571 patients were enrolled in this study. Perioperative complications were observed in 255 (44.7%) patients. Lymphatic leakage (28.4%), diarrhea (13.5%), and injury (vascular, nerve and organ; 7.5%) were the most frequent complications. There were three operation-related deaths (0.53%): massive hemorrhage (n = 1), biliary tract perforation (n = 1) and intestinal necrosis (n = 1). The presence of image-defined risk factors (IDRFs) [odds ratio (OR) = 2.09, P < 0.01], high stage of the International Neuroblastoma Risk Group staging system (INRGSS) (OR = 0.454, P = 0.04), retroperitoneal lymph node metastasis (OR = 2.433, P = 0.026), superior mesenteric artery encasement (OR = 3.346, P = 0.003), and inferior mesenteric artery encasement (OR = 2.218, P = 0.019) were identified as independent risk factors for perioperative complications. Conclusions Despite the high incidence of perioperative complications, the associated mortality rate was quite low. Perioperative complications of retroperitoneal neuroblastoma were associated with IDRFs, INRGSS, retroperitoneal lymph node metastasis and vascular encasement. Patients with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.

show abstract

Surgical management in pediatric neuroblastoma diagnosis and treatment: a 20-year, single-center experience

Cited by 3 publications

References 24 publications

TET3 gene rs828867 G>A polymorphism reduces neuroblastoma risk in Chinese children

TET3 gene rs828867 G>A polymorphism reduces neuroblastoma risk in Chinese children

A novel cuproptosis-related gene signature predicting overall survival in pediatric neuroblastoma patients

Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children: analysis of 571 patients

Contact Info

Product

Resources

About