“…The exact pathophysiology of capsular contracture remains unclear, but previous studies have suggested that it is associated with chronic inflammatory factors, such as a foreign body reaction to the implant, the surface property of the implant, site of implant placement, postoperative bacterial infections, hematoma, or seroma [5,6]. Studies have examined whether inhibiting inflammatory events that cause a fibrosis is effective in preventing the capsular contracture, demonstrating that anti-inflammatory agents (e.g., calcium channel blockers), angiotensin-converting enzyme inhibitors, and leukotriene receptor antagonists (e.g., zafirlukast and montelukast) were effective in reducing the degree of capsular contracture [7][8][9][10][11].…”