Surgery associated with increased survival compared to radiation in clinically localized Gleason 9–10 prostate cancer: a SEER analysis

Nemirovsky, Amy; Huang, Hubert; Kibria, Gulam Muhammed Al; Naslund, Michael J.; Siddiqui, Mohummad Minhaj

doi:10.1007/s00345-020-03215-x

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…First, the present data validated previously established differences between EBRT and RP patients regarding age, stage and grade 15,16 . In consequence, the SEER database is consistent with other large‐ and small‐scaled databases, in that regard.…”

Section: Discussionsupporting

confidence: 89%

External beam radiotherapy and radical prostatectomy are associated with better survival in Asian prostate cancer patients

et al. 2021

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Objectives: To test the effect of race/ethnicity on cancer-specific mortality after radical prostatectomy or external beam radiotherapy in localized prostate cancer patients. Methods: In the Surveillance, Epidemiology and End Results database 2004-2016, we identified intermediate-risk and high-risk white (n = 151 632), Asian (n = 11 189), Hispanic/Latino (n = 20 077) and African American (n = 32 550) localized prostate cancer patients, treated with external beam radiotherapy or radical prostatectomy. Race/ ethnicity-stratified cancer-specific mortality analyses relied on competing risks regression, after propensity score matching for patient and cancer characteristics. Results: Compared with white patients, Asian intermediate-and high-risk external beam radiotherapy patients showed lower cancer-specific mortality (hazard ratio 0.58 and 0.70, respectively, both P ≤ 0.02). Additionally, Asian high-risk radical prostatectomy patients also showed lower cancer-specific mortality than white patients (hazard ratio 0.72, P = 0.04), but not Asian intermediate-risk radical prostatectomy patients (P = 0.08). Conversely, compared with white patients, African American intermediate-risk radical prostatectomy patients showed higher cancer-specific mortality (hazard ratio 1.36, P = 0.01), but not African American high-risk radical prostatectomy or intermediate-and high-risk external beam radiotherapy patients (all P ≥ 0.2). Finally, compared with white people, no cancer-specific mortality differences were recorded for Hispanic/Latino patients after external beam radiotherapy or radical prostatectomy, in both risk levels (P ≥ 0.2). Conclusions: Relative to white patients, an important cancer-specific mortality advantage applies to intermediate-risk and high-risk Asian prostate cancer patients treated with external beam radiotherapy, and to high-risk Asian patients treated with radical prostatectomy. These observations should be considered in pretreatment risk stratification and decision-making.

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Section: Discussionsupporting

confidence: 89%

External beam radiotherapy and radical prostatectomy are associated with better survival in Asian prostate cancer patients

et al. 2021

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“…In addition, despite a significant benefit in PCSS with EBRT + BT in the pooled HR analysis, this was not replicated in the pooled survival curve analysis possibly owing to differences in sample size and heterogeneity. A recent Surveillance, Epidemiology, and End Results (SEER) database study similarly did not identify significant differences in either prostate cancer-specific mortality or overall mortality between EBRT and EBRT + BT on multivariate analysis [30] . Likewise, ASCENDE-RT and other randomized trials have failed to demonstrate an overall survival advantage with the addition of BT boost in high risk prostate cancer, though these studies were not powered to show differences in this endpoint [8] , [9] , [31] , [32] , [33] .…”

Section: Discussionmentioning

confidence: 95%

Does brachytherapy boost improve survival outcomes in Gleason Grade Group 5 patients treated with external beam radiotherapy and androgen deprivation therapy? A systematic review and meta-analysis

Tang¹,

Gulstene²,

McArthur³

et al. 2023

Clinical and Translational Radiation Oncology

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Radiation versus surgery in patients with clinically localized Gleason 9–10 prostate cancer

Guo

Liu

2020

World J Urol

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Surgery associated with increased survival compared to radiation in clinically localized Gleason 9–10 prostate cancer: a SEER analysis

Cited by 5 publications

References 13 publications

External beam radiotherapy and radical prostatectomy are associated with better survival in Asian prostate cancer patients

External beam radiotherapy and radical prostatectomy are associated with better survival in Asian prostate cancer patients

Does brachytherapy boost improve survival outcomes in Gleason Grade Group 5 patients treated with external beam radiotherapy and androgen deprivation therapy? A systematic review and meta-analysis

Radiation versus surgery in patients with clinically localized Gleason 9–10 prostate cancer

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