Surgical Correction of a Sacral Meningomyelocele in a Dog

Song, Rachel B.; Glass, Eric N.; Kent, Marc; Sánchez, Melissa D.; Smith, Diana M.; Lahunta, Alexander de

doi:10.5326/jaaha-ms-6090

Cited by 14 publications

(16 citation statements)

References 17 publications

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“…Sporadic occurrence has been described in calves (21) and less frequently in other species (1,3,21). Different forms of spinal dysraphism such as meningocele or meningomyelocele can be associated with other neural tube malformations in dogs (3,11,17,18) and cats (14). Here we describe the first case of a lipomeningocele and spina bifida associated with diplomyelia in a dog.…”

Section: Discussionmentioning

confidence: 81%

“…The incidence of lipomyelomeningoceles is 0.57 per 10 000 life births in man (4). In veterinary medicine lipomyelomeningoceles and lipomeningoceles are rare conditions (3,18,20) and there are only a few case reports of meningomyelocele or split cord malformations in dogs (1,11,16,17) and cats (12,14). A particular form has been described in Manx cats, characterized by sacrocaudal dysgenesis (12).…”

Section: Discussionmentioning

confidence: 99%

“…Those techniques include in particular primary closure and exogenous graft material (7,9,10,20). Similar techniques have been used in animals (11,14,(16)(17)(18). The dural repair line can be a source of retethering if the spinal cord becomes adherent to the healing suture line (7).…”

Section: Discussionmentioning

confidence: 99%

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Lipomeningocele associated with diplomyelia in a dog

Schulze¹,

Ondreka²,

Laws³

et al. 2018

Tierarztl Prax Ausg K

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SummaryA 2-year-old male neutered mixed breed dog with a body weight of 30 kg was presented for evaluation of a soft subcutaneous mass on the dorsal midline at the level of the caudal thoracic spine. A further clinical sign was intermittent pain on palpation of the area of the subcutaneous mass. The owner also described a prolonged phase of urination with repeated interruption and re-initiation of voiding. The findings of the neurological examination were consistent with a lesion localization between the 3rd thoracic and 3rd lumbar spinal cord segments. Magnetic resonance imaging revealed a spina bifida with a lipomeningocele and diplomyelia (split cord malformation type I) at the level of thoracic vertebra 11 and 12 and secondary syringomyelia above the aforementioned defects in the caudal thoracic spinal cord. Surgical resection of the lipomeningocele via a hemilaminectomy was performed. After initial deterioration of the neurological status postsurgery with paraplegia and absent deep pain sensation the dog improved within 2 weeks to non-ambulatory paraparesis with voluntary urination. Six weeks postoperatively the dog was ambulatory, according to the owner. Two years after surgery the owner recorded that the dog showed a normal gait, a normal urination and no pain. Histopathological diagnosis of the biopsied material revealed a lipomeningocele which confirmed the radiological diagnosis.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Lipomeningocele associated with diplomyelia in a dog

Schulze¹,

Ondreka²,

Laws³

et al. 2018

Tierarztl Prax Ausg K

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“…Moderate to severe forms of NTD, such as SBO with MMC or MC, are typically diagnosed in young animals. Although a congenital anomaly may be seen in any breed, certain breeds have been overrepresented with spina bifida occulta such as the English bulldogs Wilson et al, 1979;Fingeroth et al, 1989, Brunetti et al, 1993Ployart et al, 2013) and the German shepherd dogs (Clayton, 1983;Song et al, 2014). A meningocoele has also been described in a Collie (Wilson et al, 1979) (Figure 3).…”

Section: Sbo With Meningocoele (Mc) Meningomyelocoele (Mmc)mentioning

confidence: 99%

“…The simplest form of CSD is dorsal spina bifida and is usually clinically insignificant, with no or minor neural anomalies (Figure 2). Occasionally, a subcutaneous mass may be present in SBO, which consists of a meningocele Wilson et al, 1979;Gómez et al, 2012;Song et al, 2014). Another form of SBO are dermal sinus tracts (Miller andTobias, 2003, Kiviranta et al, 2011;Song et al, 2016).…”

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confidence: 99%

Aangeboren afwijkingen van de wervels bij de hond

Rycke¹,

Saunders²

2017

Vlaams Diergeneeskundig Tijdschrift

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In this review article, a overview is given of the congenital pathologies of vertebrae in the dog. These pathologies are common in dogs and can be divided in two major groups: neural tube defects or spinal dysraphism, such as spina bifida with or without meningocoele and dermal sinus tract, and congenital anomalies of the vertebral column. The latter group can be subdivided in malformations originating in the embryonic period of development, such as butterfly vertebra, mediolateral wedged vertebra and transitional vertebra, or in the foetal period, such as block vertebra and dorsoventral wedged vertebra. Congenital vertebral anomalies can be incidental findings on radiographs or CT, but sometimes they can be the underlying cause of a clinical, mostly neurological problem. Due to pressure on the spinal cord, symptoms, such as pelvic limb ataxia, paresis, loss of spinal reflexes, incontinence and atrophy of the pelvic limbs may occur.

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Comparison of inherited neural tube defects in companion animals and livestock

Zarzycki

Thomas

Mazrier

2020

Birth Defects Research

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Neural tube defects (NTDs) are congenital malformations resulting from the improper or incomplete closure of the neural tube during embryonic development. A number of similar malformations of the protective coverings surrounding the central nervous system are also often included under this umbrella term, which may not strictly fit this definition. A range of NTD phenotypes exist and have been reported in humans and a wide range of domestic and livestock species. In the veterinary literature, these include cases of anencephaly, encephalocele, dermoid sinus, spina bifida, and craniorachischisis. While environmental factors have a role, genetic predisposition may account for a significant part of the risk of NTDs in these animal cases. Studies of laboratory model species (fish, birds, amphibians, and rodents) have been instrumental in improving our understanding of the neurulation process. In mice, over 200 genes that may be involved in this process have been identified and variant phenotypes investigated. Like laboratory mouse models, domestic animals and livestock species display a wide range of NTD phenotypes. They remain, however, a largely underutilized population and could complement already established laboratory models. Here we review reports of NTDs in companion animals and livestock, and compare these to other animal species and human cases. We aim to highlight the potential of nonlaboratory animal models for mutation discovery as well as general insights into the mechanisms of neurulation and the development of NTDs.

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Surgical Correction of a Sacral Meningomyelocele in a Dog

Cited by 14 publications

References 17 publications

Lipomeningocele associated with diplomyelia in a dog

Lipomeningocele associated with diplomyelia in a dog

Aangeboren afwijkingen van de wervels bij de hond

Comparison of inherited neural tube defects in companion animals and livestock

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