Surgical and oncological outcome after laparoscopic versus open nephroureterectomy for non-metastatic, upper-tract urothelial carcinoma

Alothman, Khalid I.; Mehmood, Shahbaz; Alzahrani, Hassan M.; Alotaibi, Mohammed; Alkhudair, Waleed K.; Eldali, Abdelmoneim

doi:10.15537/smj.2020.1.24780

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…The risk of bladder cancer after RNU is 35-40% in the literature and is quite high. (5,6) In our study, this rate was 38% in the mean follow-up period of 39.5 months. A higher rate of bladder cancer history was found in the group that developed IVR, and these patients were found to have a higher T-stage and a higher rate of ureteral localization with UTUC.…”

Section: Discussionsupporting

confidence: 45%

“…In the same study, no significant difference was found in IVR. In the literature, findings show that laparoscopic RNU is related to IVR, in addition to studies (5,22) that show no difference in intravesical cancer recurrence between open and laparoscopic RNU (8,23). In addition, the excision of the bladder cuff is important in UTUC surgery.…”

Section: Discussionmentioning

confidence: 99%

“…(4) The risk of bladder cancer after RNU is reported as 35-40% in the literature, which is quite high. (5,6) In 82-89% of the patients, intravesical recurrence (IVR) is observed within 2 years. (6,7) It is important to know the factors predicting metachronous bladder recurrence due to progression, recurrence, and poor prognosis tendency.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for intravesical recurrence after radical nephrourethrectomy in upper urinary tract urothelial tumors: retrospective single-center study

Kargı

Ekşi

2022

New J Urol.

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Objective: We examined factors predicting metachronous recurrence of bladder cancer in our series of patients who underwent radical nephroureterectomy (RNU) for upper system urothelial carcinoma (UTUC). Material and Methods: Patients with UTUC-induced RNU in our center from September 2009 to March 2020 were included in the study. Patients were classified as having and not having an intravesical recurrence (IVR), and the factors predicting recurrence were evaluated. Results: A total of 50 patients were included in the study. IVR was developed in 19 (38%) of 50 patients, with a mean follow-up of 39.5 ± 25.3 months. There was no significant difference between the two groups in demographic characteristics, admission hemoglobin, glomerular filtration rate, and degree of hydronephrosis in preoperative ureterorenoscopy and cytology positivity history (p>0.05). The IVR (+) group had significantly more previous history of bladder cancer (35.5% vs. 52.6%, p=0.019, respectively). While the number of patients with ureteral tumors was 10 (32.3%) in the IVR (-) group, it was 9 (47.4%) in the IVR (+) group, and it was significantly higher. There are 28 (56%) patients with T2-T4 pathology in the entire patient group, and the rate is significantly greater in the IVR (+) group (63.2% vs. 51.6%, p=0.038, respectively). Conclusion: Caution should be exercised for metachronous bladder cancer recurrence in patients with a previous history of bladder cancer, especially in ureteral and high pathological T-stage UTUCs. Keywords: upper urinary tract urothelial carcinoma, intravesical recurrence, risk factor, nephroureterectomy

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

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Risk factors for intravesical recurrence after radical nephrourethrectomy in upper urinary tract urothelial tumors: retrospective single-center study

Kargı

Ekşi

2022

New J Urol.

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“…To the Editor Alothman et al 1 presented their center's experience with UTUC in a well-written interesting article. The authors compared the outcomes of the open and laparoscopic nephroureterectomy techniques in management of UTUC.…”

Section: Comment On: Surgical and Oncological Outcome After Laparoscomentioning

confidence: 99%

Comment on: Surgical and oncological outcome after laparoscopic versus open nephroureterectomy for non-metastatic, upper-tract urothelial carcinoma

Gadelkareem

2020

SMJ

Self Cite

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“…Open radical cystectomy is still the most common used approach of cystectomy in clinical practice. However, the complication of surgical procedure has a high perioperative complication rate and significant mortality [ 1 – 3 ]. In the past decades, the development of laparoscopic instruments and technology became mature, making laparoscopic as a new treatment option for patients with bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcome of laparoscopic versus robot-assisted radical cystectomy for patients with bladder cancer: a retrospective study

Bai

Zheng

et al. 2021

BMC Surg

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Background With the development of minimally invasive surgery technology, patients with bladder cancer are increasingly receiving laparoscopic radical cystectomy (LRC) or robotic-assisted radical cystectomy (RARC) treatment. The main purpose of this study was to compare the long-term outcomes of bladder cancer patients treated with LRC versus RARC. Methods A retrospective study to identify patients with clinical stage Ta/T1/Tis to T3 bladder cancer who underwent RARC or LRC has been performed. The perioperative outcome, recurrence, and overall survival (OS) of the two surgical methods were compared. Results 218 patients were identified from March 2010 to December 2019 in our department, which including 82 (38%) patients who received LRC and 136 (62%) patients who received RARC. There was no significant difference between the two groups in terms of lymph node collection, lymph node positive rate, resection margin positive rate, and postoperative pathological staging. Compared with the LRC group, patients in the RARC group had a median estimated blood loss (180 vs. 250 ml; P = 0.02) and reduced complications at 90 days postoperatively (30.8% vs. 46.3%; P = 0.01). Recurrence, all-cause death, and cancer-specific death occurred in 77 (35%), 55 (25%), and 39 (18%) patients, respectively. The 5-year OS rate was 54.63% and 54.65% in the RARC and LRC group (P > 0.05). The 5-year cancer-specific survival (CSS) rate was 73.32% and 61.55% in RARC and LRC group (P > 0.05). There was no significant difference in OS [hazard ratio (HR) 1.083, 95% confidence interval (CI) 0.626–1.874; P = 0.78], and CSS (HR 0.789, 95%CI 0.411–1.515; P = 0.61) between two groups. Conclusions Both RARC and LRC were safe and effective with a similar long-term clinical outcomes. Moreover, RARC had significantly lower median estimated blood loss and reduced postoperative complications.

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Surgical and oncological outcome after laparoscopic versus open nephroureterectomy for non-metastatic, upper-tract urothelial carcinoma

Cited by 7 publications

References 29 publications

Risk factors for intravesical recurrence after radical nephrourethrectomy in upper urinary tract urothelial tumors: retrospective single-center study

Risk factors for intravesical recurrence after radical nephrourethrectomy in upper urinary tract urothelial tumors: retrospective single-center study

Comment on: Surgical and oncological outcome after laparoscopic versus open nephroureterectomy for non-metastatic, upper-tract urothelial carcinoma

Clinical outcome of laparoscopic versus robot-assisted radical cystectomy for patients with bladder cancer: a retrospective study

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