Surgical interventions (microfracture, drilling, mosaicplasty, and allograft transplantation) for treating isolated cartilage defects of the knee in adults

Gracitelli, Guilherme Conforto; Moraes, Vinícius Ynoe de; Franciozi, Carlos Eduardo da Silveira; Luzo, Marcus Vinícius Malheiros; Belloti, João Carlos

doi:10.1002/14651858.cd010675.pub2

Cited by 65 publications

(61 citation statements)

References 64 publications

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“…PoC in the rabbit model allowed evaluation of the cartilage repair potential of the GGMA 2% w/V hydrogel as compared with MFX treatment. Currently considered as a gold‐standard treatment, MFX still has limitations on what concerns the quality of the regenerated tissue, which can ultimately lead to treatment failure upon recurrence of symptoms . In this study, MFX group outcome showed formation of a thin layer of chondral tissue concurrent with subchondral bone overgrowth and an irregular surface.…”

Section: Discussionmentioning

confidence: 80%

In vitroandin vivoperformance of methacrylated gellan gum hydrogel formulations for cartilage repair*

Vilela

Correia

Morais

et al. 2018

J Biomedical Materials Res

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Methacrylated gellan gum (GGMA) formulation is proposed as a second-generation hydrogel for controlled delivery of cartilage-forming cells into focal chondral lesions, allowing immediate in situ retention of cells and 3D filling of lesion volume, such approach deemed compatible with an arthroscopic procedure. Formulation optimization was carried out in vitro using chondrocytes and adipose mesenchymal stromal/stem cells (ASCs). A proof-of-concept in vivo study was conducted using a rabbit model with induced chondral lesions. Outcomes were compared with microfracture or non-treated control. Three grading scores were used to evaluate tissue repair after 8 weeks by macroscopic, histological and immunohistochemical analysis. Intense collagen type II and low collagen type I gene and protein expression were achieved in vitro by the ASC + GGMA formulation, in light with development of healthy chondral tissue. In vivo, this formulation promoted significantly superior de novo cartilage formation compared with the non-treated group. Maintenance of chondral height and integration with native tissue was further accomplished. The physicochemical properties of the proposed GGMA hydrogel exhibited highly favorable characteristics and biological performance both in vitro and in vivo, positioning itself as an attractive xeno-free biomaterial to be used with chondrogenic cells for a cost-effective treatment of focal chondral lesions. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1987-1996, 2018.

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Section: Discussionmentioning

confidence: 80%

In vitroandin vivoperformance of methacrylated gellan gum hydrogel formulations for cartilage repair*

Vilela

Correia

Morais

et al. 2018

J Biomedical Materials Res

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show abstract

“…Скептические результаты этого метаанализа поддер-живает и более поздняя работа Кохрановского общества, опубликованная в 2016 г. Оценив данные серии исследова-ний, в которых изучались разные методы микрохирургиче-ского лечения ОА, авторы пришли к выводу о недостаточ-ном уровне доказательств эффективности АТХ [83].…”

Section: ау тологичная трансплантация хондроцитовunclassified

Osteoarthritis: Current Clinical Concept and Some Promising Therapeutic Approaches

Каратеев¹,

Лила²

2018

rsp

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“…The former employ techniques that stimulate tissue cells to form hyaline cartilage, such as the microfracture technique, perforation, abrasion arthroplasty, and biological procedures involving cell culture, such as autologous chondrocyte implantation (ACI), of the later derives the development of biocompatible three-dimensional scafolds, where chondrocytes, stem cells, or chondrocyte-like cells can be grown. The later involves mosaicplasty, such as the transplantation of autografts or allografts, which are composed of mature hyaline cartilage atached to the subchondral bone [128]. The type of treatment to be used will depend on the size of the lesion, the location, and the type of activity of the patient.…”

Section: The Eicacy and Safety Of Diferent Treatments Of Cartilage Inmentioning

confidence: 99%

Current Applications of Mesenchymal Stem Cells for Cartilage Tissue Engineering

Fuentes-Mera¹,

Camacho²,

Moncada‐Saucedo³

et al. 2017

Mesenchymal Stem Cells - Isolation, Characterization and Applications

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Articular cartilage injuries caused by traumatic/mechanical progressive degeneration result in joint pain, swelling, the consequent loss of joint function, and eventually osteoarthritis. Articular tissue possesses a poor ability to regenerate that further complicates the therapeutic approaches. Mesenchymal stem cells (MSCs) have emerged as a promising alternative treatment. Recently, it has been reported that a wide variety of strategies ranging from merely using cells in the injured area to employ biofunctional substitutes in which cells are harmonizing with scafolding and growth factors to create an engineered cartilage tissue.This chapter reviews the state-of the-art in cartilage tissue engineering focused on tissue engineering approaches designed to recapitulate the native development of cartilage and its tridimensional structure as an osteochondral unit. Since the production of hypertrophied tissue is one of the most critical challenges to overcome in chondral tissue regeneration, here we show new strategies to minimize hypertrophy in cartilage. Finally, the eicacy and safety of diferent treatments of cartilage in current clinical trials will be discussed.While the framework provides new features and beneits concerning the strategies for articular tissue regeneration, this chapter presents a set of tools to improve approaches to orthopedic regenerative medicine based on the use of MSCs.Keywords: MSCs, MSCs-subpopulations, cartilage regeneration, cartilage tissue engineering, hypertrophy © 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. IntroductionThe chondrocytes are the only cells found in cartilage. The chondrocytes demonstrate distinctive properties such as being metabolically active in order to maintain the renewal of the extracellular matrix (ECM) by synthesizing collagens, proteoglycans, hyaluronic acid, and glycoproteins. Restoration of the cartilage damage is still challenging for orthopedic medicine due to its poor ability to regenerate [1].Mesenchymal stem cells (MSCs) have potential applications in tissue engineering, and regenerative medicine represents an atractive option for repairing lesions in cartilage. Stem cellbased therapies that harmonize with tissue-engineering technologies, and biomaterials are vital for the continuous advance of cartilage regenerative medicine [2,3].Once the relationship between structure function in normal and damaged tissues is understood and the development of biological substitutes for the repair or regeneration can be reached. To develop a biological substitute, tissue engineering uses scafolds, cells, and growth factors. Each of these elements alone is able to promote tissue regeneration, but composites fabricated in combination would be more efective [4,5].The objective of the present chapter is, therefore, t...

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Surgical interventions (microfracture, drilling, mosaicplasty, and allograft transplantation) for treating isolated cartilage defects of the knee in adults

Abstract: Surgical interventions (microfracture, drilling, mosaicplasty, and allograft transplantation) for treating isolated cartilage defects of the knee in adults.

Cited by 65 publications

References 64 publications

In vitroandin vivoperformance of methacrylated gellan gum hydrogel formulations for cartilage repair*

In vitroandin vivoperformance of methacrylated gellan gum hydrogel formulations for cartilage repair*

Osteoarthritis: Current Clinical Concept and Some Promising Therapeutic Approaches

Current Applications of Mesenchymal Stem Cells for Cartilage Tissue Engineering

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