Surgical adhesives for laser-assisted wound closure

Abstract

Solid protein solder-doped polymer membranes were developed for laser-assisted tissue repair. Biodegradable polymer membranes of controlled porosity were fabricated with poly(L-lactic-co-glycolic acid) (PLGA), poly(ethylene glycol) (PEG), and salt particles, using a solvent-casting and particulate-leaching technique. The membranes provided a porous scaffold that readily absorbed the traditional protein solder composed of serum albumin, indocyanine green dye, and de-ionized water. In vitro investigations were conducted to assess the influence of various processing parameters on the strength of tissue repairs formed using the new membranes. These parameters included PLGA copolymer and PLGA/PEG blend ratios, membrane pore size, initial albumin weight fraction, and laser irradiance used to denature the solder. Altering the PLGA copolymer ratio had little effect on repair strength, however such variations are known to influence the degradation rate of the membranes. The repair strength increased with increased membrane pore size and bovine serum albumin concentration. The addition of PEG during the membrane casting stage increased the flexibility of the membranes but not necessarily the repair strength. Typically, the repair strength increased with increasing irradiance from 12 to 18 W/cm(2). The new solder-doped polymer membranes provided all of the benefits associated with solid protein solders including high repair strength and improved edge coaptation. In addition, the flexible, moldable nature of the new membranes offers the capability of tailoring the membranes to a wide range of clinically relevant geometries.

Temperature-controlled laser-soldering system and its clinical application for bonding skin incisions

“…Therefore, special dyes (i.e., chromophores), designed to absorb the specific wavelengths of those lasers, were added to the solders so that they would absorb the laser radiation and generate heat. 3,7,8 LTW and LTS have been investigated in many different medical disciplines, including ophthalmology, 9 urology, 10,11 microsurgery, 12 neurosurgery, 13 dermatology, 14 and others. 15 LTS is potentially a method that is easier to use than the existing closure methods, and it is expected that the healing process would be faster and, if performed correctly, will leave minimal scarring.…”

Therapeutic Lasers and Skin Welding Applications

“…Furthermore, due to the increased absorption characteristics of the dyed tissue or solder, low-level laser powers may be used to achieve the required effect, increasing the safety of the technique. The combination of serum albumin and ICG dye with an 800-nm diode laser has been tried in numerous of applications in order to nd optimal solder composition [67][68][69][70][71][72][73]. [74] to investigate the relative importance of these parameters to laser tissue soldering.…”

“…Third, the solid protein solder is not flexible enough to fit different tissue geometries. Specially designed artificial solder-doped PGA membranes were tried for laser tissue soldering by McNally et al and Hodges et al [69,75]. The albumin protein solder and the polymer materials are biodegradable.…”

Study on the formation and properties of red blood cell-like Fe3O4/TbLa3(Bim)12/PLGA composite particles

“…There is an increasing number of multifunctional materials that have been explored, such as magnetic-fluorescent bifunctional materials, 28 electrical-magnetic bifunctional materials, 29 fluorescent-electrical bifunctional materials 30 and electrical-magnetic-fluorescent trifunctional materials. 31 However, the RBC-like multifunctional PLGA composite particles have not been thoroughly studied, especially via the electrospraying technique.…”