Surgical Dressings and Novel Skin Substitutes

Axibal, Eileen; Brown, Mariah

doi:10.1016/j.det.2019.03.005

Cited by 23 publications

(20 citation statements)

References 66 publications

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“…Irrespective of the type of wound, the main function of dressings is to aid in the repair of the wound through the reduction of pain and inflammation, to protect the damaged tissue from pathogenic agents, and to enhance cell differentiation and proliferation [3]. Although there several types of dressings which are commercially available, many of these present some drawbacks, such as an inefficient absorption of exudates, poor protection against infections by microbes, the lack of ability to maintain humidity, and the triggering of allergic effects [4].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

et al. 2019

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Non-biodegradable materials with a low swelling capacity and which are opaque and occlusive are the main problems associated with the clinical performance of some commercially available wound dressings. In this work, a novel biodegradable wound dressing was developed by means of alginate membrane and polycaprolactone nanoparticles loaded with curcumin for potential use in wound healing. Curcumin was employed as a model drug due to its important properties in wound healing, including antimicrobial, antifungal, and anti-inflammatory effects. To determine the potential use of wound dressing, in vitro, ex vivo, and in vivo studies were carried out. The novel membrane exhibited the diverse functional characteristics required to perform as a substitute for synthetic skin, such as a high capacity for swelling and adherence to the skin, evidence of pores to regulate the loss of transepidermal water, transparency for monitoring the wound, and drug-controlled release by the incorporation of nanoparticles. The incorporation of the nanocarriers aids the drug in permeating into different skin layers, solving the solubility problems of curcumin. The clinical application of this system would cover extensive areas of mixed first- and second-degree wounds, without the need for removal, thus decreasing the patient’s discomfort and the risk of altering the formation of the new epithelium.

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Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

et al. 2019

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“…It naturally possesses antibacterial activity, promotes drainage, avoids the production of exudates and allows gas exchange [17,88]. Alginate is obtained from seaweed; it is highly absorbent and biodegradable [93]. These materials could be engineered to produce a wide range of biomedical devices, but very often are used in form of hydrogel, and due to their high biocompatibility and ability to absorb liquids, they have been extensively employed in wound healing applications [45,88].…”

Section: Absorbable Natural Materialsmentioning

confidence: 99%

“…Allograft and xenografts are obtained by dermis decellularization in order to remove cells from the tissue, leaving just the organized collagen architecture (ECM) and producing a structure that can be generally called ADM [10]. These types of matrices have been very often used in hernia [18], PFDs [108], BR [100] and wound-healing applications [93] aiming to reach an integration level of the prosthesis with the native tissue with minimal or nonnegative response. Some of the most common source of ADM are rectus fascia, fascia lata [109], human dermis, porcine dermis and porcine small intestine submucosa (SIS) [3].…”

Section: Graftsmentioning

confidence: 99%

“…Aside from dermal substitutes, epidermal grafts have also been used for wound-healing applications. While the use of ADM requires a pre-decellularization of the dermis, using epidermal substitutes requires keratinocytes expansion and cultivation [93]. Even if there are reported advantages related to the use of grafts, such as rapid host revascularization and cell repopulation [10], there are also several drawbacks, which include limitations related to the donor site and tissue harvesting, and post-surgery pain in the case of autografts, possibility to develop infections and prion disease in the case of allografts and xenografts [108,110].…”

Section: Graftsmentioning

confidence: 99%

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Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

2021

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Surgical meshes have been employed in the management of a variety of pathological conditions including hernia, pelvic floor dysfunctions, periodontal guided bone regeneration, wound healing and more recently for breast plastic surgery after mastectomy. These common pathologies affect a wide portion of the worldwide population; therefore, an effective and enhanced treatment is crucial to ameliorate patients’ living conditions both from medical and aesthetic points of view. At present, non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia, pelvic floor dysfunctions and guided bone regeneration, with polypropylene and poly tetrafluoroethylene being the most common. Biological prostheses, such as surgical grafts, have been employed mainly for breast plastic surgery and wound healing applications. Despite the advantages of mesh implants to the treatment of these conditions, there are still many drawbacks, mainly related to the arising of a huge number of post-operative complications, among which infections are the most common. Developing a mesh that could appropriately integrate with the native tissue, promote its healing and constructive remodelling, is the key aim of ongoing research in the area of surgical mesh implants. To this end, the adoption of new biomaterials including absorbable and natural polymers, the use of drugs and advanced manufacturing technologies, such as 3D printing and electrospinning, are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical practice. The aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes, the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations. Graphic abstract

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“…Collagen dressings are capable of counterbalancing the elevated levels of matrix metalloproteinases which are usually released at the wound site and proteolytically deteriorate native intact and partially degraded fragments of collagen molecules. Currently, collagen is coupled with other natural and synthetic polymers, e.g., salmon milt DNA, anionic polysaccharides, minocycline based hydrogels, α-tocopherulate, and alginic acid, for developing novel dually functional collagen-based wound dressings that combine both wound healing and exudate absorbing properties [ 127 , 129 , 130 ].…”

Section: Wound Dressings In Skin Cancermentioning

confidence: 99%

Regenerative Wound Dressings for Skin Cancer

Pavel

Chircov

Rădulescu

et al. 2020

Cancers

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Skin cancer is considered the most prevalent cancer type globally, with a continuously increasing prevalence and mortality growth rate. Additionally, the high risk of recurrence makes skin cancer treatment among the most expensive of all cancers, with average costs estimated to double within 5 years. Although tumor excision is the most effective approach among the available strategies, surgical interventions could be disfiguring, requiring additional skin grafts for covering the defects. In this context, post-surgery management should involve the application of wound dressings for promoting skin regeneration and preventing tumor recurrence and microbial infections, which still represents a considerable clinical challenge. Therefore, this paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described.

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Surgical Dressings and Novel Skin Substitutes

Cited by 23 publications

References 66 publications

Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

Regenerative Wound Dressings for Skin Cancer

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