Surgical complications and long-term survival after esophagectomy for cancer in a nationwide Swedish cohort study

Rutegård, Martin; Lagergren, Pernilla; Rouvelas, Ioannis; Mason, Robert C.; Lagergren, Jesper

doi:10.1016/j.ejso.2012.02.177

Cited by 123 publications

(107 citation statements)

References 28 publications

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“…have concluded that surgical complications might be independent predictors of poor long‐term survival in patients undergoing esophageal cancer resection, including patients who survived the postoperative period 31, 32. This large, population‐based, nationwide cohort study has shown that re‐operation within 30 days of primary esophageal resection is associated with increased mortality, even when the initial 3 months after surgery is excluded.…”

Section: Resultsmentioning

confidence: 99%

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Shimada

Fukagawa

Haga

et al. 2017

Annals of Gastroent Surgery

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PurposeThe impact of postoperative complications on survival after radical surgery for esophageal, gastric, and colorectal cancers remains controversial. We conducted a systematic review of recent publications to examine the effect of postoperative complications on oncological outcome.MethodsA literature search of PubMed/MEDLINE was performed using the keywords “esophageal cancer,” “gastric cancer,” and “colorectal cancer,” obtaining 27 reports published online up until the end of April 2016. Articles focusing on (i) postoperative morbidity and oncological outcome; and (ii) body mass index (BMI), postoperative morbidity, and oncological outcome, were selected. Univariate and multivariate analyses (Cox proportional hazards model) were performed.ResultsPatients with postoperative complications had significantly poorer long‐term survival than those without complications. Complications were associated with impaired oncological outcomes. The hazard ratios for overall survival were 1.67 (95% confidence interval [CI], 1.31‐2.12), 1.59 (95% CI, 1.13‐2.24), and 1.55 (95% CI, 1.28‐1.87) in esophageal, gastric, and colorectal cancers, respectively. High BMI was associated with postoperative morbidity rate but not with poor oncological outcome. Low BMI was significantly associated with inferior oncological outcome.ConclusionsComplications after radical surgery for esophageal, gastric, and colorectal cancers are associated with patient prognosis. Avoiding such complications might improve the outcomes.

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Section: Resultsmentioning

confidence: 99%

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Shimada

Fukagawa

Haga

et al. 2017

Annals of Gastroent Surgery

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“…Of the five studies that excluded early mortality from the analysis or performed analysis with and without this subgroup, only one reported a convincing association. The one remaining study by Rutegard et al failed to identify an association on univariate analysis, P=0.409 but noted a weakly positive multivariate analysis, with a hazard ratio of 1.3 [11]. This coupled with the evidence from the current study suggests that, if there is an association between postoperative complications and early cancer relapse, the magnitude of the effect is at best small.…”

Section: Discussionmentioning

confidence: 53%

“…Since then, a further 12 reports have evaluated the relationship between postoperative complications and cancer survival after esophagogastric resection [1,[5][6][7][9][10][11][12]16,[18][19][20][21] (Table 2). Many of the studies included early postoperative mortality in the analysis.…”

Section: Discussionmentioning

confidence: 99%

“…A number of smaller studies have examined the potential relationship between perioperative outcome and cancer relapse [4][5][6][7][8][9][10][11][12][13][14][15][16], in patients undergoing esophagogastric resection. The findings have been conflicting, with seven of 13 studies reporting a significantly poorer longterm survival for those suffering postoperative complications compared to their counterparts, while six studies failed to identify a significant difference in survival.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Postoperative Morbidity on Longterm Cancer Survival after Esophagogastric Resection

S¹

2014

J Gastroint Dig Syst

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Background: Previous studies have shown that postoperative adverse events after colorectal resection predict a poor prognosis with early cancer relapse. The aim of this study was to report the outcome of patients undergoing esophagogastric resection to assess the influence of in-hospital factors on long-term cancer survival. Specifically, a standardized definition of complications was applied to this cohort and mortalities within the first 90 days were excluded from the analysis in order to remove any bias this would have.

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“…This is higher than previous Norwegian figures (8 -30 %) and on a par with the results for patients who received neoadjuvant radiochemotherapy in a Dutch multicentre study (47 %) (19 -23). Survival was also higher than in an English study (27 %) and a Swedish study (21 %) (30,10). The proportion who received neoadjuvant therapy in these two studies was lower than the proportion in the Ullevål dataset (17 % and 5 % compared with 60 %).…”

Section: Discussionmentioning

confidence: 58%

Reseksjon for oesophaguscancer – komplikasjoner og overlevelse

Grøtting¹,

Løberg²,

Johannessen³

et al. 2016

Tidsskriftet

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MAIN POINTSOutcomes for hybrid oesophageal section were no post-operative mortality, a low proportion of serious complications and good five-year survival There is a growing tendency for minimally invasive procedures in the surgical treatment of oesophageal cancer BACKGROUND Surgery is regarded as necessary for achieving a cure with oesophageal cancer. Minimally invasive procedures are increasingly being employed in oesophageal resection, with the aim of achieving fewer complications than with open surgery. The purpose of this study was to investigate post-operative complications, mortality and long-term survival after hybrid oesophageal resection by means of laparoscopy and thoracotomy.

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Surgical complications and long-term survival after esophagectomy for cancer in a nationwide Swedish cohort study

Cited by 123 publications

References 28 publications

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Influence of Postoperative Morbidity on Longterm Cancer Survival after Esophagogastric Resection

Reseksjon for oesophaguscancer – komplikasjoner og overlevelse

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