Surgical Complications of Shigellosis in Children

Miron, Dan; Sochotnick, Igor; Yardeni, Dan; Kawar, Bassem; Siplovich, L.

doi:10.1097/00006454-200009000-00022

Cited by 18 publications

(15 citation statements)

References 12 publications

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“…In particular, when Shigella infection is combined with intestinal perforation, appendicitis and peritonitis, clinical manifestations of abdominal infection, such as high fever and septicemia, may occur with a high mortality rate (11). It was reported that 13 out of 57 children with surgical complications of Shigellosis died, despite having received antimicrobial therapy (12). In addition to the clinical reports, animal experiments have shown that diarrhea symptoms disappear within 24 h after oral infection with Shigella, while persistent diarrhea symptoms and mortality occur after intraperitoneal injection of Shigella (13).…”

Section: Introductionmentioning

confidence: 99%

Dynamic comparison of gut microbiota of mice infected with Shigella�flexneri via two different infective routes

Yang

Chen²,

Xia³

et al. 2020

Exp Ther Med

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Shigella is one of the main pathogens causing diarrheal disease, and is associated with high morbidity and mortality in developing countries. Previous clinical data and animal studies have shown that the outcomes of oral and peritoneal infections of Shigella differ, and that the latter is more serious. Furthermore, a variety of pathogenic bacteria are known to cause changes in intestinal flora after infection, and the influence of Shigella infection on intestinal flora remains poorly understood. In the present study, the 16S rRNA high-throughput sequencing method was used to compare the changes in gut microbiota profiles in feces of mice infected with Shigella via two routes. In addition, the present study investigated the association between the differences in infection performance and bacterial communities. The present results suggested that the intraperitoneal route induced a distinct decrease in α-diversity in the fecal microbiota when compared to the control at a later time, while the effect of the oral route on α-diversity was not obvious. Oral infection of Shigella had a rapid and significant effect on gut microbiota, mainly causing a decreased abundance of Lactobacillus and an increased abundance of Prevotella and Escherichia/Shigella in the early stage of infection. By contrast, the effect of intraperitoneal infection on the gut microbiota was relatively slow and small. The principal coordinate analysis results suggested that the dynamic profile of gut microbiota between the two infective routes was consistent with the infection process. Probiotics, such as Lactobacillus reuteri and Faecalitalea exhibited significantly reduced abundance after Shigella infection. Collectively, the present results suggested that gut microbiota may play a pivotal role in the pathogenesis of Shigella infection. Future studies should investigate the effect of Shigella infection on the interaction between pathogenic bacteria and intestinal flora. The present results suggested that the use of probiotics may facilitate the prevention and treatment of shigellosis.

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Section: Introductionmentioning

confidence: 99%

Dynamic comparison of gut microbiota of mice infected with Shigella�flexneri via two different infective routes

Yang

Chen²,

Xia³

et al. 2020

Exp Ther Med

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“…Toxic megacolon, colonic perforation, appendicitis with or without perforation, intra-abdominal abscesses, and intestinal obstruction were the reported surgical complications that are related to Shigella infection (2,7). In one series of 173 autopsied cases of shigellosis, perforation was found post-mortem in three cases.…”

Section: Discussionmentioning

confidence: 99%

“…Perforation has been most commonly reported in neonates or severely malnourished children and may occur with either S. dysenteriae type 1 or S. flexneri infection (7). All the reported cases of Shigella peritonitis have been secondary to appendicitis, colonic obstruction, or transmural colitis leading to colonic perforation (2,3). In our patient, Shigella peritonitis developed secondary to perforated appendicitis.…”

Section: Discussionmentioning

confidence: 99%

“…In literature, there are few reports of gangrenous appendicitis and localized peritonitis, associated with Shigella spp. gastroenteritis in pediatric and adult patients (2,3,(12)(13)(14)(15)(16). Interestingly, our patient did not have diarrhea.…”

Section: Discussionmentioning

confidence: 99%

“…There are few reported cases of perforated appendicitis complicated with peritonitis due to Shigella spp. (2,3). We report a case of perforated appendicitis and severe peritonitis that is related to S. sonnei infection.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Unusual Presentation of Shigellosis: Acute Perforated Appendicitis and Peritonitis

Bayhan¹,

Tanır²,

Maden³

et al. 2015

J Pediatr Inf

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Shigella spp. gelişmekte olan ülkelerde bakteriyel ishal ve dizanterinin en sık etkenidir. Şigellozisin klinik bulguları hafif ishalden ciddi dizanteriye kadar değişen geniş bir klinik yelpaze göstermektedir. Beş buçuk yaşında daha önce sağlıklı olan erkek hasta karın ağrısı, kusma ve kabızlık ile başvurmuştu. Fizik muayenede sağ alt kadranda hassasiyet saptandı. Hastaya akut apendisit tanısı ile açık apendektomi işlemi yapıldı. Abdominal kavitenin cerrahi olarak açılması ile perfore apendisit ve yaygın peritonit tespit edildi. Peritoneal sıvı kültüründe Shigella sonnei üredi. Hasta komplikasyon gelişmeksizin tam olarak iyileşti. Şigellozisin seyri sırasında apendisitte dahil olmak üzere cerrahi komplikasyonlar gelişebilmektedir. Literatürde Shigella ilişkili perfore apendisit olgusu oldukça az sayıda bildirilmiştir. Erken cerrahi girişim morbidite ve mortaliteyi önlemde yararlıdır.

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Abdominal Symptom Complexes

Kotloff¹

2023

Principles and Practice of Pediatric Infectious Diseases

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Surgical Complications of Shigellosis in Children

Cited by 18 publications

References 12 publications

Dynamic comparison of gut microbiota of mice infected with Shigella�flexneri via two different infective routes

Dynamic comparison of gut microbiota of mice infected with Shigella�flexneri via two different infective routes

Unusual Presentation of Shigellosis: Acute Perforated Appendicitis and Peritonitis

Abdominal Symptom Complexes

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