Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors

Nuyttens, J.; Rust, Philip F.; Thomas, Charles R.; Turrisi, Andrew T.

doi:10.1002/(sici)1097-0142(20000401)88:7<1517::aid-cncr3>3.0.co;2-9

Cited by 452 publications

(258 citation statements)

References 36 publications

Supporting

Mentioning

223

Contrasting

Unclassified

Order By: Relevance

“…In 2000, a review of the literature was published on the effectiveness of surgery compared with radiation therapy for (non-FAP) patients with desmoid tumours 56. The study showed that radiation therapy alone or in combination with surgery resulted in significantly better control than surgery.…”

Section: Management Of Desmoid Tumoursmentioning

confidence: 99%

Guidelines for the clinical management of familial adenomatous polyposis (FAP)

Vasen

Möslein

Alonso

et al. 2008

Gut

619

525

View full text Add to dashboard Cite

show abstract

Section: Management Of Desmoid Tumoursmentioning

confidence: 99%

Guidelines for the clinical management of familial adenomatous polyposis (FAP)

Vasen

Möslein

Alonso

et al. 2008

Gut

619

525

View full text Add to dashboard Cite

show abstract

“…In contrast to other published series [2,10], a study by Gronchi et al showed that presence of microscopic disease did not affect long-term disease-free survival in patients with primary presentation of extra-abdominal desmoid tumors [11]. Primary RT is an appropriate alternative for patients who are not good surgical candidates [12]. On the other hand the use of postoperative RT is unclear.…”

Section: Discussionmentioning

confidence: 99%

Desmoid tumor of the supraclavicular region: a case report

Koukoutsis

Παππάς

Karanikas

et al. 2009

Cases J

View full text Add to dashboard Cite

Desmoid tumors are rare, benign fibroblastic tumors that are locally infiltrative and can cause extensive morbidity by destruction of adjacent vital structures. Due to the rarity of these tumors, evidence regarding optimal treatment protocols is drawn from case reports and single-arm series with small patient numbers. We report a case of a patient with a desmoid tumor of the left supraclavicular region that was diagnosed and treated in our department and a review of the current literature.

show abstract

“…However, the role of RT for DTs with a positive SM has not been established. Previous studies reported that RT alone (50-60 Gy) or RT combined with surgery in patients with incomplete resection achieved long-term disease control in ~70-80% of DT patients (12,16,17). Spear et al (18) demonstrated that the 5-year local control rate of patients treated with a combination of surgery and RT (n=41) was 72%.…”

Section: Discussionmentioning

confidence: 99%

“…DTs have a high rate of recurrence, even following complete surgical removal, and the contribution of a positive SM to local recurrence rates has not yet been determined. The recurrence rates of patients with resection and a negative SM were reported to be 16-39% (10)(11)(12). In addition, previous studies indicated that the risk of recurrence is independent of the margin status (13,14).…”

Section: Discussionmentioning

confidence: 99%

The clinical effect of a positive surgical margin and adjuvant postoperative radiotherapy in the treatment of resectable desmoid tumors

Karabulut

Keskın

Ekenel

et al. 2013

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Desmoid tumors (DTs) are benign tumors that exhibit fibroblastic proliferation, which arises from fascial or musculoaponeurotic structures. The aim of this study was to investigate the characteristics and outcomes of patients with resectable DTs. A total of 21 patients were included and their clinicopathological characteristics were retrospectively analyzed. The 21 patients (16 females and 5 males) were identified through reviewing the patient charts at our institute. The tumor was located in the lower extremities in 7 cases, in the upper extremities in 4 cases, in the abdominal region in 9 cases and in the neck region in 1 case. Patients who had been initially treated by surgical excision were included in the study. Of these 21 patients, a positive surgical margin (SM) was reported in 11 patients, 7 of whom received postoperative radiotherapy (RT). Ten patients had a negative SM and 6 received RT. A total of 5 patients (46%) in the positive SM group and 4 (40%) in the negative SM group had documented disease relapse (P>0.05). The median relapse-free survival (RFS) was 20.5 months for the patients treated by surgery alone and 50 months for those treated with surgery followed by adjuvant RT (P>0.05). Age, gender, SM and adjuvant RT were not identified as predictors of recurrence. No predictive factors appeared to indicate local DT recurrence following surgery.

show abstract

Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors

Cited by 452 publications

References 36 publications

Guidelines for the clinical management of familial adenomatous polyposis (FAP)

Guidelines for the clinical management of familial adenomatous polyposis (FAP)

Desmoid tumor of the supraclavicular region: a case report

The clinical effect of a positive surgical margin and adjuvant postoperative radiotherapy in the treatment of resectable desmoid tumors

Contact Info

Product

Resources

About