Surgery of vagal paragangliomas: Six patients and review of literature

Lozano, Francisco; Gómez, Juan L.; Mondillo, Maria C.; González‐Porras, José Ramón; González-Sarmiento, Rogelio; Muñoz, Ángel Sánchez-Anguita

doi:10.1016/j.suronc.2008.03.001

Cited by 22 publications

(21 citation statements)

References 33 publications

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“…Lower CN deficits occurred in 5 patients (4 JTPs and 1 VP), all of which regressed except for 2 stable dysphonia (2 JTPs, type DI) and 1 stable XII palsy (large VP). These complication rates are relatively low compared with a reported mean of 2.5 CN/patient affected after VP surgery18 30 45 and with JTP new deficit rates of 39%, 25%, 26%, and 21% for CNs IX, X, XI, and XII, respectively, reported by Jackson et al 46 in the largest surgical series to date.…”

Section: Discussionmentioning

confidence: 66%

“…Preoperative embolization of Shamblin class II or III tumors is often considered as it makes surgery easier, reduces blood loss, and has no effect on CN injury 17 29. VPs not involving the skull base can be operated on, similar to CBPs, but CN X is often sacrificed 17 18 30. VPs extending to the base of the skull and jugular foramen are much more difficult to operate, causing IX, X, and XI CN deficits 31.…”

Section: Introductionmentioning

confidence: 99%

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Arterial embolization with Onyx of head and neck paragangliomas

Michelozzi

Januel

Cuvinciuc

et al. 2015

J NeuroIntervent Surg

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Arterial embolization with Onyx of head and neck paragangliomas

Michelozzi

Januel

Cuvinciuc

et al. 2015

J NeuroIntervent Surg

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“…They account for 0.6 % of all head and neck tumors [1]. In the head and neck, they arise from the carotid body, jugular bulb or vagus nerves.…”

Section: Discussionmentioning

confidence: 99%

“…Vagal PGs are more commonly found in women [4]. Patients with PGs in the head and neck more often present with a neck mass, and most patients are asymptomatic until the tumors are large enough to compress adjacent structures, resulting in cranial nerve deficits and airway compression [1,2,5]. Twenty-four hour urine testing for catecholamines or plasma testing for catecholamines will typically be negative in head and neck tumors given the non-secretory nature of these paragangliomas.…”

Section: Discussionmentioning

confidence: 99%

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Malignant Vagal Paraganglioma

Hamersley

Barrows

Perez

et al. 2015

Head and Neck Pathol

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Paragangliomas are rare, typically benign neuroendocrine tumors that represent a small portion of head and neck tumors. A small percentage of these are known to have malignant potential. They arise from the carotid body, jugular bulb or vagus nerves. There is limited literature discussing the management of malignant vagal paragangliomas. We present a case of a 25 year old female with a left malignant vagal paraganglioma. The following case presentation will describe the presentation, classic radiologic findings, and management of a malignant vagal paraganglioma along with a review of the literature.Keywords Paraganglioma Á Carotid body tumor Á Malignant paraganglioma HistoryA 25 year-old female reported to the emergency department for evaluation of a severe headache. An avid singer, she incidentally complained of difficulty with vocal range and stamina over several months. Family history was negative for head and neck cancer. Physical exam revealed fullness with mild generalized erythema of both the left posterior nasopharynx and the oropharynx. On palpation of the left oropharynx there was no discrete mass, however, the patient endorsed mild tenderness on palpation. Flexible fiberoptic laryngoscopic exam revealed normal bilateral true vocal fold motion and appearance. No cervical lymphadenopathy was appreciated and cranial nerves II-XII were intact. Radiographic FeaturesComputed tomography (CT) identified a 6 9 4 9 3 cm left post-styloid parapharyngeal space avidly enhancing mass (Fig. 1). Magnetic resonance imaging (MRI) confirmed a mass within the left parapharyngeal space that was isointense on T1, slightly hyperintense on T2, and showed multiple flow voids with gadolinium enhancement. The mass was posterior to the carotid bifurcation and anterolateral to the internal jugular vein. Radiographic findings were highly suspicious for a vagal paraganglioma or nerve sheath tumor. Urine catecholamines, vanillylmandelic acid (VMA) panel and thyroid function studies were all within normal limits. Succinyl dehydrogenase (SDH) gene testing was negative.Disclaimer: The opinions and assertions expressed herein are those of the authors and are not to be construed as official or representing the views of the Department of the Navy or the Department of Defense. I certify that all individuals who qualify as authors have been listed; each has participated in the conception and design of this work, the writing of the document, and the approval of the submission of this version; that the document represents valid work; that if we used information derived from another source, we obtained all necessary approvals to use it and made appropriate acknowledgements in the document; and that each takes public responsibility for it. We are military service members.

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