Surgery versus surgery and postoperative radiotherapy in squamous cell carcinoma of the buccal mucosa: A comparative study

Abstract

Postoperative radiotherapy was effective in decreasing locoregional failure in patients with close surgical margins, tumor thicker than 10 mm, high-grade tumors, positive node, and bone invasion. The effect of interval between surgery and postoperative radiotherapy on local failure was margin-dependent.

Squamous cell carcinoma of the buccal mucosa: An aggressive cancer requiring multimodality treatment

“…Nair et al 24 from India reported that 109 patients of 238 who received radiotherapy alone had persistent or locoregional recurrent disease. Also from 15 reported on 115 patients treated by surgery alone compared with 61 patients treated by surgery plus postoperative radiotherapy. Actuarial 3-year locoregional control rates for advanced-stage disease in these two groups were 11% and 48%, respectively, in favor of surgery plus postoperative radiotherapy.…”

“…This falls within the 29% to 100% incidence reported in the literature. 15,21,23 A previous report from Taiwan on 57 patients concluded that postoperative radiotherapy was effective in decreasing locoregional failure in patients with close surgical margins, tumor thickness greater than 10 mm, high-grade tumors, and positive node and bone invasion. 13 Of the patients in this study, the S group and S + RT group had similar treatment outcomes in both early and advanced stages despite the fact that 20 of the 58 patients who had S + RT had positive or close surgical margins, whereas no patient in the S group had positive margins.…”

“…In contrast to the high locoregional failure rate, the incidence of systemic dissemination in our patients was 15.7%, a figure higher than the 0.75% to 7% from other studies. 13,15,25 Locoregional failure seems to be the most powerful factor that influences patient survival.…”

“…This conforms to the well-established observation in the literature that postoperative radiotherapy improves survival. 13,15,26 Mishra et al 27 reported on 140 locally advanced buccal cancers. Eighty patients treated with surgery plus postoperative radiotherapy were compared with 60 patients treated with surgery alone.…”

Prognostische Wertigkeit der Zeitparameter in der adjuvanten Radiotherapie von HNO–Tumoren

“…Dixit et al beobachteten eine erhöhte Lokalrezidivrate bei einer postoperativen Wartezeit von > 30 Tagen und knappen Resektionskanten [9]. Nach Parsons et al [23] lag der kritische Grenzwert bei positiven Resektionskanten bei 45 Tagen.…”