Surgical excision versus observation as initial management of desmoid tumors: A population based study

Turner, B. Weems; Alghamdi, Mohamed S.; Henning, Jan-Willem; Kurien, Elizabeth; Morris, Don; Bouchard‐Fortier, Antoine; Schiller, Dan; Puloski, Shannon; Monument, Michael J.; Itani, Doha; Mack, Lloyd A.

doi:10.1016/j.ejso.2018.09.015

Cited by 39 publications

(30 citation statements)

References 20 publications

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“…Contrary to our results, evidence supports the effect of negative margins and adjuvant radiotherapy on local recurrence [38]. Turner et al [24] suggested that negative margins should be the goal, but should not be pursued at the expense of significant functional loss. They suggested one additional consideration, namely tumor behavior [24].…”

Section: Discussioncontrasting

confidence: 99%

“…Turner et al [24] suggested that negative margins should be the goal, but should not be pursued at the expense of significant functional loss. They suggested one additional consideration, namely tumor behavior [24]. Any residual from an aggressive tumor should be presumed to be at high risk of regrowth and that negative margins are therefore more important in this group [24].…”

Section: Discussionmentioning

confidence: 99%

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Upfront surgery is not advantageous compared to more conservative treatments such as observation or medical treatment for patients with desmoid tumors

Tsukamoto

Tanzi

Mavrogenis

et al. 2021

BMC Musculoskelet Disord

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Background This study compared the clinical and functional outcomes of patients initially treated with observation or medical treatment with those of patients treated with local treatment (surgery alone or surgery with adjuvant radiotherapy) to confirm whether observation or medical treatment is an appropriate first-line management approach for patients with desmoid tumors. Methods We retrospectively reviewed the medical records of 99 patients with histologically confirmed primary desmoid tumors treated between 1978 and 2018. The median follow-up period was 57 months. We evaluated event-free survival, defined as the time interval from the date of initial diagnosis to the date of specific change in treatment strategy or recurrence or the last follow-up. Results An event (specific change in treatment strategy or recurrence) occurred in 28 patients (28.3%). No significant difference in event-free survival was found between the first-line observation/medical treatment and local treatment groups (p = 0.509). The median Musculoskeletal Tumor Society score of the patients treated with first-line local treatment was 29 (interquartile range [IQR], 23–30), whereas that of the patients managed with first-line observation or medical treatment was 21 (IQR, 19–29.5). First-line observation or medical treatment was more frequently chosen for larger tumors (p = 0.045). In the patients treated with local treatment, local recurrence was not related to the surgical margin (p = 0.976). Conclusion Upfront surgery is not advantageous compared to more conservative treatments such as observation or medical treatment for patients with desmoid tumors.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Upfront surgery is not advantageous compared to more conservative treatments such as observation or medical treatment for patients with desmoid tumors

Tsukamoto

Tanzi

Mavrogenis

et al. 2021

BMC Musculoskelet Disord

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“…The CTV was defined as equal to the GTV and was irradiated with a total dose of 60 Gy (RBE)/30 fr. surgical margin and local control rate [6,14,15]. Treatment is particularly challenging for an aggressive H&N desmoid tumor because complete resection is difficult.…”

Section: Discussionmentioning

confidence: 99%

Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature review

SAWADA

Mizumoto

Oshiro

et al. 2021

Clinical and Translational Radiation Oncology

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Section: General Therapeutic Strategymentioning

confidence: 99%

“…The strongest factors predicting DT recurrence after surgery are represented by tumor size and site and patient age [ 24 , 25 , 26 ]. Among sites, abdominal DT have decreased recurrence rates after surgery compared to extra-abdominal locations [ 24 , 25 , 26 ]. The impact of microscopic margin positivity on tumor relapse is not clear, as it was not found to be predictor of a worse local control in some series [ 24 , 25 , 27 , 28 ], while being associated in others [ 19 , 29 ].…”

Section: General Therapeutic Strategymentioning

confidence: 99%

Recent Advances in Desmoid Tumor Therapy

Napolitano

Mazzocca

Ceruso

et al. 2020

Cancers

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The desmoid tumor is a locally aggressive proliferative disease within the family of soft-tissue sarcomas. Despite its relatively good prognosis, the clinical management of desmoid tumors requires constant multidisciplinary evaluation due to its highly variable clinical behavior. Recently, active surveillance has being regarded as the appropriate strategy at diagnosis, as indolent persistence or spontaneous regressions are not uncommon. Here, we review the most recent advances in desmoid tumor therapy, including low-dose chemotherapy and treatment with tyrosine kinase inhibitors. We also explore the recent improvements in our knowledge of the molecular biology of this disease, which are leading to clinical trials with targeted agents.

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Surgical excision versus observation as initial management of desmoid tumors: A population based study

Cited by 39 publications

References 20 publications

Upfront surgery is not advantageous compared to more conservative treatments such as observation or medical treatment for patients with desmoid tumors

Upfront surgery is not advantageous compared to more conservative treatments such as observation or medical treatment for patients with desmoid tumors

Long-term follow up of a patient with a recurrent desmoid tumor that was successfully treated with proton beam therapy: A case report and literature review

Recent Advances in Desmoid Tumor Therapy

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