Surgery at Waterloo

Crumplin, M. K. H.

doi:10.1177/014107688808100117

Cited by 6 publications

(11 citation statements)

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“…CFX is a synthetic fluoroquinolone antimicrobial agent whose primary mechanism of action against microorganisms involves inhibition of topoisomerase IV and DNA gyrase. [17] CFX is active against both Gram-positive and Gram-negative bacteria. We have analyzed the delivery kinetics of CFX entrapped in two PVA scaffolds with extreme morphologies by UV-vis spectrometry.…”

Section: Introductionmentioning

confidence: 99%

Poly(vinyl alcohol) Scaffolds with Tailored Morphologies for Drug Delivery and Controlled Release

Gutiérrez

García-Carvajal

Jobbágy

et al. 2007

Adv Funct Materials

201

157

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Poly(vinyl alcohol) (PVA) scaffolds are prepared by a cryogenic process that consists of the unidirectional freezing of a PVA solution. The scaffolds exhibit a microchanneled structure, the morphology of which (in terms of pore diameter, surface area, and thickness of matter accumulated between adjacent microchannels) can be finely tailored by the averaged molecular weight of PVA, the PVA concentration in the solution, and the freezing rate of the PVA solution. The resulting PVA scaffolds are suitable substrates for drug‐delivery purposes, the drug release being controlled (from tens of minutes up to several days) by the morphology of the microchanneled structure. In vitro experiments reveal the efficiency of PVA scaffolds for controlling the release of ciprofloxacin into a bacteria culture medium.

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Section: Introductionmentioning

confidence: 99%

Poly(vinyl alcohol) Scaffolds with Tailored Morphologies for Drug Delivery and Controlled Release

Gutiérrez

García-Carvajal

Jobbágy

et al. 2007

Adv Funct Materials

201

157

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“…Credit must be given to Professor S. Brugmans, inspector general of the Low Countries Medical Department, who along with redoubtable surgeons such as Medical Officer 1st Class J Kluyskens and many other Dutch/Belgian colleagues gave significant support to the Allied Army and its medical staff (ref 2, page 12).…”

Section: The Medical Staffmentioning

confidence: 99%

“…Of the two ADG army corps, we know that the 1st Corps dressing station was in the farm and environs of Mont St Jean Farm, 500 m or so behind Wellington's line (ref 2, page 12); the whereabouts of the 2nd Corps station remains obscure. Two experienced corps PMOs had been appointed: Deputy Inspector John Gunning, (1st Corps), based at Mont St Jean Farm, where there is now a plaque dedicated to him and his staff, placed there by the Royal Army Medical Corps, and Staff Surgeon Henry Gresley Emery (2nd Corps) who had served in many difficult campaigns (Corunna, Walcheren and Burgos).…”

Section: The Medical Staffmentioning

confidence: 99%

“…The provision of hospital staff was to prove inadequate, with 62 other staff and several civilians coming out to help, after the battle. Significantly, of the medical men at Waterloo, only 49% had seen Peninsular service (63% of the non-regimental staff and 45% of battalion surgeons) (ref 2, page 9).…”

Section: The Medical Staffmentioning

confidence: 99%

“…the French) on Sunday 18 June. Around 40 000 casualties of both armies evolved from Waterloo and Quatre Bras (ref 2, page 28); added to these would be around 20 000 from the other two actions, at Ligny and Wavre, so much would be required of the surgeons over the 15–18 June.…”

Section: Introductionmentioning

confidence: 99%

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Medical aspects of the Battle of Waterloo: the battle

Crumplin¹

2014

J R Army Med Corps

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The Duke of Wellington's polyglot army assembled for the Waterloo campaign was hastily aggregated and the Army Medical Department was somewhat short of staff and not entirely of the calibre of the department serving latterly in the Peninsular campaigns. The casualty rates during the battles of this campaign were high and the regimental and hospital staff struggled with the large number of casualties. Lack of stretcher bearers and transport were significant problems, which were compounded by the high density of the casualties. Three quarters of the surviving wounded rejoined their units.

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Correlation between umuC induction and Salmonella mutagenicity assay for quinolone antimicrobial agents

Power¹

1993

FEMS Microbiology Letters

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Quinolone antimicrobial agents induce the SOS response in bacteria, including the umuDC genes necessary for error-prone repair. Consequently these drugs may be mutagenic in bacteria with a functional SOS response. Differential killing tests with Escherichia coli WP2 (trp) and its repair-deficient derivative CM871 (trp lexA recA uvrA) indicated that a functional DNA repair system was protective against the action of quinolones, implying that quinolones are causing some form of DNA damage (not necessarily directly) and are therefore genotoxic. Dose-dependent reversion from His- to His+ with quinolones was observed in the Ames test with Salmonella typhimurium TA102 (uvr+) but in no other Salmonella tester strains (all uvr-), suggesting that a functional excision repair system is essential for quinolone-induced bacterial mutagenesis. A significant correlation between SOS inducing potential (SOSIP) and mutagenic potential in the Ames test (r = 0.89) indicated that quinolone-induced mutagenic effects in bacteria are almost entirely due to SOS-processed DNA damage.

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Surgery at Waterloo

Cited by 6 publications

References 0 publications

Poly(vinyl alcohol) Scaffolds with Tailored Morphologies for Drug Delivery and Controlled Release

Poly(vinyl alcohol) Scaffolds with Tailored Morphologies for Drug Delivery and Controlled Release

Medical aspects of the Battle of Waterloo: the battle

Correlation between umuC induction and Salmonella mutagenicity assay for quinolone antimicrobial agents

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