Surgery for Pancreatic Neuroendocrine Tumor G3 and Carcinoma G3 Should be Considered Separately

Surgery of the primary tumour in 201 patients with high‐grade gastroenteropancreatic neuroendocrine and mixed neuroendocrine‐non‐neuroendocrine neoplasms

“…Resection of the primary tumour was an independent prognostic factor for improved survival, regardless of stage. In another study of 67 patients with pancreatic NET G3 (n = 21) and NEC (n = 46), survival was improved after resection of NET G3, regardless of the presence of metastases 23 . However, in patients with NEC, survival was not significantly improved after surgical treatment, independent of metastases.…”

“…(n = 21) and NEC (n = 46), survival was improved after resection of NET G3, regardless of the presence of metastases. 23 However, in patients with NEC, survival was not significantly improved after surgical treatment, independent of metastases. In the present study, we did not find any effect of the primary tumour location, 28 In the present study, we found no difference in prognosis between oesophageal NEC and MiNEN.…”

Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

“…The role of surgery for localised Pan-NEC G3 is still controversial, as upfront surgery may not have a clear benefit in terms of survival. 37 For Pan-NETs in patients affected by MEN1 syndrome, see Section 1 of supplementary Material, available at Annals of Oncology online.…”

Update on gastroenteropancreatic neuroendocrine tumors

“…The role of surgery for GEP-NENs G3 is still debated. According to some retrospective series, radical surgical resection is associated with a survival benefit as compared to systemic therapies or palliative resection alone in patients with localized GEP-NENs G3 [118][119][120][121] , especially when well-differentiated [120 , 121] . Furthermore, a possible survival benefit has been recently reported also for highly selected patients with metastatic well-differentiated PanNETs G3 submitted to radical surgery [121 , 122] .…”