Surfactants of microbial origin as antibiofilm agents

Paraszkiewicz, Katarzyna; Moryl, Magdalena; Płaza, Grażyna; Bhagat, Diksha; Satpute, Surekha K.; Bernat, Przemysław

doi:10.1080/09603123.2019.1664729

Cited by 48 publications

(32 citation statements)

References 102 publications

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“…In this scenario, BSs effectively appear to be promising new candidates for biofilm inhibition in the biomedical field due to their interesting antimicrobial, anti-adhesive properties (Banat et al, 2010;Rodrigues and Teixeira, 2010;Fracchia et al, 2019;Naughton et al, 2019). These molecules, in fact, are able to counteract effectively biofilms by decreasing microbial cells viability and by reducing microbial adhesion (Satpute et al, 2016;Fracchia et al, 2019;Paraszkiewicz et al, 2019;Naughton et al, 2019). When BSs bind to cell wall surface, they may form a film that changes the wettability and the surface energy of the cell leading to severe changes in its hydrophobicity and increasing its permeability by the release of LPS and the formation of transmembrane pores.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Lipopeptides and Glycolipids on C. albicans–Staphylococcus spp. Dual-Species Biofilms

et al. 2021

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Microbial biofilms strongly resist host immune responses and antimicrobial treatments and are frequently responsible for chronic infections in peri-implant tissues. Biosurfactants (BSs) have recently gained prominence as a new generation of anti-adhesive and antimicrobial agents with great biocompatibility and were recently suggested for coating implantable materials in order to improve their anti-biofilm properties. In this study, the anti-biofilm activity of lipopeptide AC7BS, rhamnolipid R89BS, and sophorolipid SL18 was evaluated against clinically relevant fungal/bacterial dual-species biofilms (Candida albicans, Staphylococcus aureus, Staphylococcus epidermidis) through quantitative and qualitative in vitro tests. C. albicans–S. aureus and C. albicans–S. epidermidis cultures were able to produce a dense biofilm on the surface of the polystyrene plates and on medical-grade silicone discs. All tested BSs demonstrated an effective inhibitory activity against dual-species biofilms formation in terms of total biomass, cell metabolic activity, microstructural architecture, and cell viability, up to 72 h on both these surfaces. In co-incubation conditions, in which BSs were tested in soluble form, rhamnolipid R89BS (0.05 mg/ml) was the most effective among the tested BSs against the formation of both dual-species biofilms, reducing on average 94 and 95% of biofilm biomass and metabolic activity at 72 h of incubation, respectively. Similarly, rhamnolipid R89BS silicone surface coating proved to be the most effective in inhibiting the formation of both dual-species biofilms, with average reductions of 93 and 90%, respectively. Scanning electron microscopy observations showed areas of treated surfaces that were free of microbial cells or in which thinner and less structured biofilms were present, compared to controls. The obtained results endorse the idea that coating of implant surfaces with BSs may be a promising strategy for the prevention of C. albicans–Staphylococcus spp. colonization on medical devices, and can potentially contribute to the reduction of the high economic efforts undertaken by healthcare systems for the treatment of these complex fungal–bacterial infections.

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Lipopeptides and Glycolipids on C. albicans–Staphylococcus spp. Dual-Species Biofilms

et al. 2021

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“…BSs inhibit biofilms both by decreasing microbial cell viability and reducing microbial adhesion [ 16 , 25 , 68 , 97 , 98 , 99 ] ( Figure 2 ). The antibiofilm activity of BSs is not only associated with their antimicrobial action by the mechanisms previously described, but it is also related to their ability to form cavities within the biofilm structure [ 100 ] and to interfere with quorum sensing signaling and gene expression [ 101 , 102 ].…”

Section: Antiadhesive and Antibiofilm Activity Of Bssmentioning

confidence: 99%

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

et al. 2021

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The spread of antimicrobial-resistant pathogens typically existing in biofilm formation and the recent COVID-19 pandemic, although unrelated phenomena, have demonstrated the urgent need for methods to combat such increasing threats. New avenues of research for natural molecules with desirable properties to alleviate this situation have, therefore, been expanding. Biosurfactants comprise a group of unique and varied amphiphilic molecules of microbial origin capable of interacting with lipidic membranes/components of microorganisms and altering their physicochemical properties. These features have encouraged closer investigations of these microbial metabolites as new pharmaceutics with potential applications in clinical, hygiene and therapeutic fields. Mounting evidence has indicated that biosurfactants have antimicrobial, antibiofilm, antiviral, immunomodulatory and antiproliferative activities that are exploitable in new anticancer treatments and wound healing applications. Some biosurfactants have already been approved for use in clinical, food and environmental fields, while others are currently under investigation and development as antimicrobials or adjuvants to antibiotics for microbial suppression and biofilm eradication strategies. Moreover, due to the COVID-19 pandemic, biosurfactants are now being explored as an alternative to current products or procedures for effective cleaning and handwash formulations, antiviral plastic and fabric surface coating agents for shields and masks. In addition, biosurfactants have shown promise as drug delivery systems and in the medicinal relief of symptoms associated with SARS-CoV-2 acute respiratory distress syndrome.

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“…Some Candida species ( Candida apicola , Stramerella bombicola and Rhodotorula bogoriensis ) produce sophorolipids that have anti-biofilm activity. Their surfactant properties inhibit the adhesion, biofilm formation and cause dispersion of mature biofilms of Candida and Pichia species and Gram-positive bacteria [ 162 ]. Surfactants of different ecological origins (fungal and bacterial) carried-on to honey might act synergistically, adding to honey’s known anti-biofilm effect [ 163 , 164 ].…”

Section: Antimicrobial Compounds Produced By Bacillus Sppmentioning

confidence: 99%

Honey as an Ecological Reservoir of Antibacterial Compounds Produced by Antagonistic Microbial Interactions in Plant Nectars, Honey and Honey Bee

Brudzynski

2021

Antibiotics

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The fundamental feature of “active honeys” is the presence and concentration of antibacterial compounds. Currently identified compounds and factors have been described in several review papers without broader interpretation or links to the processes for their formation. In this review, we indicate that the dynamic, antagonistic/competitive microbe–microbe and microbe–host interactions are the main source of antibacterial compounds in honey. The microbial colonization of nectar, bees and honey is at the center of these interactions that in consequence produce a range of defence molecules in each of these niches. The products of the microbial interference and exploitive competitions include antimicrobial peptides, antibiotics, surfactants, inhibitors of biofilm formation and quorum sensing. Their accumulation in honey by horizontal transfer might explain honey broad-spectrum, pleiotropic, antibacterial activity. We conclude that honey is an ecological reservoir of antibacterial compounds produced by antagonistic microbial interactions in plant nectars, honey and honey bee. Thus, refocusing research on secondary metabolites resulting from these microbial interactions might lead to discovery of new antibacterial compounds in honey that are target-specific, i.e., acting on specific cellular components or inhibiting the essential cellular function.

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Surfactants of microbial origin as antibiofilm agents

Cited by 48 publications

References 102 publications

Inhibitory Effects of Lipopeptides and Glycolipids on C. albicans–Staphylococcus spp. Dual-Species Biofilms

Inhibitory Effects of Lipopeptides and Glycolipids on C. albicans–Staphylococcus spp. Dual-Species Biofilms

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

Honey as an Ecological Reservoir of Antibacterial Compounds Produced by Antagonistic Microbial Interactions in Plant Nectars, Honey and Honey Bee

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