Surgery for Obesity and Weight-Related Diseases Changes the Inflammatory Profile in Women with Severe Obesity: a Randomized Controlled Clinical Trial

Sousa, Alan Robson Trigueiro de; Freitas, Wilson Rodrigues de; Perez, Eduardo Araújo; Ilias, Elias Jirjoss; Silva, Anderson Soares; Alves, Vera Lúcia dos Santos; Afonso, João Pedro Ribeiro; Oliveira, Miriã Cândida; Fonseca, Adriano Luís; Silva, Marcos Mota da; Lino, Maria Eduarda Moreira; Oliveira, Manoel Carneiro; Pedro, Wilson José Sena; Bachi, André Luís Lacerda; Insalaco, Giuseppe; Malheiros, Carlos Alberto; Oliveira, Luís Vicente Franco de

doi:10.1007/s11695-021-05702-5

Cited by 3 publications

(5 citation statements)

References 71 publications

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“…To confirm that RYGB surgery has a remarkable ability to modulate the Th17 profile, we also evaluated the serum levels of IL-23, which is a promoter molecule in the Th17 profile [ 67 ]. Serum levels of IL-23 significantly reduced after surgery, which corroborates with other studies that found a decrease in IL-23 levels after bariatric surgery in patients with insulin resistance, particularly in the context of RYGB surgery [ 64 , 67 , 68 ]. We also found a positive correlation between the serum levels of IL-17 and IL-23 both before and after surgery in the BSG group, which reiterates the reports in literature regarding the production and concomitant action of these molecules.…”

Section: Discussionsupporting

confidence: 89%

“…Bariatric surgery is currently the most widely used therapeutic option for severe MS and among MS patients, the Roux-en-Y gastric bypass (RYGB) procedure is particularly important; a surgical procedure that is characterized by a restriction and lower absorption, owing to a small gastric pouch and a total bypass of the duodenum and proximal jejunum [ 10 – 12 ]. It is worth noting that reducing body weight using bariatric surgery is effective in decreasing the severity of chronic inflammation, and therefore, the development of comorbidities associated with obesity [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Roux-en-Y gastric bypass on the metabolic profile and systemic inflammatory status of women with metabolic syndrome: randomized controlled clinical trial

Felipe

Bachi

Oliveira

et al. 2023

Diabetol Metab Syndr

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Background Obesity remains a public health problem worldwide. The high prevalence of this condition in the population raises further concerns, considering that comorbidities are often associated with obesity. Among the comorbidities closely associated with obesity, metabolic syndrome (MS) is particularly important, which potentially increases the risk of manifestation of other disorders, such as the prothrombotic and systemic pro-inflammatory states. Methods A randomized, controlled clinical trial was performed involving female patients (n = 32) aged between 18 and 65 years, with a clinical diagnosis of MS, with severe obesity undergoing Roux-en-Y gastric bypass (RYGB). The study design followed the Consolidated Standards of Reporting Trials statement (CONSORT). Lipid profile, blood glucose and adipokines (adiponectin, leptin, and resistin) and (cytokines IL-1β, IL-6, IL-17, IL-23, and TNF-α) in blood plasma samples were evaluated before and six months after RYGB. Results Patients undergoing RYGB (BSG) showed a significant improvement from preoperative grade III obesity to postoperative grade I obesity. The results showed that while HDL levels increased, the other parameters showed a significant reduction in their postoperative values when compared not only to the values observed before surgery in the BSG group, but also to the values obtained in the control group (CG). As for systemic inflammatory markers adiponectin, leptin, resistin, IL-1β, IL-6, IL-17, IL-23 and TNF- α it was observed that the levels of resistin and IL-17 in the second evaluation increased significantly when compared to the levels observed in the first evaluation in the CG. In the BSG group, while the levels of adiponectin increased, the levels of the other markers showed significant reductions in the postoperative period, in relation to the respective preoperative levels. The analysis of Spearman’s correlation coefficient showed a significant positive correlation between IL-17 and IL-23 in the preoperative period, significant positive correlations between TNF-α and IL-6, TNF-α and IL-17, IL-6 and IL-17, and IL-17 and IL-23 were observed postoperatively. Conclusions According to our results, the reduction of anthropometric measurements induced by RYGB, significantly improves not only the plasma biochemical parameters (lipid profile and glycemia), but also the systemic inflammatory status of severely obese patients with MS. Trials registration NCT02409160

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effects of Roux-en-Y gastric bypass on the metabolic profile and systemic inflammatory status of women with metabolic syndrome: randomized controlled clinical trial

Felipe

Bachi

Oliveira

et al. 2023

Diabetol Metab Syndr

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“…Seventy-two percent (26/36) of patients at 3 months achieved an excess weight loss (EBWL) ≥ 25% and 47% (17/36) succeeded ≥ 45% EBWL at 6 months ( Table 1 ). As bariatric surgery has shown an important impact on different inflammatory markers, 4 , 5 , 6 we also determined if bariatric surgery affected the accumulation of LDN in circulation as an indicator of improvement of inflammation. For this, we tested the effect of bariatric surgery on LDN in the peripheral blood of MOP in a prospective longitudinal study.…”

Section: Resultsmentioning

confidence: 99%

“…Bariatric surgery, an intervention initially intended for weight loss, is known to improve metabolic dysfunction and lower the risk for the development of obesity-related cancers. 3 Also, recent studies have shown that bariatric surgery significantly reduces several inflammatory mediators such as cytokines, hormones, and acute phase reactants, 4 , 5 most likely as a result of the resolution of metabolic disturbances. 6 However, much less is known about inflammatory cells.…”

Section: Introductionmentioning

confidence: 99%

Increased inflammatory low-density neutrophils in severe obesity and effect of bariatric surgery: Results from case-control and prospective cohort studies

et al. 2022

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“…Blood levels of IL-23 and IL-17 are elevated in obese women, IL-23 is decreased after bariatric surgery 9 , and Th17 cells are also decreased by weight loss in pediatric obesity 10 . These sutdies show the role of the IL-23-Th17 pathway in adipose tissue, and the potential attenuation of Th17-mediated inflammation by weight loss.…”

Section: Discussionmentioning

confidence: 99%

Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events

Maezawa

Endo

Kono

et al. 2023

J of Diabetes Invest

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Psoriasis is a chronic inflammatory skin disease that is associated with obesity and myocardial infarction. Obesity‐induced changes in lipid metabolism promote T helper 17 (Th17) cell differentiation, which in turn promotes chronic inflammation. Th17 cells have central roles in many inflammatory diseases, including psoriasis and atherosclerosis; however, whether treatment of obesity attenuates Th17 cells and chronic inflammatory diseases has been unknown. In this study, we found an increase in Th17 cells in a patient with obesity, type 2 diabetes and psoriasis. Furthermore, weight loss with diet and exercise resulted in a decrease in Th17 cells and improvement of psoriasis. This case supports the hypothesis that obesity leads to an increase in Th17 cells and chronic inflammation of the skin and blood vessel walls, thereby promoting psoriasis and atherosclerosis.

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Surgery for Obesity and Weight-Related Diseases Changes the Inflammatory Profile in Women with Severe Obesity: a Randomized Controlled Clinical Trial

Cited by 3 publications

References 71 publications

Effects of Roux-en-Y gastric bypass on the metabolic profile and systemic inflammatory status of women with metabolic syndrome: randomized controlled clinical trial

Effects of Roux-en-Y gastric bypass on the metabolic profile and systemic inflammatory status of women with metabolic syndrome: randomized controlled clinical trial

Increased inflammatory low-density neutrophils in severe obesity and effect of bariatric surgery: Results from case-control and prospective cohort studies

Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events

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