Surgical Hemorrhage, Damage Control, and the Abdominal Compartment Syndrome

Hammond, Kerry L.; Margolin, David A.

doi:10.1055/s-2006-956439

Cited by 26 publications

(16 citation statements)

References 37 publications

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“…Despite their great ability for self-regulation, kidneys are extremely sensitive to hypoperfusion leading to acute renal failure [ 13 ]. Blood loss is a frequent clinical condition following a serious traumatic event or a major surgery, which may lead to ineffective tissue perfusion of vital organs (hypoperfusion), such as the kidneys [ 14 ], and consequently to nutritional and oxidative stress [ 13 ]. The markers of pre-apoptosis (cytochrome c) or apoptosis (M30 and TUNEL) were evaluated in all experimental groups.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

et al. 2018

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This work aimed to evaluate the effects on renal tissue integrity after hydroxyethyl starch (HES) 130/0.4 and Ringer's lactate (RL) administration in pigs under general anesthesia after acute bleeding. A total of 30 mL/kg of blood were passively removed from the femoral artery in two groups of Large White pigs, under total intravenous anesthesia with propofol and remifentanil. After bleeding, Group 1 (n = 11) received RL solution (25 mL/kg) and Group 2 (n = 11) received HES 130/0.4 solution (20 mL/kg). Additionally, Group 3 (n = 6) was not submitted to bleeding or volume replacement. Pigs were euthanized and kidneys were processed for histopathological and immunohistochemical analyses. Minimal to moderate glomerular, tubular, and interstitial changes, as well as papillary necrosis, were observed in all experimental groups. Pre-apoptosis and apoptosis indicators were higher in pigs that received HES 130/0.4, indicating a higher renal insult. Both HES 130/0.4 and RL administration may cause renal injury, although renal injury may be more significant in pigs receiving HES 13/0.4. Results also suggest that total intravenous anesthesia with propofol and remifentanil may cause renal injury, and this effect can be dose related.

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Section: Discussionmentioning

confidence: 99%

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

et al. 2018

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“…Unclogging of the drain tube leads to the resumption of blood flow. If the hemorrhage is still active, the drainage will be with reddish coagulable blood, drop by drop, and will be a strong indication for relaparotomy or laparoscopy [64]. In some cases, not uncommonly, the source of bleeding can be identified in the parietal trajectory of the drainage tube that intercepted a more or less important blood vessel.…”

Section: Drainages Of the Peritoneal Cavitymentioning

confidence: 99%

Postoperative Follow-Up and Recovery after Abdominal Surgery

Mogoantă¹,

Paitici²,

Mogoanta³

2021

Abdominal Surgery - A Brief Overview

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Postoperative patient care has several components: - surveillance, − prevention of complications associated with surgical disease or other preexisting comorbidities, − specific postoperative treatment of the surgical disease and its complications. While these distinctions are purely didactic, the postoperative care merges into an active surveillance with a higher level of standardization than it would seem at first glance. Computing, interpreting and integrating signs and symptoms with active search of proofs by lab tests or other paraclinical explorations highly depends on skills and dedication of the entire healthcare team. Those attributes gained through continuous theoretical preparation but validated by current practice bring added value, always in favor of the patients’ best interests. In this chapter, we propose to explore the main clinical and paraclinical means and tools that can improve the outcomes of surgical procedures for a faster and safer recovery. We will also discuss the need for different types of surgical bed drains placement and their management, the use of antibiotics and thrombotic event prophylaxis.

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“…In the presence of depleted volume or hemodynamic instability, it is important to resuscitate patients using isotonic crystalloid solutions. The volume used initially in these cases can reach 2 L. In cases of inadequate response, transfusion of packed RBCs can be considered, with a rate that depends on the hemodynamic response of the patient [10] .…”

Section: General Approach To Postoperative Gi Bleedingmentioning

confidence: 99%

“…Thus, the accurate determination of bleeding source is an essential issue to plan proper therapy, and all efforts must be made to achieve this. Other important causes that must be considered in cases of late postoperative GI bleeding include ischemia, inflammation, and/or infection [10] .…”

Section: Identification Of Disorder Contributing To the Bleeding Sourcementioning

confidence: 99%

Post-Operative Bleeding and Its Management

Ghallab

2018

Egyptian Journal of Hospital Medicine

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Background: one of the most feared complications of surgery is bleeding. Substantial gastrointestinal bleeding in the postoperative time is an unusual complication of both GI and non-GI surgery. If not managed properly and promptly, the patient can suffer from hypovolemic shock and so it is considered a life-threatening emergency until proven otherwise. Aim of the work: In this review, we aimed to study post-operative bleeding with special reference to gastrointestinal surgery and also to understand the major causes and explore the approach to its management. Methodology: we conducted this review by using a comprehensive search of MEDLINE, PubMed and EMBASE, January 2001, through February 2017. The following search terms were used: post-operative bleeding, gastrointestinal surgical hemorrhage, gastrointestinal bleeding, hypotensive shock and bleeding management. Results: immediate surgery must be performed to save the patient in case of bleeding after surgery. Conclusion: to prevent postoperative hemorrhage, thorough evaluation must be done. When bleeding occurs, it is essential to recognize it immediately as prognosis and survival are significantly affected with delayed proper management. If needed, immediate surgery must be performed to save the patient.

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Surgical Hemorrhage, Damage Control, and the Abdominal Compartment Syndrome

Cited by 26 publications

References 37 publications

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

Evaluation of renal injury caused by acute volume replacement with hydroxyethyl starch 130/0.4 or Ringer's lactate solution in pigs

Postoperative Follow-Up and Recovery after Abdominal Surgery

Post-Operative Bleeding and Its Management

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