Surgical considerations in a paediatric case of a large skull-base epithelioid haemangioendothelioma

Ooi, Suyi; Gutman, Matthew; Xenos, Chris; Chandra, Ronil V.; McLean, Catriona

doi:10.1007/s00381-018-3988-2

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…Due to the paucity of cases, behavior can often be difficult to predict, but local invasion and occasional metastasis have been reported. 71 In the veterinary literature, there are but 2 reported cases of mass lesions occurring in the brain for which the term hemangioendothelioma was used: a 9-year-old dog and a 5-month-old calf. 24,117 Remarkably, these 2 cases both showed epithelioid and spindle cell hemangioendothelioma differentiation.…”

Section: Hemangioendotheliomamentioning

confidence: 99%

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A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

et al. 2020

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In disease, blood vessel proliferation has many salient roles including in inflammation, when granulation tissue fills superficial defects, or in the recanalization of an occluded blood vessel. Sometimes angiogenesis goes awry—granulation can be exuberant, and plexiform proliferation of vascular components can contribute to pulmonary hypertension. This review focuses on the diverse manifestations of pathologic vascular overgrowth that occur in the brain, spinal cord, and meninges of animals from birth until old age. Entities discussed include systemic reactive angioendotheliomatosis in which glomeruloid vascular proliferations are encountered in various organs including the central nervous system (CNS). The triad of CNS vascular malformations, hamartomas, and benign vascular proliferations are an especially fraught category in which terminology overlap and the microscopic similarity of various disorders makes diagnostic classification incredibly challenging. Pathologists commonly take refuge in “CNS vascular hamartoma” despite the lack of any unique histopathologic features and we recommend that this diagnostic category be abandoned. Malformative lesions that are often confusing and have similar features; the conditions include arteriovenous malformation, cavernous angioma, venous angioma, and capillary telangiectases. Meningioangiomatosis, a benign meningovascular proliferation with dual components, is a unique entity seen most commonly in young dogs. Last, accepted neoplastic conditions range from lower-grade locally acquired growths like hemangioblastoma (a tumor of mysterious interstitial stromal cells encountered in the setting of abundant capillary vasculature proliferation), the rare hemangioendothelioma, and the highly malignant and invariably multifocal metastatic hemangiosarcoma. Additionally, this review draws on the comparative medical literature for further insights into this problematic topic in pathology.

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Section: Hemangioendotheliomamentioning

confidence: 99%

“…Due to the paucity of cases, behavior can often be difficult to predict, but local invasion and occasional metastasis have been reported. 71…”

Section: Neoplastic Disordersmentioning

confidence: 99%

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

et al. 2020

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“…[96] A review of the literature revealed 61 cases of primary intracranial EHE [Table 2]. [2,3,6,7,9,10,16,18,23,26,27,29,30,33,35,38,40,43,45,47,53,54,57,59,[62][63][64][65][66][67][68][70][71][72][73]76,79,[82][83][84][85][86]89,92,94,95,98,99,101,104,105] ere is a wide age range (31 weeks gestation-74 years ...…”

Section: Discussionmentioning

confidence: 99%

Dural composite hemangioendothelioma: The first intracranial case

Liu,

Bauer,

Lin

et al. 2024

Surgical Neurology International

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Background: Composite hemangioendothelioma (CHE) is a rare, locally aggressive neoplasm of intermediate malignant potential. It is composed of a mixture of vascular tumors with a predilection for the dermis and subcutis of the extremities. Case Description: In this report, we describe a 41-year-old man who presented with a 2-month history of headache, dizziness, and intermittent seizures. Magnetic resonance imaging showed a hemorrhagic, multilobulated, and dural-based mass with extension into the calvarium. The mass measured 10.3 × 4.8 × 4 cm along the interhemispheric fissure and encased the superior sagittal sinus. Excision was performed, and histopathologic examination revealed a heterogeneous mixture of vascular components consisting of epithelioid hemangioendothelioma, retiform hemangioendothelioma, and hemangioma. This is the first report of a primary intracranial CHE. Conclusion: The spectrum of mesenchymal neoplasms within the cranium expands to encompass CHE.

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Surgical considerations in a paediatric case of a large skull-base epithelioid haemangioendothelioma

Cited by 2 publications

References 25 publications

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

Dural composite hemangioendothelioma: The first intracranial case

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