Surgical Excision of Primary Canine Rectal Tumors by an Anal Approach in Twenty‐Three Dogs

Danova, Nichole A.; Robles-Emanuelli, Juan Carlos; Bjorling, Dale E.

doi:10.1111/j.1532-950x.2006.00154.x

Cited by 40 publications

(56 citation statements)

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“…Adenomatous polyps and adenocarcinoma are observed as solitary masses in the rectum, and most polyps appear as friable, lobulated, sessile, or pedunculated lesions on the mucosa. Surgical resection has been recommended in dogs as treatment for colorectal polyps [2,5,21]. Endoscopic treatment for adenomatous polyps [7,10] and piroxicam for tubulopapillary polyps [15] have been reported as alternative therapies for colorectal neoplasms.…”

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confidence: 99%

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

Ohmi

Tsukamoto

Ohno

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Medical records of dogs with colorectal polyps were retrospectively reviewed, and clinical presentation of inflammatory colorectal polyps in miniature dachshunds was evaluated. Of 33 dogs found to have colorectal polyps, miniature dachshunds were markedly over-represented with 16 dogs (48%), of which 12 (75%) were found to have inflammatory polyps. Multiple polyps localized between the rectum and the descending colon was the most common finding in miniature dachshunds with inflammatory polyps. Twenty dogs (80%) out of 25 miniature dachshunds with inflammatory colorectal polyps responded to immunosuppressive therapy using prednisolone and cyclosporine. The results of this study indicate that miniature dachshunds are predisposed to develop inflammatory colorectal multiple polyps, for which immunosuppressive therapy may be a treatment option. Polyps are an abnormal growth of tissue arising from the mucosa, including neoplasms and inflammatory polyps. In dogs, colorectal polyps are relatively common in the gastrointestinal tract. These polyps can be single or multiple and are most often located in the distal rectum, causing the common clinical signs of hematochezia or tenesmus. In previous reports, many colorectal polyps in dogs were found to be derived from neoplasms, with adenomatous polyps and adenocarcinoma being most frequently represented [11,25,32,33]. Adenomatous polyps and adenocarcinoma are observed as solitary masses in the rectum, and most polyps appear as friable, lobulated, sessile, or pedunculated lesions on the mucosa. Surgical resection has been recommended in dogs as treatment for colorectal polyps [2,5,21]. Endoscopic treatment for adenomatous polyps [7,10] and piroxicam for tubulopapillary polyps [15] have been reported as alternative therapies for colorectal neoplasms. On the contrary, inflammatory colorectal polyps are rare, and few reports have described the clinical features of inflammatory colorectal polyps [33]. In humans, inflammatory colorectal polyps or polypoid lesions occur in association with inflammatory bowel disease (IBD) and other inflammatory diseases of the colon such as ischemic or infective colitis [3,17,24]. These masses form mainly due to extensive mucosal damage and healing processes, rather than infiltration of inflammatory cells. The polyps formed from infiltration of inflammatory cells, which could be termed "true" inflammatory polyps, seem to be relatively rare in humans.This study was conducted on the basis of two objectives. First, we retrospectively investigated dogs with colorectal polyps to characterize the prevalence and clinical features of the disease in Japan. Second, we reviewed the clinical presentation and treatment response of cases with inflammatory colorectal multiple polyps in miniature dachshunds, which were markedly over-represented in our study. MATERIALS AND METHODS Retrospective study of colorectal polyps in dogs:We reviewed the medical records of 33 dogs found to have colorectal polyps at the Veterinary Medical Center of the University of...

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confidence: 99%

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

Ohmi

Tsukamoto

Ohno

et al. 2012

The Journal of Veterinary Medical Science

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“…In the case of severe tenesmus, tumours in the rectum may be everted outward. The above, described clinical signs in patients were also noted in the studies by Danova et al (2006), Terragni et al (2006) and Morello et al (2008). Tumours in the large intestine can be of various forms.…”

Section: Discussionmentioning

confidence: 53%

“…Terragni et al (2006) described four cases of an adenocarcinoma of the large intestine -two in Collies, one in German shepherd and one in mixed-breed dog. However, in the study by Danova et al (2006), none of the seven dogs were from predisposed breeds.…”

Section: Discussionmentioning

confidence: 99%

“…The surgical removal of the lesions prolonged the survival time by seven to nine months compared to untreated animals. Danova et al (2006) studied the survival time after a surgical removal of rectal neoplastic lesions in dogs (observation until the animal's death or completion of the study). They reported that there were no relapses in dogs with rectal adenocarcinomas from 21 to 84 months post-surgery.…”

Section: Discussionmentioning

confidence: 99%

“…They may protrude into the intestinal lumen or may infiltrate the intestinal wall, leading to a constriction of the lumen (Willard 2005, Sapierzyński 2006, Selting 2013. The clinical signs of neoplastic lesions in the large intestine include the presence of blood in the stool, obstructed defecation, painful defecation and tenesmus (Danova et al 2006, Terragni et al 2006, Morello et al 2008.…”

Section: Introductionmentioning

confidence: 99%

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Adenocarcinoma of the posterior segment of the gastrointestinal tract in dogs – clinical, endoscopic, histopathological and immunohistochemical findings

Spużak¹,

Ciaputa²,

Kubiak³

et al. 2017

Polish Journal of Veterinary Sciences

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Of all the tumours in dogs, three percent are located in the intestines, and 36-60% of those tumours affect the large intestine. Adenocarcinomas of the intestines account for 20-35% of the gastrointestinal tumours and for almost 60% of the large intestine tumours. The aim of the study was to analyze clinical disorders and endoscopic, histopathological and immunohistochemical changes in colorectal adenocarcinomas in dogs with the use of the E-cadherin, β-catenin, cytokeratin 20 (CK20), Ki-67 and minichromosome maintenance 3 (MCM-3). The study comprised 11 dogs of both genders and of different breeds diagnosed with adenocarcinoma of the large intestine. They were from 4 to 11 years old.The large intestine adenocarcinoma was diagnosed in all the patients. 72.7% cases were diagnosed with a rectal adenocarcinoma, and 27.3% were found to have a colonic adenocarcinoma. All the studied proteins were expressed at different levels and, together with the histological findings, indicated different levels of malignancy (G). The statistical analysis revealed no statistically significant differences between the expression of E-cadherin and β-catenin in the studied tissues (p=0.79) and between the expression of Ki-67 and MCM-3 (p=0.39). A strong positive correlation was found between the expression of E-cadherin and β-catenin (r=0.86; p<0.05).The diagnosis of adenocarcinomas of the large intestine may be facilitated by the introduction of immunohistochemical studies using appropriate cell markers. They may also aid in the accurate evaluation of the biological character of the tumours, their origin, the connections between tumour cells and the mitotic index. That, in turn, may help determine the malignancy and the choice of treatment.

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