Surgical Approach to Short-Bowel Syndrome

Thompson, Jon S.; Langnas, Alan Norman; Pinch, Lewis W.; Kaufman, Stuart S.; Quigley, Eamonn Martin; Vanderhoof, Jon A.

doi:10.1097/00000658-199522240-00016

Cited by 169 publications

(27 citation statements)

References 22 publications

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“…[1][2][3] Current therapeutic options forcould be more effectively treated if healthy mucosa were available in larger quantities as a replacement or functional supplement. Hence, methods to generate neomucosa, for example, by transplanting intestinal mucosal stem cells, represent a potentially appealing alternative.…”

Section: Introductionmentioning

confidence: 99%

Intestinal Stem Cell Organoid Transplantation Generates Neomucosa in Dogs

Agopian

Chen

Avansino

et al. 2009

Journal of Gastrointestinal Surgery

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Background and Aims Intestinal stem cell organoid transplantation generates functional intestinal neomucosa and has been used therapeutically to improve nutrient absorption and cure bile acid malabsorption in rats. We hypothesized that intestinal organoids can be harvested and transplanted to generate intestinal neomucosa in a large animal model. Materials and Methods In group 1, 2-month old beagles (n=6) underwent autotransplantation of intestinal organoids prepared from a segment of their own ileum. In group 2, intestinal organoids were harvested from fetuses and allotransplanted into 10-month old mother animals (n=4). Tissues were harvested after 4 weeks and analyzed by hematoxylin and eosin histology and fluorescent microscopy. Results Large numbers of viable organoids were harvested in both groups. In group 1, no neomucosal growth was identified in any of the engraftment sites after autotransplantation of juvenile organoids. In group 2, neomucosal growth with large areas of crypts and villi was identified in 11 of 12 polyglycolic acid scaffolds after allotransplantation of fetal organoids. The neomucosa resembled normal canine mucosa in structure and composition. Conclusions Intestinal stem cell organoid transplantation can be used to generate neomucosa in dogs. This is the first report of successful generation of intestinal neomucosa using intestinal stem cell organoid transplantation in a large animal model.

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Section: Introductionmentioning

confidence: 99%

Intestinal Stem Cell Organoid Transplantation Generates Neomucosa in Dogs

Agopian

Chen

Avansino

et al. 2009

Journal of Gastrointestinal Surgery

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“…Erişkinlerde 10-15 cm, çocuklarda 3 cm segment kendi etrafında 180° rotasyonla distal uç ile kolon arasına anastomoze edilir. Erişkinlerde yeterli sonuç alınmıştır, ancak yeterli uzunluk olmazsa işe yaramayabilir (36)(37)(38) .…”

Section: B Anizoperistaltik Ince Bağırsak/izoperistaltik Jejunal Veyunclassified

“…Ayrıca sütürlerin ayrılmasıyla dilatasyon nüksü ve fonksiyonel tıkanıklık olasılığı da vardır. Thompson 11'i çocuk 160 hastada başarıyla uygulamıştır (47) .…”

Section: B Dilate Bağırsakta Motiliteyi Düzeltici Işlemler a İnce unclassified

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Intestinal Failure/Nontransplant surgical interventions for short bowel syndrome

Çelik¹

2017

tcdd

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Öz GirişBağırsak sisteminin bireyin besin alımı ve sıvı dengesini sağlamada yetersiz kaldığı durumlara bağırsak yetmezliği adı verilmektedir. Bağırsak uzunluğunun azaldığı, ileoçekal valvin olmadığı, kolonun kaybedildiği gibi uzunluk kayıpları veya mukozal yetmezlik, dismotilite veya aktif enterit gibi besin emiliminin mümkün olmadığı durumlarda birey kalıcı veya uzun süreli total parenteral beslenmeye mecbur kalabilmektedir (1) . "Büyüme için gerekli sıvı ve besinlerin sindirimi ve emilimi için yeterli miktarda fonksiyonel bağırsak kalmaması" pediatrik bağırsak yetmezliğinin modern tanımlamasıdır. Bir başka tanımda ise, büyüme, hidrasyon ve elektrolit homeostazının bozulmasına neden olan bağırsak hastalığı olarak genellenebilmektedir.

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“…Anti-peristaltic segments. Surgical reconstruction of the residual small bowel using antiperistaltic jejunal segments has been recommended for patients with a resected ileum and ICV [61]. In summary, the technique includes excision of a small segment (10-15cm in length for adults and 3cm for children) of the distal intestine with its mesenteric blood supply rotation over 180 o degree of the distal intestine, and an end-to-end anastomosis between the reversed intestinal segment and the proximal jejunum and distally to the remaining colon [61].…”

Section: Surgical Techniques To Slowing the Intestinal Transitmentioning

confidence: 99%