Surgery of tumors of the cerebellum and prefrontal cortex, and sensory memory and motor planning disturbances in children

Castro-Sierra, Eduardo; León, Fernando Chico-Ponce de; Gordillo-Domínguez, Luis Felipe; Raya-Gutiérrez, Rocío

doi:10.1007/s00381-003-0826-x

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…These data confirm and extend two previous reports of impaired auditory short-term memory performance in children with cerebellar tumors [13,41]. Although the first of these reports could not distinguish behavioral performance between patients with midline tumors and those with hemispheric lesions [41], a subsequent study by the same researchers concluded that lesions of the midline portions of the cerebellum do not appear to cause cognitive deficits and that short term memory impairments could be explained by hemispheric damage alone [13]. They observed that three of the patients with midline tumors from their initial study who showed memory deficits had lesions which also affected the adjacent cerebellar hemisphere.…”

Section: Discussionsupporting

confidence: 92%

“…While digit span performance for control subjects was superior when digits were presented aurally relative to visual presentation, patients did not exhibit modality differences. These data confirm and extend two previous reports of impaired auditory short-term memory performance in children with cerebellar tumors [13,41]. Although the first of these reports could not distinguish behavioral performance between patients with midline tumors and those with hemispheric lesions [41], a subsequent study by the same researchers concluded that lesions of the midline portions of the cerebellum do not appear to cause cognitive deficits and that short term memory impairments could be explained by hemispheric damage alone [13].…”

Section: Discussionsupporting

confidence: 89%

“…Recent findings from neuroimaging and patient studies, however, have suggested that the cerebellum also plays a role in higher-order, non-motor processes such as learning, memory and emotion. A growing body of evidence suggests that children can suffer intellectual disabilities after cerebellar tumor resection [9,13,26,32,34,41,43,45,53,54,57,64,65]. Due to the heterogeneity of tumor pathology, tumor location and treatment modalities (e.g., irradiation and chemotherapy) used in these studies, it has been difficult to make inferences as to the role of the cerebellum in specific cognitive processes.…”

Section: Introductionmentioning

confidence: 99%

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Verbal Memory Impairments in Children after Cerebellar Tumor Resection

Kirschen

Davis-Ratner

Milner

et al. 2008

Behavioural Neurology

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This study was designed to investigate cerebellar lobular contributions to specific cognitive deficits observed after cerebellar tumor resection. Verbal working memory (VWM) tasks were administered to children following surgical resection of cerebellar pilocytic astrocytomas and age-matched controls. Anatomical MRI scans were used to quantify the extent of cerebellar lobular damage from each patient's resection. Patients exhibited significantly reduced digit span for auditory but not visual stimuli, relative to controls, and damage to left hemispheral lobule VIII was significantly correlated with this deficit. Patients also showed reduced effects of articulatory suppression and this was correlated with damage to the vermis and hemispheral lobule IV/V bilaterally. Phonological similarity and recency effects did not differ overall between patients and controls, but outlier patients with abnormal phonological similarity effects to either auditory or visual stimuli were found to have damage to hemispheral lobule VIII/VIIB on the left and right, respectively. We postulate that damage to left hemispheral lobule VIII may interfere with encoding of auditory stimuli into the phonological store. These data corroborate neuroimaging studies showing focal cerebellar activation during VWM paradigms, and thereby allow us to predict with greater accuracy which specific neurocognitive processes will be affected by a cerebellar tumor resection.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Verbal Memory Impairments in Children after Cerebellar Tumor Resection

Kirschen

Davis-Ratner

Milner

et al. 2008

Behavioural Neurology

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“…The etiology of CP was not explored in relation to motor planning, despite the fact that its impact on motor function has been established [120][121][122][123][124][125][126][127][128][129][130][131][132]. This is further supported by studies on other pediatric populations which have shown that damage to certain neurological networks is associated with motor planning deficits in children with tumors [133,134] or in children with neurodevelopmental disorders [135,136]. In addition, the results in bilateral tasks cannot be compared to those of unilateral tasks as both types of tasks rely on different neural networks [137,138].…”

Section: Discussionmentioning

confidence: 99%

Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review

et al. 2021

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Individuals with cerebral palsy have difficulties performing activities of daily living. Beyond motor execution impairments, they exhibit motor planning deficits contributing to their difficulties. The objective of this review is to synthesize the behavioral evidence of motor planning deficits during an upper limb motor task in children, adolescents and young adults with cerebral palsy aged between 3 and 21 years. Methods: The inclusion criteria were: (1) including individuals with cerebral palsy from 3 to 21 years old; (2) assessing upper limb motor planning. Six databases were screened. The quality assessment of the studies was performed. Results: Forty-six studies and 686 participants were included. Five articles have been identified as very high quality, 12 as high, 20 as moderate, six as low, three as very low. Force planning studies reported a deficit for the more affected hand but adequate performances for the less affected hand. Object-manipulation studies reported hand posture planning deficits irrespectively of the hand assessed. Conclusions: Motor planning deficits has been shown in the more affected hand for force scaling, while the results for other variables showed overall deficits. Hence, variables affected by motor planning deficits in both hands should be considered in children with cerebral palsy to optimize intervention.

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“…42 A general impairment of working memory accompanied by visual memory and/or auditory memory impairment with no functional predominance has been observed in children undergoing operations for cerebellar tumors. 12 Cognitive deficits following treatment for pediatric cerebellar tumors have been shown to affect visual working memory in particular. 38 In children treated for a malignant posterior fossa tumor, Puget et al 64 showed that damage to the dentate nuclei and the inferior vermis could predict the degree of impairment of neurological and neuropsychological functions in these children.…”

Section: Memory Disordersmentioning

confidence: 99%

Cognitive disorders in pediatric medulloblastoma: what neuroimaging has to offer

Hoang

Pagnier

Guichardet

et al. 2014

PED

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Medulloblastomas are the most common malignant childhood brain tumors arising in the posterior fossa. Treatment improvements for these tumors have meant that there are a greater number of survivors, but this long-term patient survival has increased the awareness of resulting neurocognitive deficits. Impairments in attention, memory, executive functions, and intelligence quotient demonstrate that the cerebellum likely plays a significant role in numerous higher cognitive functions such as language, cognitive, and emotional functions. In addition, children with medulloblastoma not only have cerebellar lesions but also brain white matter damages due to radiation and chemotherapy. Functional neuroimaging, a noninvasive method with many advantages, has become the standard tool in clinical and cognitive neuroscience research. By reviewing functional neuroimaging studies, this review aims to clarify the role of the cerebellum in cognitive function and explain more clearly cognitive sequelae due to polytherapy in children with medulloblastoma. This review suggests that the posterior cerebellar lobes are crucial to maintaining cognitive performance. Clinical investigations could help to better assess the involvement of these lobes in cognitive functions.

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Surgery of tumors of the cerebellum and prefrontal cortex, and sensory memory and motor planning disturbances in children

Cited by 6 publications

References 20 publications

Verbal Memory Impairments in Children after Cerebellar Tumor Resection

Verbal Memory Impairments in Children after Cerebellar Tumor Resection

Upper Limb Motor Planning in Individuals with Cerebral Palsy Aged between 3 and 21 Years Old: A Systematic Review

Cognitive disorders in pediatric medulloblastoma: what neuroimaging has to offer

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