Surge of mucormycosis during the COVID-19 pandemic

Dam, Paulami; Cardoso, Marlon Henrique; Mandal, Sukhendu; Franco, Octávio Luiz; Sağıroğlu, Pınar; Polat, Osman Ahmet; Kökoğlu, Kerem; Mandal, Amit Kumar; Öçsoy, İsmail

doi:10.1016/j.tmaid.2023.102557

Travel Medicine and Infectious Disease

2023

DOI: 10.1016/j.tmaid.2023.102557

|View full text |Cite

Surge of mucormycosis during the COVID-19 pandemic

Paulami Dam

Marlon Henrique Cardoso

Sukhendu Mandal

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article6

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 24 publications

(27 citation statements)

References 162 publications

(255 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, CAM cases may be higher than the described ones. 4 Patients with COVID-19 treated with intensive care support are prone to nosocomial and ventilator-associated infections. 4 , 13 …”

mentioning

confidence: 99%

“…The authors cited preemptive therapy in a patient with features suggesting mucormycosis. 9 Dam et al 4 reviewed the pathogenesis, causal agents, determinants, distributions, manifestations, virulence factors, case reports, diagnosis, and treatment related to the increasing trend of mucormycosis in several countries and the COVID-19 co-infections. The study comprised 388 cases and showed 46.7% of global mortality; 56.8% of the cases were associated with uncontrolled diabetes and 10.2% with trauma, the majority of cases and the higher mortality rate were observed in North India (82.7%).…”

mentioning

confidence: 99%

“…The study comprised 388 cases and showed 46.7% of global mortality; 56.8% of the cases were associated with uncontrolled diabetes and 10.2% with trauma, the majority of cases and the higher mortality rate were observed in North India (82.7%). 4 GI infection was uncommon and with nonspecific symptoms, affecting the large intestine (∼43.2%), stomach (∼33%) often in adults, and small intestine (∼28.4%), mainly in children. The mortality was 96% in disseminated, 85% in GI, and 76% in pulmonary infections.…”

mentioning

confidence: 99%

“…The mortality was 96% in disseminated, 85% in GI, and 76% in pulmonary infections. 4 The authors stressed the risk of improper use of antifungal drugs for the mucormycosis surge in the present pandemic, which might contribute to antifungal resistance over time. 4 Didehdar et al 5 reviewed 87 reports of GI mucormycosis from 2015 to November 2021, including 70 adults and ten neonatal patients, the majority of cases (57.5%) from Asia.…”

mentioning

confidence: 99%

“… 4 The authors stressed the risk of improper use of antifungal drugs for the mucormycosis surge in the present pandemic, which might contribute to antifungal resistance over time. 4 Didehdar et al 5 reviewed 87 reports of GI mucormycosis from 2015 to November 2021, including 70 adults and ten neonatal patients, the majority of cases (57.5%) from Asia. The mortality rate of neonatal patients was 70%, the other cases had a mortality rate of 44%; corticosteroid use and diabetes were the main risk factors, 11% were immunocompetent, and four of the adults presented with specific positivity tests of COVID-19 infection.…”

mentioning

confidence: 99%

See 4 more Smart Citations

COVID-19 associated mucormycosis a recent challenge

Santos¹,

Santos²,

Sugai³

2023

Autops Case Rep

View full text Add to dashboard Cite

“…Thus, CAM cases may be higher than the described ones. 4 Patients with COVID-19 treated with intensive care support are prone to nosocomial and ventilator-associated infections. 4 , 13 …”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

COVID-19 associated mucormycosis a recent challenge

Santos¹,

Santos²,

Sugai³

2023

Autops Case Rep

View full text Add to dashboard Cite

A Novel Biomaterial for Decolorization of Azo Dyes: Myoglobin‐Zn(II) Assisted Hybrid Nanoflowers

Altınkaynak

Turk

Yangin

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

Protein‐inorganic hybrid nanoflowers are new multifunctional materials shown enhanced catalytic performance. Specially, they are used as catalyst and dye decolorizer via Fenton reaction. In this study, the Myoglobin‐Zn (II) assisted hybrid nanoflowers (MbNFs@Zn) were fabricated by using myoglobin and zinc (II) ions in different synthesis conditions. The optimum morphology was characterized SEM, TEM, EDX, XRD, and FT‐IR. The hemisphere and uniform morphology was obtained at pH 6 and 0.1 mg mL−1. The size of MbNFs@Zn are 5–6 μm. The encapsulation yield was ∼95 %. In the presence of H2O2, the peroxidase mimic activity of MbNFs@Zn was spectrophotometrically investigated in the different pH values (4–9). The highest peroxidase mimic activity was found as 3.378 EU/mg at pH 4. MbNFs@Zn was exhibited 0.28 EU/mg after eight cycles. MbNFs@Zn has lost about 92 % of its activity. The usability of MbNFs@Zn for decolorization of azo dyes such as Congo red (CR), and Evans blue (EB) was researched at different times, temperatures and concentrations. The decolorization efficiency was found maximum as 92.3 % and 88.4 % for EB and CR dyes, respectively. MbNFs@Zn has perfect properties such as enhanced catalytic performance, high decolorization efficiency, stability and reusability, and can be excellent potential materials for many industrial applications.

show abstract

Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis

El-Sayed,

Abdelaziz,

El-Housseiny

et al. 2024

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate (ODHP) was extracted in a previous study from the culture broth of soil isolate Alcaligenes faecalis MT332429 and showed a promising antimycotic activity. This study was aimed to formulate ODHP loaded β-cyclodextrins (CD) nanosponge (NS) hydrogel (HG) to control skin fungal ailments since nanosponges augment the retention of tested agents in the skin. Box-Behnken design was used to produce the optimized NS formulation, where entrapment efficiency percent (EE%), polydispersity index (PDI), and particle size (PS) were assigned as dependent parameters, while the independent process parameters were polyvinyl alcohol % (w/v %), polymer-linker ratio, homogenization time, and speed. The carbopol 940 hydrogel was then created by incorporating the nanosponges. The hydrogel fit Higuchi’s kinetic release model the best, according to in vitro drug release. Stability and photodegradation studies revealed that the NS-HG remained stable under tested conditions. The formulation also showed higher in vitro antifungal activity against Candida albicans compared to the control fluconazole. In vivo study showed that ODHP-NS-HG increased survival rates, wound contraction, and healing of wound gap and inhibited the inflammation process compared to the other control groups. The histopathological examinations and Masson’s trichrome staining showed improved healing and higher records of collagen deposition. Moreover, the permeability of ODHP-NS-HG was higher through rats’ skin by 1.5-folds compared to the control isoconazole 1%. Therefore, based on these results, NS-HG formulation is a potential carrier for enhanced and improved topical delivery of ODHP. Our study is a pioneering research on the development of a formulation for ODHP produced naturally from soil bacteria. Key points • Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate was successfully formulated as a nanosponge hydrogel and statistically optimized. • The new formula exhibited in vitro good stability, drug release, and higher antifungal activity against C. albicans as compared to the fluconazole. • Ex vivo showed enhanced skin permeability, and in vivo analysis showed high antifungal activity as evidenced by measurement of various biochemical parameters and histopathological examination.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Surge of mucormycosis during the COVID-19 pandemic

Cited by 24 publications

References 162 publications

COVID-19 associated mucormycosis a recent challenge

COVID-19 associated mucormycosis a recent challenge

A Novel Biomaterial for Decolorization of Azo Dyes: Myoglobin‐Zn(II) Assisted Hybrid Nanoflowers

Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis

Contact Info

Product

Resources

About