Surgery of the Spleen

Scott‐Conner, Carol E. H.; Mancino, Anne T.; Lawrence, John

doi:10.1007/978-1-59259-124-4_17

Cited by 2 publications

(7 citation statements)

References 264 publications

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“…Patients with hematological neoplasia become less well after splenectomy than those with autoimmune hemolytic disorders (9) . According to the current study, patients with hematologic neoplasia had a 7.17-fold greater mortality.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies reported pulmonary complications as the most common complications after splenectomy, occurring in nearly 30% of cases (7)(8)(9) . Furthermore, a study concluded that pneumonia was the only independent factor for mortality in patients, who had undergone splenectomy for non-traumatic spleen disease (8) .…”

Section: Discussionmentioning

confidence: 99%

“…Postoperative bleeding occurs mostly when splenectomy is performed for hypersplenism, particularly in patients with thrombocytopenia (9) . In the current study, postoperative bleeding developed in 6.1% of the cases.…”

Section: Discussionmentioning

confidence: 99%

“…Gastric injury and leakage are rare and preventable complications of splenic surgery (9) . In the current study, it occurred in two of the deceased patients leading to intraabdominal abscess in one, who had undergone the Shugiura procedure.…”

Section: Discussionmentioning

confidence: 99%

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The Predictors of Mortality in Non-Traumatic Splenectomies

Şimşek

2020

Arq. Gastroenterol.

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BACKGROUND: There are quite a few studies examining prognostic factors in non-traumatic splenectomies compared to traumatic ones. OBJECTIVE: This study aimed to evaluate the predictors of mortality in patients who underwent splenectomy for non-traumatic spleen diseases. METHODS: Medical records of the patients, who had undergone total splenectomy for non-traumatic spleen diseases at a tertiary center between January 2009 and December 2019, were retrospectively reviewed. Exclusion criteria included patients younger than 18 years of age, partial splenectomies, splenectomies applied to facilitate surgery for malignancy on contiguous organs, and splenectomies performed during liver transplantation. Iatrogenic splenic injuries were regarded as trauma and these cases were also excluded. RESULTS: The current study included 98 patients. Nine (9.2%) patients died. In univariate analysis, age, the presence of hematological neoplasia, hematocrit, hemoglobin, white blood cell counts, neutrophil-to-lymphocyte ratio, indications for splenectomy, application of emergency surgery, surgical technique, and transfusion of blood components were all significantly associated with mortality. In multivariate analysis, the presence of hematological malignancy [P=0.072; OR=7.17; (CI: 0.386-61.56)], the application of emergency surgery [P=0.035; OR=8.33; (CI: 1.165-59.595)] and leukocytosis [P=0.057; OR=1.136; (CI: 0.996-1.296)] were found to be positively associated with mortality. CONCLUSION: Hematologic neoplasia, emergency surgery, and leukocytosis were the independent predictors of mortality in patients, who were operated on for non-traumatic spleen diseases. A thorough preoperative evaluation, early therapeutic intervention, and advanced surgical techniques are important and can serve to minimize complications and mortality in case of inevitable splenectomy. Immunological research can provide new therapeutic opportunities that may impact positively on patients by minimizing morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Predictors of Mortality in Non-Traumatic Splenectomies

Şimşek

2020

Arq. Gastroenterol.

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“…Outras complicações mais graves são hemorragia pós-operatória, abscesso subfrênico, pancreatite, pneumonia, infecções da ferida operatória, sepse, embolia pulmonar e trombose no sistema porta. 3,8,21 No presente trabalho, nenhuma dessas adversidades foi encontrada.…”

Section: Discussionunclassified

Análise de sobrevivência relacionada ao sexo, após esplenectomia, em modelo animal

Alberti¹,

Rocha

Caldeira³

et al. 2007

Rev. Bras. Hematol. Hemoter.

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É sabido que a esplenectomia causa propensão a infecções, principalmente aquelas causadas por microorganismos capsulados. Essas complicações acompanham-se de maior mortalidade e conseqüente menor sobrevida dos indivíduos asplênicos. O objetivo do presente trabalho foi avaliar a sobrevida em relação ao sexo de ratos submetidos a esplenectomia total. Foram estudados 34 ratos, distribuídos em dois grupos, sendo o Grupo 1 (n=14) controle, animais submetidos apenas a laparotomia e o Grupo 2 (n=20) submetidos a esplenectomia total. Os animais de cada grupo foram distribuídos em dois subgrupos iguais, sendo o Subgrupo A composto por machos e o Subgrupo B por fêmeas. Os ratos foram acompanhados por um período máximo de noventa dias com vista à sua sobrevivência. Observou-se que a mortalidade após esplenectomia total foi de 80% no Subgrupo dos animais machos e de 30% no das fêmeas. Não houve óbitos no Grupo 1. Os ratos esplenectomizados apresentaram sobrevida inferior à das ratas esplenectomizadas (p = 0,034). De acordo com os resultados obtidos, a esplenectomia diminui a sobrevida de ratos, e as fêmeas murinas apresentam maior resistência à asplenia e conseqüentemente menor mortalidade do que os machos. Rev. bras.

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Surgery of the Spleen

Cited by 2 publications

References 264 publications

The Predictors of Mortality in Non-Traumatic Splenectomies

The Predictors of Mortality in Non-Traumatic Splenectomies

Análise de sobrevivência relacionada ao sexo, após esplenectomia, em modelo animal

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