Surgery alone or combined with radiation therapy in esophageal carcinoma

Hambraeus, Göran; Mercke, Claes; Hammar, Erik; Landberg, T.; Wang-Andersen, Willy

doi:10.1002/1097-0142(19810701)48:1<63::aid-cncr2820480114>3.0.co;2-6

Cited by 14 publications

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References 24 publications

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“…However, some studies [32] suggest that there is no significant difference in efficacy between radiation prior to surgery and simple surgery. The Esophageal Cancer Society once cited a quantitative meta-analysis from 5 RCTS that got negative results.…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of radiation prior to surgery and chemotherapy on survival of esophageal cancer undergoing surgery

Zhang

Zhang²

2019

Medicine

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Esophageal cancer (EC) is one of the most common cancers in the world, with continuously growing diagnoses and morbidity. Because it is still unclear how to choose the best treatment for EC patients, a multimodal treatment is necessary to improve the prospect of the malignancy, including a sequence of surgery, chemotherapy, and radiotherapy, whether alone or combination. Therefore, this paper aims to analyze the effect of the sequence of chemotherapy, radiotherapy, and surgery on the prognosis and survival rate of patients with EC.The Surveillance, Epidemiology, and End Results (SEER) database was used to extract a dataset of patients who were diagnosed with EC from 1973 to 2015, with follow-up data for 6 years after diagnosis. The data were analyzed using correlation analysis, logistic regression Cox regression, and Kaplan–Meier analysis.EC patients who had radiation prior to surgery and chemotherapy had a better prognosis than the cases without chemotherapy. Based on univariate logistic regression, the odds radios of vital status recoded for “radiation prior to surgery combined with chemotherapy” is the lowest one among the 8 groups classified by radiation sequence with surgery and chemotherapy (P < .001). Further, radiation prior to surgery and chemotherapy is an independent prognostic factor for better survival among EC patients.In conclusion, in the treatment of EC, administering radiation prior to surgery and chemotherapy is better than no radiotherapy, perioperative radiotherapy, postoperative radiotherapy, and other combinations without chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Long-term effects of radiation prior to surgery and chemotherapy on survival of esophageal cancer undergoing surgery

Zhang

Zhang²

2019

Medicine

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Role of Radiation Therapy in Gastrointestinal Cancer

Weissberg¹

1983

Arch Surg

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Prognostic factors influencing survival in combined radiotherapy and surgery of squamous cell carcinoma of the esophagus with special reference to a histopathologic grading system

Hambraeus¹,

Mercke

Wille³

et al. 1988

Cancer

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Sixty-six patients with squamous cell carcinoma of the esophagus were treated with combined surgery and radiotherapy, mostly in a sandwich fashion. Fourteen patients received misonidazole during preoperative radiotherapy. Prospective cumulative survival at 1, 2, and 5 years was 60%, 35%, and 17%, respectively. Original biopsy specimens and operation specimens were evaluated according to a histopathologic grading system based on an evaluation of the tumor cell population in terms of cell differentiation, structure, nuclear polymorphism, and the frequency of mitotic figures. The tumor-host relationship was also estimated by the mode of invasion, stage of invasion, vascular invasion, and degree of lymphocytic infiltration. A multivariate regres$ion analysis according to Cox and actuarial survival were used to determine the relative contributions of the clinical and histopathologic parameters to patient outcome. The major results were as follows: (1) patients who were old (70 to 80 years) fared as well as younger patients (P = 0.9198); (2) tumor site did not influence therapeutic outcome (P = 0.1100); (3) there was an insignificant difference in survival between patients with MO and MI disease (P = 0.7130); (4) radical surgery gave better survival; (5) misonidazole administered preoperatively was associated with worse survival (P = 0.0147); and (6) the histopathologic malignancy grading score system was very useful for prognostication-the tumor-host score in the operative specimen was the strongest of all analyzed predictive parameters. Since palliation was excellent in all patients treated in the combined fashion, selection criteria should be wide for such a program, not the least since long-term survival is possible also for patients with very advanced tumors.Cancer 62:895-904, 1988.PIDERMOID CARCINOMA O f the esophagus is a E highly aggressive tumor with a poor prognosis. No general agreement has been reached as to optimal treatment for patients with this disease or as to whether the main goal should be cure or palliati~n.'-~ Radical treatment has been attempted with surgery, radiotherapy, combined radiotherapy and surgery, or a trimodal regime incorporating ~h e m o t h e r a p y .~-~ TreatmentFrom the

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Surgery alone or combined with radiation therapy in esophageal carcinoma

Cited by 14 publications

References 24 publications

Long-term effects of radiation prior to surgery and chemotherapy on survival of esophageal cancer undergoing surgery

Long-term effects of radiation prior to surgery and chemotherapy on survival of esophageal cancer undergoing surgery

Role of Radiation Therapy in Gastrointestinal Cancer

Prognostic factors influencing survival in combined radiotherapy and surgery of squamous cell carcinoma of the esophagus with special reference to a histopathologic grading system

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