Surgical Experience With Pancreatic Islet-Cell Tumors

Abstract

This experience from a single institution underscores the role of preoperative localization studies and appropriate surgical management of these rare tumors.

A Fuller Understanding of Pancreatic Neuroendocrine Tumours Combined with Aggressive Management Improves Outcome

“…The outcome of surgery for PNETs has been shown to be significantly better than that for other forms of pancreatic malignancies [73,74] . Table 8 lists the outcomes of surgical treatment (with curative intent) for PNETs reported by a number of institutions worldwide [2,69,70,[73][74][75][76][77][78][79][80][81][82] . The ubiquitous finding in all these studies is that curative resection is associated with excellent long-term survival and symptom control.…”

Poorly Differentiated Neuroendocrine Carcinoma of the Pancreas Responsive to Combination Therapy with Gemcitabine and S-1

“…A previous study (14) reported that the most frequent preoperative diagnosis of patients with nonfunctioning pancreatic NET was pancreatic cancer, because clinical presentations and CT findings of the pancreatic tumor mimic ductal adenocarcinoma of the pancreas. Similarly, based on the findings of contrast-enhanced CT, we speculated that this patient had pancreatic cancer with multiple liver metastases.…”

Central pancreatectomy for benign tumors of the neck and body of the pancreas: Report of eight cases

“…For benign pancreatic tumors, enucleation is the first choice, although which is not always possible due to tumor size or localization [1,2]. Pancreaticoduodenectomy, with or without pylorus preservation, is frequently used in the patients with benign tumors confined to the pancreatic head.…”

“…A pancreaticoduodenectomy or distal pancreatectomy is the customary treatment for those tumors [1][2][3][4][5][6]. But these two operations are extremely cruel for benign lesions and usually carry important operative complications and potential mortality, and furthermore imply a significant waste of normal pancreatic tissue with the risk of diabetes, exocrine insufficiency, thrombosis and severe infection [7][8][9][10].…”

“…The surgical technique of central pancreatectomy (CP) was described 40 years ago for the treatment of pancreatic trauma [9,11]. In the last two decades, this technique has been successfully used to treat benign pancreatic tumors [1][2][3][4][5][6][7][8][9][10].…”