Surgery and electrochemotherapy treatment of incompletely excised mammary carcinoma in two male pet rats (&lt;i&gt;Rattus norvegicus&lt;/i&gt;)

Lanza, Andrea; Pettorali, Michela; Baldi, Alfonso; Spugnini, Enrico P.

doi:10.1292/jvms.16-0578

Cited by 12 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electrochemotherapy is also being used in the treatment of exotic pets, such as ferrets, cockatiels, turtles, rats, and hedgehogs. [85][86][87][88][89][90][91] Especially in turtles, where fibropapillomatosis is an important cause of morbidity and mortality of sea turtles, electrochemotherapy is a very promising treatment option. Complete responses were obtained after electrochemotherapy with intralesional bleomycin in two treated turtles presenting fibropapillomatosis and one with squamous cell carcinoma, with no healing complications and no recurrence up to 1 year.…”

Section: Studies In Veterinary Oncologymentioning

confidence: 99%

Recent Advances in Electrochemotherapy

Čemažar

Serša

2019

Bioelectricity

View full text Add to dashboard Cite

Electrochemotherapy is gaining recognition as an effective local therapy that uses systemically or intratumorally injected bleomycin or cisplatin with electroporation as a delivery system that brings drugs into the cells to exert their cytotoxic effects. Preclinical work is still ongoing, testing new drugs, seeking the best treatment combination with other treatment modalities, and exploring new sets of pulses for effective tissue electroporation. The applications of electrochemotherapy are being fully exploited in veterinary oncology, where electrochemotherapy, because of its simple execution, has a relatively good cost-benefit ratio and is used in the treatment of cutaneous tumors. In human oncology, electrochemotherapy is fully recognized as a local therapy for cutaneous tumors and metastases. Its effectiveness is being explored in combination with immunomodulatory drugs. However, the development of electrochemotherapy is directed into the treatment of deepseated tumors with a percutaneous approach. Because of the vast number of reports, this review discusses the articles published in the past 5 years.

show abstract

Section: Studies In Veterinary Oncologymentioning

confidence: 99%

Recent Advances in Electrochemotherapy

Čemažar

Serša

2019

Bioelectricity

View full text Add to dashboard Cite

show abstract

“…ECT with intralesional cisplatin has been proven effective and safe for the treatment of equine cutaneous sarcoids, used either as single or adjuvant treatment depending on the studies . Finally, ECT has also been reported for the treatment of miscellaneous tumours in exotic species (ie, ferret and pet rats) with promising results …”

Section: Introductionmentioning

confidence: 99%

“…46,47 Finally, ECT has also been reported for the treatment of miscellaneous tumours in exotic species (ie, ferret and pet rats) with promising results. 48,49 To the best of our knowledge, there are only two papers that investigated ECT on canine sarcomas. 50,51 In the former, 22 dogs with incompletely excised high-grade sarcomas were treated with bleomycin administered in the tumour bed followed by application of biphasic electric pulses.…”

Section: Introductionmentioning

confidence: 99%

Soft tissue sarcoma in dogs: A treatment review and a novel approach using electrochemotherapy in a case series

Torrigiani

Pierini

Lowe

et al. 2019

Vet Comparative Oncology

View full text Add to dashboard Cite

Canine soft tissue sarcomas (STSs) are locally invasive mesenchymal neoplasms. Electrochemotherapy (ECT) is an antitumour local ablative treatment that uses electric pulses to enhance the intracellular delivery of cytotoxic drugs. The aim of this retrospective study was to review the current treatment for STSs and to evaluate the efficacy and safety of ECT with bleomycin in canine STSs. Fifty‐two dogs with 54 STSs were included. Three groups were arranged: (a) ECT alone, (b) intra‐operative ECT and (c) adjuvant ECT. Signalment, tumour size, location, histological grade and margins and ECT parameters were collected. Recurrence rate (RR) and disease‐free interval (DFI) were calculated. Treatment toxicity was assessed using a 6‐point scale. STSs were mostly located on limbs (77.8%). Median tumour size was 4.3 cm (range 0.4‐17.0 cm). Most STSs were grade I (47.7%) and II (50.0%), and histological margins were incomplete in 94.5% of cases. Two complete remissions, one partial remission and one stable disease were recorded in group 1. Group 2 and 3 were similar for tumour location, size and grade, histological margins, treatment toxicity, pulse frequency and voltage. Moreover, RR and DFI were similar between group 2 and 3 (23% and 25%, 81.5 and 243 days, respectively). Local toxicity post ECT was mild (score ≤ 2) in 66.7% of cases. Higher toxicity score was associated with higher pulse voltage (1200 vs 1000 V/cm) (P = 0.0473). ECT coupled with bleomycin resulted safe and efficient in tumour local control and should be considered as an option for treatment of canine STSs.

show abstract

“…In second patient, no tumour regrowth was seen 8 months after treatment. Different studies reported an excellent treatment response of ECT with cisplatin or bleomycin in tumours of different histology with minimal side effects in dogs 10 , 11 , cats 12 , horses 13 , pet rats 14 , and reptiles 15 , 16 . In our cases, only some muscle contractions of the patient were observed during the application of electric pulses.…”

Section: Discussionmentioning

confidence: 99%

“…In animals, pain during ECT can be avoided using sedation and/or general anaesthesia. 10 , 11 , 12 , 13 , 14 , 15 , 16 Gaseous anaesthesia with isoflurane was used in our cases to prevent pain and facilitate proper position of patients for tumour manipulation, the application of chemotherapeutic agent, and positioning of electrodes. Meloxicam, a nonsteroidal anti-inflammatory analgesic was prescribed to the patients before and after ECT to reduce pain and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Electrochemotherapy with bleomycin of different types of cutaneous tumours in a ferret (Mustela putorius furo)

Račnik

Švara

Zadravec

et al. 2017

Radiology and Oncology

View full text Add to dashboard Cite

BackgroundMast cell tumour, sebaceous gland adenoma, and less common squamous papilloma are skin tumours in ferrets (Mustela putorius furo), and early excisional surgery is usually the treatment of choice. The aim of our study was to investigate the effectiveness of electrochemotherapy (ECT), a new, minimally invasive non-surgical method, as first treatment option of different types of ferret skin tumours located on surgically difficult sites.Materials and methodsA 5-year-old castrated male ferret with two cutaneous masses, presenting 4 months apart and a 7-year-old spayed female ferret with two cutaneous masses, that appeared simultaneously on two locations are presented. In the first patient, both masses were diagnosed as mast cell tumours, and in the second patient, squamous papilloma and sebaceous adenoma were diagnosed. One session of ECT with bleomycin injected intratumourally was applied in all tumours.ResultsComplete response (CR) of all tumours was obtained, without recurrence during observation period of 15 months after ECT for first tumour and 11 months after ECT of the tumour located on the right hock in first patient, and 8 months after treatment for the second patient.ConclusionsIn present study, ECT with bleomycin proved to be safe and effective against different cutaneous tumours in ferrets. Due of good results, low cost and relatively easy procedure, ECT could be the treatment of choice instead of surgery for the selected skin tumours in ferrets.

show abstract

Surgery and electrochemotherapy treatment of incompletely excised mammary carcinoma in two male pet rats (<i>Rattus norvegicus</i>)

Cited by 12 publications

References 14 publications

Recent Advances in Electrochemotherapy

Recent Advances in Electrochemotherapy

Soft tissue sarcoma in dogs: A treatment review and a novel approach using electrochemotherapy in a case series

Electrochemotherapy with bleomycin of different types of cutaneous tumours in a ferret (Mustela putorius furo)

Contact Info

Product

Resources

About