Surgical delay and mortality for primary cutaneous melanoma

Guhan, Samantha; Boland, Genevieve M.; Tanabe, Kenneth K.; Lin, William M.; Reddy, Bobby Y.; Hawryluk, Elena B.; Sober, Arthur J.

doi:10.1016/j.jaad.2020.07.078

Cited by 13 publications

(10 citation statements)

References 4 publications

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“…6 In patients with stage I to stage III melanoma, a delay of more than 2 months from diagnosis to final surgical management compared to patients treated within 2 months of diagnosis leads to significantly worse survival. 7 Similarly, a delay of more than 30 days from biopsy to surgery is associated with poorer survival for patients with early melanoma [8][9] . A study that used the melanoma growth rate (ROG) to estimate the effect of the COVID-19 lockdown on melanoma thickness and prognosis showed that the diagnostic delay determines an upstaging in the T of melanoma and consequently a worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…During the first wave COVID‐19 pandemic, there has been a decrease in patient screening in melanoma and other types of cancer 5 . The lockdown circumstances resulting in inadequate melanoma care conditions could increase the number of advanced stage melanoma cases and healthcare expenses 6 . In patients with stage I to stage III melanoma, a delay of more than 2 months from diagnosis to final surgical management compared to patients treated within 2 months of diagnosis leads to significantly worse survival 7 .…”

Section: Discussionmentioning

confidence: 99%

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Management of melanoma patients during COVID‐19 pandemic in an Italian skin unit

Filoni

Fiore

Cappellesso

et al. 2021

Dermatologic Therapy

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Due to the COVID‐19 crisis, many scheduled medical and surgical activities have been suspended. This interruption to the healthcare system can negatively affect the diagnosis and management of melanoma. Neglecting melanoma throughout the outbreak may be associated with increased rates of mortality, morbidity, and healthcare expenses. We performed a retrospective review of all dermatological and surgical activity performed in our Melanoma Skin Unit between 23 February 2020 and 21 May 2020 and compared these data with those from the same period in 2019. During the lockdown period, we observed a decrease in dermatologic follow‐up (DFU) (−30.2%) and in surgical follow‐up (SFU) (−37%), and no modification of melanoma diagnosis (−3%). Finally, surgical excisions (SE) (+ 31.7%) increased, but sentinel lymph node biopsy (SLNB) (−29%) and lymph node dissections(LND) (−64%) decreased compared to the same period in 2019. Our experience supports the continuation of surgical and diagnostic procedures in patients with melanoma during the COVID‐19 pandemic. Surgical and follow‐up procedures for the diagnosis and treatment of melanoma should not be postponed considering that the pandemic is lasting for an extended period.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Management of melanoma patients during COVID‐19 pandemic in an Italian skin unit

Filoni

Fiore

Cappellesso

et al. 2021

Dermatologic Therapy

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“…One review of several studies, which addressed the outcomes on melanoma survival following the surgical delay recommended by the NCCN, revealed contradictory evidence. 12 Further, sufficiently powered studies will be needed to better understand the impact of delaying treatment during the summer COVID-19 surge on patients with skin cancer. Therefore, physicians must triage patients accordingly to manage and treat while also preventing disease spread.…”

Section: Practice Pointsmentioning

confidence: 99%

Skin Cancer Management During the COVID-19 Pandemic

Thomas

Rossi

2020

Cutis

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“…Melanoma is a type of malignant skin cancer, and its incidence rate has increased rapidly in recent decades [ 1 , 2 , 3 ]. The melanoma incidence rate in Canada is 122.9 cases per million person a year [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Integration of lncRNAs, Protein-Coding Genes and Pathology Images for Detecting Metastatic Melanoma

Liu

Fan

et al. 2022

Genes

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Melanoma is a lethal skin disease that develops from moles. This study aimed to integrate multimodal data to predict metastatic melanoma, which is highly aggressive and difficult to treat. The proposed EnsembleSKCM method evaluated the prediction performances of long noncoding RNAs (lncRNAs), protein-coding messenger genes (mRNAs) and pathology images (images) for metastatic melanoma. Feature selection was used to screen for metastatic biomarkers in the lncRNA and mRNA datasets. The integrated EnsembleSKCM model was built based on the weighted results of the lncRNA-, mRNA- and image-based models. EnsembleSKCM achieved 0.9444 in the prediction accuracy of metastatic melanoma and outperformed the single-modal prediction models based on the lncRNA, mRNA and image data. The experimental data suggest the importance of integrating the complementary information from the three data modalities. WGCNA was used to analyze the relationship of molecular-level features and image features, and the results show connections between them. Another cohort was used to validate our prediction.

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Surgical delay and mortality for primary cutaneous melanoma

Cited by 13 publications

References 4 publications

Management of melanoma patients during COVID‐19 pandemic in an Italian skin unit

Management of melanoma patients during COVID‐19 pandemic in an Italian skin unit

Skin Cancer Management During the COVID-19 Pandemic

Integration of lncRNAs, Protein-Coding Genes and Pathology Images for Detecting Metastatic Melanoma

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