Surgical Factors Influence Bladder Cancer Outcomes: A Cooperative Group Report

Herr, Harry W.; Faulkner, John; Grossman, H. Barton; Natale, Ronald B.; White, Ralph W. deVere; Sarosdy, Michael F.; Crawford, E. David

doi:10.1200/jco.2004.11.024

Cited by 539 publications

(351 citation statements)

References 9 publications

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“…However, there are variations in outcome, even among high-volume, experienced surgeons, suggesting that surgical technique rather than experience may independently affect outcome. In a multi-institutional study, improved surgical quality (margin status and > ten lymph nodes obtained) significantly correlated with better survival than pathological stage, nodal status, patient age and chemotherapy status [11]. One expert panel went so far as to conclude that, to be considered 'proficient' at radical cystectomy, surgeons should perform at least ten radical cystectomies per year with a minimum of 10-14 nodes obtained [12].…”

mentioning

confidence: 99%

Lymph node density: surrogate marker for quality of resection in bladder cancer?

Kamat¹,

Fisher²

2007

Expert Review of Anticancer Therapy

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mentioning

confidence: 99%

Lymph node density: surrogate marker for quality of resection in bladder cancer?

Kamat¹,

Fisher²

2007

Expert Review of Anticancer Therapy

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“…3 Routine performance and extent of lymph node dissection is clearly associated with survival gains in the bladder cancer literature. 10 The large majority of radical cystectomies, however, are performed with a known diagnosis of muscle invasion (stage ≥pT2), whereas 50.3% of NU specimens in the current study were for pT1 disease, and clinical staging remains a significant preoperative challenge. Previous studies have found from 0-6% node-positivity in T1 disease, compared with 24% to 35% for T3 disease.…”

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confidence: 73%

Mining the data on UTUC management

Leveridge

2012

CUAJ

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“…It is also, for example, well known that surgical technique has a major impact on outcome in bladder cancer and therefore a nomogram based on a study population from centers of excellence may not be applicable outside these centers [2].…”

Section: Preoperative Assessment Of Pelvic Lymph Nodes Nomogramsmentioning

confidence: 99%

Indications, Extent, and Benefits of Pelvic Lymph Node Dissection for Patients with Bladder and Prostate Cancer

2009

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Target audience: Physicians who wish to advance their current knowledge of clinical cancer medicine in genitourinary cancer. LEARNING OBJECTIVES1. Evaluate all patients undergoing radical pelvic surgery to determine whether they should have pelvic lymph node dissection.2. Determine to what extent a pelvic lymph node dissection should be performed and analyze the risks involved.3. Based on best practices, assess whether pelvic lymph node dissection is beneficial for staging and prognosis.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTThe role of pelvic lymph node dissection (PLND) in both bladder and prostate cancer has recently been generating renewed interest. In an attempt to avoid PLND, both nomograms and imaging studies have been evaluated; however, so far they have shown limited success because of inadequate accuracy in staging patients. The three primary objectives of this review are: to define patients in whom PLND should be performed, to define the extent and consequences of the template for PLND, and to identify the staging and prognostic benefits seen with PLND in bladder and prostate cancer. Based on the findings from this review, we conclude that PLND for bladder cancer patients is undoubtedly beneficial, whereas it is less so for prostate cancer patients, in whom a selection strategy should be employed. PLND, in particular with an extended template, seems to provide superior accuracy for postoperative staging than the presently available imaging studies and may be pivotal when considering adjuvant therapies. Furthermore, it has an impact on survival in high-risk patients, and potentially more so in low-risk cancer patients with occult metastases.

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Surgical Factors Influence Bladder Cancer Outcomes: A Cooperative Group Report

Abstract: Surgical factors influence bladder cancer outcomes after cystectomy, after adjustment for pathologic factors and neoadjuvant chemotherapy usage.

Cited by 539 publications

References 9 publications

Lymph node density: surrogate marker for quality of resection in bladder cancer?

Lymph node density: surrogate marker for quality of resection in bladder cancer?

Mining the data on UTUC management

Indications, Extent, and Benefits of Pelvic Lymph Node Dissection for Patients with Bladder and Prostate Cancer

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