Surgery-mediated tumor-promoting effects on the immune microenvironment

Cheng, Xiang; Zhang, Hongji; Hamad, Ahmad; Huang, Hai; Tsung, Allan

doi:10.1016/j.semcancer.2022.01.006

Cited by 40 publications

(26 citation statements)

References 249 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the surgical point of view, it is possible that the wound healing promoting properties of BC—as well as the wound healing factors secreted by the wound—exert adverse effects on immune cell activation, especially cells that play a central role within the TH1-immune axis. Although accelerated wound healing promotes quick recovery of the surgical wound, it might also suppress anti-tumor immunity [ 41 , 42 , 43 , 44 ]. In the study of Park et al [ 39 ], the authors also designed various anti-cancer therapies based on implantable scaffolds.…”

Section: Discussionmentioning

confidence: 99%

Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies

et al. 2022

View full text Add to dashboard Cite

Immune checkpoint blocking therapy is a promising cancer treatment modality, though it has limitations such as systemic toxicity, which can often be traced to uncontrolled antibody spread. Controlling antibody release with delivery systems is, therefore, an attractive approach to reduce systemic antibody spread and potentially mitigate the side effects of checkpoint immunotherapy. Here, bacterial cellulose (BC) was produced and investigated as a delivery system for optimizing checkpoint-blocking antibody delivery. BC was produced in 24-well plates, and afterward, the edges were removed to obtain square-shaped BC samples with a surface of ~49 mm2. This customization was necessary to allow smooth in vivo implantation. Scanning electron microscopy revealed the dense cellulose network within BC. Human IgG antibody was included as the model antibody for loading and release studies. IgG antibody solution was injected into the center of BC samples. In vitro, all IgG was released within 24 to 48 h. Cell culture experiments demonstrated that BC neither exerted cytotoxic effects nor induced dendritic cell activation. Antibody binding assays demonstrated that BC does not hamper antibody function. Finally, antibody-loaded BC was implanted in mice, and serum measurements revealed that BC significantly reduced IgG and anti-CTLA-4 spread in mice. BC implantation did not induce side effects in mice. Altogether, BC is a promising and safe delivery system for optimizing the delivery and release of checkpoint-blocking antibodies.

show abstract

Section: Discussionmentioning

confidence: 99%

Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Activated platelets can recruit neutrophils by releasing chemical mediators such as CXCL4 ( 122 ) and directly interact with integrin αMβ2 on neutrophils via GPIb or integrin αIIβ3 to activate and regulate the functions of neutrophils ( 123 , 124 ). After activation by various stimuli (e.g., infection, surgery, activated platelets), neutrophils can release reticular ultrastructures composed of protein-studded chromatin called NETs ( 52 , 125 , 126 ). NETs play a double-edged role.…”

Section: Activated Platelets Provide Favorable Environment For Pc Cellsmentioning

confidence: 99%

Challenges and Opportunities Associated With Platelets in Pancreatic Cancer

et al. 2022

View full text Add to dashboard Cite

Pancreatic cancer is one of the most common malignant tumors in the digestive system with a poor prognosis. Accordingly, better understanding of the molecular mechanisms and innovative therapies are warranted to improve the prognosis of this patient population. In addition to playing a crucial role in coagulation, platelets reportedly contribute to the growth, invasion and metastasis of various tumors, including pancreatic cancer. This narrative review brings together currently available evidence on the impact of platelets on pancreatic cancer, including the platelet-related molecular mechanisms of cancer promotion, pancreatic cancer fibrosis, immune evasion, drug resistance mechanisms, thrombosis, targeted platelet therapy, combined radiotherapy and chemotherapy treatment, platelet combined with nanotechnology treatment and potential applications of pancreatic cancer organoids. A refined understanding of the role of platelets in pancreatic cancer provides the foothold for identifying new therapeutic targets.

show abstract

“…In addition to changed neutrophils function themselves, influence NETs is also an effective tumor therapy method. Studies have shown that NETs can promote metastasize of circulating tumor cells. , Chen and colleagues developed a method to release DNase I, a protein that has been shown the function of NETs degradation, by light-regulated for cancer therapy …”

Section: Nanotechnology Combined With Neutrophil Function For Disease...mentioning

confidence: 99%

Usage of Nanoparticles to Alter Neutrophils’ Function for Therapy

Wang

Yan

et al. 2022

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Neutrophils, the most abundant white blood cells in the human body, are important immune cells responsible for the innate immune response. Neutrophils can migrate to inflammatory areas, such as tumor sites and infection sites, because of chemotaxis. Neutrophil-based nanomaterials, such as neutrophil-nanomaterial composites and neutrophil membranebased nanomaterials, can help the drug or imaging agent gather in the inflammatory area with the help of chemotaxis. In addition, some nanomaterials can interfere with the function of neutrophils to treat tissue damage caused by excessive local accumulation of neutrophils. This review focuses on the interaction between nanomaterials and neutrophils as well as the applications of neutrophil-based nanomaterials and neutrophilinterfering nanomaterials.

show abstract

Surgery-mediated tumor-promoting effects on the immune microenvironment

Cited by 40 publications

References 249 publications

Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies

Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies

Challenges and Opportunities Associated With Platelets in Pancreatic Cancer

Usage of Nanoparticles to Alter Neutrophils’ Function for Therapy

Contact Info

Product

Resources

About