Surgical and Non-Surgical Management and Treatment of Glioblastoma: I. Primary Tumors

Abstract

Glioblastoma, the most common primary brain tumor in adults, remains an unmet need in oncology. Its management and treatment begin with an understanding of this tumor's morphology, biological types, risk factors, and prognosis. The various surgical and non-surgical modalities devised so far for primary tumors and their metastases are presented and discussed either singly or in combination. For each such therapy, the treatment results obtained in clinical trials and other reported practices are also summarized and discussed. Historically, chemotherapy has provided little durable benefit with tumors recurring within several months, even in the case of more accessible tumors located outside the brain, let alone within the brain behind its protective barriers. More effective therapies involving other options are required either in isolation or more likely in combination. Of these other options, the following are considered here at some length: surgery, conformal radiotherapy, boron neutron therapy, intensity modulated proton beam therapy, antiangiogenic therapy, alternating electric field therapy, immunotherapy without neglecting palliative therapies. A companion paper will discuss the important case of recurring tumors.

Oncogenomics: a personalized cancer therapy

“…The other 5 patients did not stay on the recommended treatment for long enough or did not complete the scans or/and the tests needed for evaluation. [1][2][3][4][5][6][7][8][9][10][11][12][13][14]…”

The role of zinc finger E-box-binding homeoboxin the prognosis of Glioblastoma: A review

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