Surfactants and Block Copolymers in Drug Delivery

Surfactant and Block Copolymer Nanostructures: From Design and Development to Nanomedicine Preclinical Studies

“…In one example the use of Pluronics, along with liquid crystalline phases based on glycerate surfactants in an injectable final formulation, achieved the controlled release of a variety of hydrophilic and hydrophobic compounds such as paclitaxel, irinotecan and octreotide. In other studies, the combination of Pluronic P123 and the nonionic surfactant Span 65 was able to formulate stable, spherical, small diameter vesicles at mild conditions in aqueous solutions and with relative ease [ 52 , 53 , 54 ]).…”

Aggregation in Deep Eutectic Solvents (DESs): Formation of Polar DES-in-Nonpolar DES Microemulsions

“…Microemulsions (MEs) are optically transparent thermodynamically stable compartmentalized dispersions usually consisting of two immiscible liquids (one polar and the other nonpolar) formed using an emulsifying agent, preferably a surfactant. − Since their advent, such spontaneously formed aggregated assemblies have demonstrated applications in several areas, most notable being biochemistry, nanotechnology, synthesis, extraction, separation, oil recovery, polymerization, pharmaceutical, cosmetic, agrochemical, and food industries. − The initial reports on MEs invariably involved water as the polar phase, and based on the relative amount of water, the MEs were characterized as oil-in-water (o/w) or water-in-oil (w/o) with mostly conventional organic solvent as the oil phase . The w/o MEs perhaps have garnered more attention due to the stabilization of water droplets within the bulk nonpolar “oil” using a surfactant offering plethora of applications. , The water intake (or loading), which controls the crucial properties, such as size and shape of w/o MEs, is characterized in terms of w o = [water]/[surfactant] …”

Chelating Complex Micelles for Delivering Cytoprotectant Amifostine and its Application in Radiation Protection

“…Polymeric micelles, which are commonly formed by amphiphilic block copolymers, demonstrate excellent potential in the field of DDS. Nano-scaled micelles were designed to extend the half-lives of drugs and reduce the uptake by reticuloendothelial system (RES) [1]. Drugs can be loaded into polymeric micelles through physical encapsulation, covalent bonding, or electrostatic interactions.…”