SURGICAL GEM: A Simple Method of Tissue Embedding for Mohs Micrographic Surgery

Honda, Nathan S.; Friedman, David H.

doi:10.1111/j.1524-4725.1989.tb03409.x

Cited by 21 publications

(24 citation statements)

References 3 publications

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“…Whalen et al 7 summarized the availability of safe xylene substitutes for use in the histology laboratory. Honda and Friedman 8 reported their development of a simpler method of embedding tissue; Dogan et al 9 suggested techniques to facilitate maintenance of proper tissue planes. Similarly, advantages of the use of specialized tissue embedding devices have been described.…”

mentioning

confidence: 99%

Mohs Surgery and Processing: Novel Optimizations and Enhancements

Weber

Moody

Dryden

et al. 2000

Dermatologic Surgery

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mentioning

confidence: 99%

Mohs Surgery and Processing: Novel Optimizations and Enhancements

Weber

Moody

Dryden

et al. 2000

Dermatologic Surgery

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“…[1][2][3][4]. There are also several papers describing less commonly used methods such as the cryomold [5], Miami special [6], special discs [7], and gradual freezing with liquid nitrogen [8]. Motley and Holt [9] published results from a survey of the members of the American College of MOHS Micrographic Surgery and Cutaneous Oncology, with data on the methods used for freezing tissue.…”

Section: Discussionmentioning

confidence: 98%

Tissue preparation for MOHS’ frozen sections: a comparison of three techniques

Bakhtar

Davidson

et al. 2007

Virchows Arch

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Accurate, efficient frozen section analysis is important for tumor control. A few studies address the technical issues. More are needed, especially as new technologies become available. The objective of this study is to compare the efficiency of three techniques of flattening tissue for microscopically oriented histologic surgery (MOHS): conventional frozen sectioning, Cryocup, and CryoHist. Conventional chuck/heat sink-frozen section preparation were compared with Cryocup and CryoHist to determine the most efficient technique to examine 100% of the surgical margin of 4-cm diameter, full thickness, fresh autopsy cylinders of anterior abdominal skin, which were marked on their deep and peripheral margins. The specimens were frozen sectioned at 5 microm until all the marking dye was gone from the deep surface, and 95% of the perimeter epidermis could be seen. The conventional chuck required an average of 304 micrometers to clear the deep margin and four fifths did not contain 95% of the epidermal margin. The Cryocup required an average of 284 microm to examine the deep margin and 95% of the epidermal margin. The CryoHist required an average of 104 microm to examine the deep margin and 95% of the epidermal border. The new techniques improve the efficiency and presumably the accuracy of tumor margin analysis.

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“…Literally scores of techniques and machines have been created in the past decades to produce complete margins (Table 1). [15][16][17][18][19][20][21][22][23] Most of the mounting techniques apply force to flatten the outside margin, something largely accomplished by relaxing incisions. In our experience, two of the simpler methods, forceps placement followed by a heat extractor and the Miami Special are the most used and most useful.…”

Section: Mounting Fresh Tissuementioning

confidence: 99%