Surgery of Glomus Jugulare Tumors

Pareschi, Roberto; Colombo, Stefano; Mincione, A

doi:10.1055/s-2007-984239

Cited by 11 publications

(17 citation statements)

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“…In published surgical series, 1,9,18,36,37,53,54,57,58,67,68 the results of total resection vary between 76% and 96%. Reported recurrence rates are between 7% and 10% with a median time to recurrence of 5.8 years in one study.…”

Section: Fig 2 Tumor Progression-free Survival After Gkrsmentioning

confidence: 99%

Gamma Knife radiosurgery for glomus jugulare tumors: a single-center series of 75 cases

Ibrahim

Ammori

Yianni

et al. 2017

Journal of Neurosurgery

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OBJECTIVE Glomus jugulare tumors are rare indolent tumors that frequently involve the lower cranial nerves (CNs). Complete resection can be difficult and associated with lower CN injury. Gamma Knife radiosurgery (GKRS) has established its role as a noninvasive alternative treatment option for these often formidable lesions. The authors aimed to review their experience at the National Centre for Stereotactic Radiosurgery, Sheffield, United Kingdom, specifically the long-term tumor control rate and complications of GKRS for these lesions. METHODS Clinical and radiological data were retrospectively reviewed for patients treated between March 1994 and December 2010. Data were available for 75 patients harboring 76 tumors. The tumors in 3 patients were treated in 2 stages. Familial and/or hereditary history was noted in 12 patients, 2 of whom had catecholamine-secreting and/or active tumors. Gamma Knife radiosurgery was the primary treatment modality in 47 patients (63%). The median age at the time of treatment was 55 years. The median tumor volume was 7 cm, and the median radiosurgical dose to the tumor margin was 18 Gy (range 12-25 Gy). The median duration of radiological follow-up was 51.5 months (range 12-230 months), and the median clinical follow-up was 38.5 months (range 6-223 months). RESULTS The overall tumor control rate was 93.4% with low CN morbidity. Improvement of preexisting deficits was noted in 15 patients (20%). A stationary clinical course and no progression of symptoms were noted in 48 patients (64%). Twelve patients (16%) had new symptoms or progression of their preexisting symptoms. The Kaplan-Meier actuarial tumor control rate was 92.2% at 5 years and 86.3% at 10 years. CONCLUSIONS Gamma Knife radiosurgery offers a risk-versus-benefit treatment option with very low CN morbidity and stable long-term results.

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Section: Fig 2 Tumor Progression-free Survival After Gkrsmentioning

confidence: 99%

Gamma Knife radiosurgery for glomus jugulare tumors: a single-center series of 75 cases

Ibrahim

Ammori

Yianni

et al. 2017

Journal of Neurosurgery

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“…Our search resulted in 46 publications describing outcomes for 869 patients treated for glomus jugulare tu mors. 1,3,5,[7][8][9][11][12][13][14][19][20][21][22][25][26][27]29,30,[32][33][34][35][36][37][38][39][40][41][42][43][44]47,48,[50][51][52][53][54][56][57][58][61][62][63][64] We then excluded articles that combined patient outcomes of glomus jugulare tumors with other histologically different jugular foramen tumors unless there was a clear distinction between the outcomes of the patients who had glomus jugulare tumors or if the articles were not available in the English-language literature. We then excluded individual patients based on the following criteria: those with a nonjugular foramen tumor location, those with inadequate data presentation, and those who received...…”

Section: Article Selectionmentioning

confidence: 99%

A meta-analysis of tumor control rates and treatment-related morbidity for patients with glomus jugulare tumors

Ivan

Sughrue²,

Clark³

et al. 2011

JNS

119

111

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The authors' analysis is limited by the quality and accuracy of these studies and may reflect source study biases, as it is impossible to control for the quality of the data reported in the literature. Finally, due to the diverse range of data presentation, the authors found that they were limited in their ability to study and control for certain variables. Some of these limitations should be minimized with their use of meta-analysis methods, which statistically evaluate and adjust for between-study heterogeneity. These results provide the impetus to initiate a prospective study, appropriately controlling for variables that can confound the retrospective analyses that largely comprise the existing literature.

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“…When the percentage of subtotal resections is considered, some reports have to be excluded from any comparison. Although Jackson and coworkers 8 and Pareschi and others 12 reported 10% and 16% subtotal resection rates in patients with intracranial tumors, respectively, they did not specify the incidence of extra-and intradural lesions. Tran Ba Hui et al 15 classified the jugular paragangliomas that they treated surgically using the Fisch classification and reported that 30% were subtotal resections.…”

Section: Discussionmentioning

confidence: 98%

“…The limited rate of recurrence is probably related to anterior transposition of the facial nerve which is a fundamental surgical step in the infratemporal approach. 2,3,8,12,13,15 Tran Ba Hui et al 15 contest this, as according to their data not mobilizing the facial nerve did not compromise the efficacy of tumor removal.…”

Section: Discussionmentioning

confidence: 98%

“…for tumor resection from the intratemporal (internal carotid) or intradural (vertebral/basilar) artery systems, the treatment of recurrences, and the role of radiotherapy. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] The few papers on this topic are sometimes difficult to compare because of different strategies adopted and different methods of reporting the results.…”

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