Surgical clips vs. iodine-125 (125I) seeds for marking the location of nonpalpable malignant breast lesions: preliminary results

Arnau, Inmaculada Mendoza; Sánchez, R. Sánchez; Casas, M. Culiañez; Aguirre, A.C. Rebollo; Jiménez, Ángela Conchillo; Meca, S. Martínez

doi:10.1016/j.rxeng.2019.08.002

Cited by 3 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, lumbosacral fusion might narrow the hip joint space and increase the risk of hip osteoarthritis, especially the patients with long-segment lumbosacral fusion [40]. Radiotherapy using 125 I seeds implanted between tissues has developed rapidly in recent years and has become a typical example of the best conformal treatment [41,42]. 125 I seed implantation was reported in 239 patients with T1-T2 prostate cancer, and with 5-year and 10-year survival rates of 74% and 66%, respectively [43].…”

Section: Discussionmentioning

confidence: 99%

Prognostic analysis of percutaneous vertebroplasty (PVP) combined with 125I implantation on lumbosacral vertebral osteoblastic metastases

Xu,

Huang,

Lou

et al. 2023

World J Surg Onc

View full text Add to dashboard Cite

Objective Lumbosacral vertebral osteoblastic metastasis is treated with percutaneous vertebroplasty (PVP) combined with 125I seed implantation and PVP alone. Compared to PVP alone, we evaluated the effects of combination therapy with PVP and 125I seed implantation on pain, physical condition, and survival and evaluated the clinical value of PVP combined with 125I particle implantation. Methods We retrospectively analyzed 62 patients with lumbosacral vertebral osseous metastases treated at our hospital between 2016 and 2019. All the patients met the inclusion criteria for 125I implantation, and they were randomly divided into a combined treatment group and a pure PVP surgery group. The visual analog pain scale (VAS), Karnofsky Performance Status (KPS), and survival time were recorded at different time points, including preoperative, postoperative 1 day, 1 month, 3 months, 6 months, 12 months, and 36 months in each group. The variation in clinical indicators and differences between the groups were analyzed using SPSS version 20.0. Correlations between different variables were analyzed using the nonparametric Spearman’s rank test. The Kaplan–Meier method was used to estimate the relationship between survival time and KPS score, VAS score, or primary tumor progression, and survival differences were analyzed using the log-rank test. Multivariate analyses were performed using a stepwise Cox proportional hazards model to identify independent prognostic factors. Results Compared to the PVP treatment group, the pain level in the combined treatment group was significantly reduced (P = 0.000), and the patient’s physical condition in the combination treatment group significantly improved. Kaplan–Meier analysis showed that the survival rate of the PVP group was significantly lower than that of the combination group (P = 0.038). We also found that the median survival of patients in both groups significantly increased with an increase in the KPS score (14 months vs. 33 months) (P = 0.020). Patients with more than three transfer sections had significantly lower survival rates than those with one or two segments of the section (P = 0.001). Further, Cox regression analysis showed that age (P = 0.002), the spinal segment for spinal metastasis (P = 0.000), and primary tumor growth rate (P = 0.005) were independent factors that affected the long-term survival of patients with lumbosacral vertebral osseous metastases. Conclusions PVP combined 125I seeds implantation surgery demonstrated superior effectiveness compared to PVP surgery alone in treating lumbosacral vertebral osseous metastases, which had feasibility in the clinical operation. Preoperative KPS score, spine transfer section, and primary tumor growth rate were closely related to the survival of patients with lumbosacral vertebral osteoblastic metastasis. Age, spinal segment for spinal metastasis, and primary tumor growth can serve as prognostic indicators and guide clinical treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic analysis of percutaneous vertebroplasty (PVP) combined with 125I implantation on lumbosacral vertebral osteoblastic metastases

Xu,

Huang,

Lou

et al. 2023

World J Surg Onc

View full text Add to dashboard Cite

show abstract

“…Reoperation rates were reported by 27 studies [29,35,[38][39][40][41][42][44][45][46][47][48][49][50][51][52][53][54][55][56][57][60][61][62][63][64][65][66][67]69,70], with a relevant heterogeneity (I 2 = 61%). The reoperation risk after conservative surgery with RSL was lower than with WGL (RR = 0.71, 95% CI = 0.61-0.84; 13884 patients; 27 studies; see Figure 8).…”

Section: Reoperationmentioning

confidence: 99%

“…The complications rates related to marker implantation were reported by 25 studies [30,[33][34][35][41][42][43][44][45][46][47][48][49][50][51][52]55,57,60,61,64,[67][68][69][70], with a relevant heterogeneity (I 2 = 57%). The complications risk in conservative surgery with WGL was lower than with RSL, but this value was not statistically relevant (RR = 1.12, 95% CI = 0.66-1.78; 8672 patients; 25 studies; see Figure 11).…”

Section: Complicationsmentioning

confidence: 99%

“…Post-operative complication rates were reported by 13 studies [29,31,32,41,42,44,48,51,60,61,[64][65][66], without heterogeneity (I 2 = 0%). The post-operative complications risk after conservative surgery with WGL was lower than with RSL, but this value was not statistically relevant (RR = 1.17, 95% CI = 0.90-1.52; 5525 patients; 13 studies; see Figure 12).…”

Section: Complicationsmentioning

confidence: 99%

“…The time interval between localization and surgery was reported by 25 studies [30,33,34,[39][40][41][42][43][44][45][47][48][49][50]52,53,55,56,60,61,64,66,67,69,70], totaling 10455 patients (RSL = 4895; WGL = 5560). However, due to missing data it was not possible to perform statistical synthesis.…”

Section: Time Between Localization and Surgerymentioning

confidence: 99%

See 2 more Smart Citations

Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis

Ferreira,

de Souza,

Pozzo

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Background: This study is a systematic review with meta-analysis comparing radioactive seed localization (RSL) versus radio-guided occult lesion localization (ROLL) and wire-guided localization (WGL) for patients with impalpable breast cancer undergoing breast-conserving surgery and evaluating efficacy, safety, and logistical outcomes. The protocol is registered in PROSPERO with the number CRD42022299726. Methods: A search was conducted in the Embase, Lilacs, Pubmed, Scielo, Web of Science, and clinicaltrials.gov databases, in addition to a manual search in the reference list of relevant articles, for randomized clinical trials and cohort studies. Studies selected were submitted to their own data extraction forms and risk of bias analysis according to the ROB 2 and ROBINS 1 tools. A meta-analysis was performed, considering the random effect model, calculating the relative risk or the mean difference for dichotomous or continuous data, respectively. The quality of the evidence generated was analyzed by outcome according to the GRADE tool. Overall, 46 articles met the inclusion criteria and were included in this systematic review; of these, 4 studies compared RSL and ROLL with a population of 1550 women, and 43 compared RSL and WGL with a population of 19,820 women. Results: The results showed that RSL is a superior method to WGL in terms of surgical efficiency in the impalpable breast lesions’ intraoperative localization, and it is at least equivalent to ROLL. Regarding security, RSL obtained results equivalent to the already established technique, the WGL. In addition to presenting promising results, RSL has been proven to be superior to WGL and ROLL technologies.

show abstract

Comparative analysis between radioactive seed localization and wire-guided for non-palpable breast cancer surgery

Ferreira

Zeituni²,

Rigo³

et al. 2022

Braz. J. Rad. Sci.

View full text Add to dashboard Cite

The conservative surgery for impalpable breast cancer requires an intraoperative localization method that guides the identification and correct excision of the lesion. The aim of this study is to comparatively analyze two intraoperative breast localization technologies, wire guided localization (WGL) and radioactive seed localization (RSL), regarding their surgical efficacy through the outcomes of surgical margins, intraoperative re-excision, reoperation and recurrence. To this end, a systematic search was realized in databases for clinical trials that match with the study eligibility criteria. The selected studies were evaluated for their methodological quality; the data were then collected and quantitatively synthesized. The results comprised thirty-eight studies that match the eligibility criteria. The main outcomes reported demonstrating that the RSL is at least equivalent to the WGL in efficiency rates. These results confirm the method applicability for impalpable breast lesions surgery in an effective way, in addition to presenting organizational optimization of radiology and surgery services by allowing the surgery to be performed up to two months after seed implantation.

show abstract

Surgical clips vs. iodine-125 (125I) seeds for marking the location of nonpalpable malignant breast lesions: preliminary results

Cited by 3 publications

References 19 publications

Prognostic analysis of percutaneous vertebroplasty (PVP) combined with 125I implantation on lumbosacral vertebral osteoblastic metastases

Prognostic analysis of percutaneous vertebroplasty (PVP) combined with 125I implantation on lumbosacral vertebral osteoblastic metastases

Radioactive Seed Localization for Nonpalpable Breast Lesions: Systematic Review and Meta-Analysis

Comparative analysis between radioactive seed localization and wire-guided for non-palpable breast cancer surgery

Contact Info

Product

Resources

About