Surfactant therapy for pneumonia COVID-19 of obstetric patients

Shvechkova, M.V.; Kukarskaya, I.I.; Баутин, А. Е.; Legalova, T. V.; Marchenko, R.N.; Shvechkova, A. S.; Kukarskaya, E. Yu.; Yakovleva, E. A.

doi:10.21518/2079-701x-2022-16-4-66-73

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Тяжесть и длительность заболевания зависят от множества факторов: неспецифической резистентности организма собаки, массовой инвазии и патогенности возбудителя, возраста животного, преморбидного и сопутствующего статуса. По данным О. Г. Швечковой [41], летальность животных в крупных городах составляет 14,5%.…”

Section: материалы и методы / Materials and Methodsunclassified

“…Уровень эозинофилов слегка увеличен (lim 0- В других исследованиях [27,31,41] тенденция изменения биохимических показателей при лептоспирозе у собак соответствует нашим данным. Изменения биохимических показателей крови на 9 и 18 день болезни представлены в таблице 4.…”

Section: материалы и методы / Materials and Methodsunclassified

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Heuristic approaches to risk assessment and prognosis of sepsis in dogs

Laptev,

Pimenov,

Mazanova

et al. 2023

jour

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This study examines approaches to assessing the risk of death and predicting the development of sepsis in dogs. Sepsis remains one of the key clinical problems in medicine and veterinary medicine, due to its widespread prevalence throughout the world, leading to high mortality. Sepsis is based on the reaction of systemic inflammation of the body, which is realized in the presence of signs of SIRS, bacteremia and/or an infectious focus of various nature in combination with acute signs of organ dysfunction and/or evidence of microbial dissemination. Since sepsis develops only progressively, it is impossible for the animal to recover independently without providing it with timely and appropriate medical care. Today, one of the key issues remains improving approaches to assessing the risk of death and predicting the development of sepsis in dogs. An attempt to combine the pathogenicity factors of an infectious agent and the failure of the host’s defense mechanisms is reflected in the concepts of PIRO, SAPS and MODS, which evaluate the links in the etiopathogenesis of sepsis. Thus, heuristic approaches will allow us to come closer to the development of pathogenetically based methods for assessing the risk of death of animals and predicting the development of sepsis in dogs. These approaches are based on criteria for assessing PIRO indicators: predisposition (P), including breed, sex, age of the animal; infection (I) associated with the type of pathogen detected; systemic response of the body to infection R, characterized by the main clinical indicators - body temperature, heart rate, respiratory rate and the number of leukocytes in the blood; organ dysfunction (O) identified in one or more organs of the animal. An important role in the objective prognosis is given to the evaluation criteria on the SAPS scale, taking into account changes in indicators towards hyperinflammation (SIRS) or immunosuppression (MODS), which determine the stage of development of sepsis and the likelihood of the risk of death of the sick animal. On average, the predictive accuracy of quantifying disease severity systems is 70–85%. An algorithm for translating clinical and laboratory data into a SAPS scale of indicators (scores) that determines the severity of the disease in leptospirosis in dogs is proposed. It has been shown that on the SAPS scale for canine leptospirosis, a score of 29

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Section: материалы и методы / Materials and Methodsunclassified

Heuristic approaches to risk assessment and prognosis of sepsis in dogs

Laptev,

Pimenov,

Mazanova

et al. 2023

jour

View full text Add to dashboard Cite

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Complex treatment of destructive pulmonary tuberculosis using inhaled tauractant therapy

Tatarintseva,

Batishcheva,

Demidkov

et al. 2023

Medicinskij sovet

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Introduction. Chemotherapy is the main component used in the treatment of tuberculosis. In addition to chemotherapy, pathogenetic treatment holds a special place in the complex treatment. The inhaled tauractant therapy restores phospholipid content on the surface of the alveolar epithelium, stimulates the involvement of additional lung parenchyma areas in breathing, facilitates elimination of toxic substances together with sputum from the alveolar space and protects the alveolar epithelium against injury caused by chemical and physical agents. Thereby it promotes acceleration of the lung parenchyma recovery processes.Aim. To study the experience of using Surfactant-BL in patients with destructive pulmonary tuberculosis receiving a standard chemotherapy regimen, taking into account the drug susceptibility for Mycobacterium tuberculosis.Materials and methods. A study was conducted involving 10 patients with destructive pulmonary tuberculosis who were diagnosed with it for the first time in their lives. They received treatment in Respiratory Tuberculosis Patients Department No. 4 of the Budgetary Healthcare Institution of Omsk Region – Clinical TB Dispensary in 2022–2023.Results. Tauractant showed a pronounced positive effect on the destructive tuberculosis process in patients who already received a standard chemotherapy regimen. Inhaled therapy promoted acceleration of the cavity closure.Conclusion. The addition of inhaled tauractant therapy to the standard chemotherapy regimen in patients with multidrug resistance (MDR) and pre-extensively drug-resistant (pre-XDR) respiratory TB significantly accelerated the TB cavity closure. The severity of intoxication and respiratory syndrome decreased in terms of clinical symptoms (relief of shortness of breath and cough). Spirography showed an increase in major indices of the pulmonary function test monitored at 2and 4-month follow-up.

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Surfactant therapy for pneumonia COVID-19 of obstetric patients

Cited by 2 publications

References 25 publications

Heuristic approaches to risk assessment and prognosis of sepsis in dogs

Heuristic approaches to risk assessment and prognosis of sepsis in dogs

Complex treatment of destructive pulmonary tuberculosis using inhaled tauractant therapy

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