Surgical Atlas. Primary hypospadias repair with buccal mucosa

Stein, Raimund; Schröder, Annette; Thüroff, Joachim W.

doi:10.1111/j.1464-410x.2006.06119.x

Cited by 17 publications

(3 citation statements)

References 20 publications

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“…Autologous free tissue grafts have been used clinically for urethral reconstruction, including skin from genital and extra-genital regions, 7,8 with buccal mucosa the most commonly used. [9][10][11] Problems most commonly associated with the use of autologous free tissue grafts include graft size, donor site morbidity and graft contracture. 12 Preclinical studies aimed at improving hypospadias repair outcomes by applying novel biomaterials and tissue-engineering techniques have met limited success (reviewed 2 ).…”

Section: Introductionmentioning

confidence: 99%

Augmentation of the insufficient tissue bed for surgical repair of hypospadias using acellular matrix grafts: A proof of concept study

et al. 2021

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Acellular matrices produced by tissue decellularisation are reported to have tissue integrative properties. We examined the potential for incorporating acellular matrix grafts during procedures where there is an inadequate natural tissue bed to support an enduring surgical repair. Hypospadias is a common congenital defect requiring surgery, but associated with long-term complications due to deficiencies in the quality and quantity of the host tissue bed at the repair site. Biomaterials were implanted as single on-lay grafts in a peri-urethral position in male pigs. Two acellular tissue matrices were compared: full-thickness porcine acellular bladder matrix (PABM) and commercially-sourced cross-linked acellular matrix from porcine dermis (Permacol™). Anatomical and immunohistological outcomes were assessed 3 months post-surgery. There were no complications and surgical sites underwent full cosmetic repair. PABM grafts were fully incorporated, whilst Permacol™ grafts remained palpable. Immunohistochemical analysis indicated a non-inflammatory, remodelling-type response to both biomaterials. PABM implants showed extensive stromal cell infiltration and neovascularisation, with a significantly higher density of cells ( p < 0.001) than Permacol™, which showed poor cellularisation and partial encapsulation. This study supports the anti-inflammatory and tissue-integrative nature of non-crosslinked acellular matrices and provides proof-of-principle for incorporating acellular matrices during surgical procedures, such as in primary complex hypospadias repair.

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Section: Introductionmentioning

confidence: 99%

Augmentation of the insufficient tissue bed for surgical repair of hypospadias using acellular matrix grafts: A proof of concept study

et al. 2021

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“…Так, в качестве одномоментной методики коррекции рекомендуют тубуляризированный (заранее) трансплантат слизистой щеки, который анастомозируют с гипоспадическим меатусом [58]. Возможно применение слизистой щеки в качестве onlay на сохраненную уретральную площадку, так же как при одномоментной пластике уретры [59]. В качестве альтернативы слизистой щеки предлагается слизистая нижней поверхности языка [60] либо слизистая мочевого пузыря [61], в 1-м случае как вариант операции Bracka, во 2-м -как тубуляризированный трансплантат.…”

Section: новые технологииunclassified

Hypospadias repair in children: fundamental principles and latest tendencies

Суров¹,

Kagantsov²

2017

Androl. genit. hir.

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В статье содержится анализ литературы, посвященной вопросам лечения гипоспадии у детей. Проводятся параллели между классическими трудами и современными тенденциями в лечении данного порока развития половых органов. Описаны новые хирургические методики (с отсылкой к истории их появления) и разработки. Ведется дискуссия об использовании одномоментных и этапных хирургических вмешательств при проксимальной гипоспадии, приводится анализ литературных данных об осложнениях, сопутствующих применению той или иной техники. Описываются новые варианты классификации гипоспадии, методы оценки тяжести порока до операции, варианты в косметической оценке после операции. Уделяется внимание такому направлению, как стандартизация подходов к хирургическому лечению гипоспадии, унификация методов уретропластики и коррекции искривления полового члена. Приводятся данные клинических исследований по использованию различных оперативных техник. Дается представление о стандартизации методов описания клинических исследований в сфере гипоспадологии.

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“…But if the curvature is still significant, the penis can be fully degloved and a dorsal tunica shortening procedure performed. Depending on preference this may be simple Baskin type midline plications, which work well in young children, or alternatively in older patients, a formal mobilisation of the neurovascular bundles and dorsal Yachia modification of the Nesbit procedure may be more reliable (for a detailed description of the technique see [6]).…”

Section: Surgical Stepsmentioning

confidence: 99%