Surgical and Molecular Pathology of Barrett Esophagus

Zibadi, Sherma; Coppola, Domenico

doi:10.1177/107327481502200208

Cited by 4 publications

(1 citation statement)

References 76 publications

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“…In this study, a low level of DUOX2 mRNA was found in both normal esophagus and columnar epithelium of Barrett esophagus, although a low level of DUOX2 protein was only observed in Barrett esophagus but not normal esophagus. Barrett esophageal mucosa is gastric-type mucosa with intestinal metaphasia induced by the acid-peptic gastric content, which erodes the squamous mucosa [ 26 ]. Barrett esophagus is a well-recognized risk of esophageal adenocarcinoma [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon

Zhou

et al. 2016

Gastroenterology Research and Practice

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Aim. To detect the expression of dual oxidase (DUOX) 2 in Barrett esophagus, gastric cancer, and colorectal cancer (CRC). Materials and Methods. The endoscopic biopsies were collected from patients with Barrett esophagus, while the curative resection tissues were obtained from patients with gastric cancer, CRC, or hepatic carcinoma. The DUOX2 protein and mRNA levels were detected with immunohistochemistry (IHC) and real-time quantitative PCR (qPCR). The correlation of DUOX2 expression with clinicopathological parameters of tumors was identified. Results. Low levels of DUOX2 mRNA were detected in Barrett esophagus and the adjacent normal tissues, and there was no difference between these two groups. DUOX2 protein was found in Barrett esophagus and undetectable in the normal epithelium. The DUOX2 mRNA and protein levels in the gastric cancer and CRC were increased compared to the adjacent nonmalignant tissues. The elevated DUOX2 in the gastric cancer was significantly associated with smoking history. In CRC tissues, the DUOX2 protein expression level in stages II–IV was significantly higher than that in stage I. In both hepatic carcinoma and the adjacent nonmalignant tissue, the DUOX2 was virtually undetectable. Conclusion. DUOX2 in Barrett esophagus, gastric cancer, and CRC may be involved in the tumorigenesis of these tissues.

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Section: Discussionmentioning

confidence: 99%

DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon

Zhou

et al. 2016

Gastroenterology Research and Practice

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Esophagitis and Barrett Esophagus

2018

Diagnostic Pathology: Cytopathology

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Barrett’s esophagus: genetic features

Белова

Руденко

Karmakova

et al. 2020

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The aim of the study was to evaluate the genetic characteristics of the pathological process in patients with biopsy-proven PB. Materials and methods: Dynamic observation and treatment of patients with morphologically confi rmed diagnosis of Barrett’s esophagus (PB) was performed at the Bank of Russia Multidisciplinary medical center in Moscow in the period from 2014 to 2019.the study included 52 patients. Among them, men — 33 (63.4%) and women –19 (36.5%) aged from 28 to 70 years, the peak incidence was mainly in the age range from 50–71 years. As a result, morphological types of PB epithelium were identifi ed at the time of the study: cardiac — 8(15.3%), small — bowel — 25 (48%), large-bowel without dysplasia-17 (32.6%) and large-bowel with mild dysplasia foci –2 (3.8%). The expression of the p53, P63, and Ki-67 genes responsible for cell proliferation and diff erentiation was studied using an immunohistochemical method. Results. As a result of the study, it was found that genetic changes in patients with morphologically confi rmed PB increase from the cardiac type of epithelium in the segment to the detection of dysplasia foci on the background of colonic metaplasia. An exception is tokokishechnaya metaplasia, which may be an indirect sign of the development of highly diff erentiated epithelium in response to gastroesophageal or duodenogastroesophageal refl ux Summary. 1. Mutation of the p 53 genes responsible for regulating cell transcription and activating apoptosis and the P63 gene responsible for cell diff erentiation occurs in all morphological types of PB, with the number of mutations increasing as metastatic changes progress in accordance with the Correa cascade 2. The combination of p53 and P63 gene mutations in almost equal proportions indicates parallel processes of cell proliferation and diff erentiation disorders. 3. Ki-67 expression increases from the cardiac type of epithelium in the segment to the detection of dysplasia foci on the background of metaplastic epithelium. An exception is tokokishechnaya metaplasia, which may be an indirect sign of the development of highly diff erentiated epithelium in response to gastroesophageal or duodenogastroesophageal refl ux. Conclusion. Studies have shown that there are a number of genetic features of the pathological process in patients with morphologically confi rmed PB, the combination of which is more reliable and reliable assessment of the risk of neoplastic changes than individual indicators. To date, it remains relevant to develop a marker panel that is suitable for use in clinical practice, informative for both assessing individual risk and stratifying risk groups, and useful for monitoring the eff ectiveness of treatment.

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Surgical and Molecular Pathology of Barrett Esophagus

Cited by 4 publications

References 76 publications

DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon

DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon

Esophagitis and Barrett Esophagus

Barrett’s esophagus: genetic features

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