Surfactant protein-D and exposure to bioaerosols in wastewater and garbage workers

Tabrizi, R. Daneshzadeh; Bernard, Alfred; Thommen, A. M.; Winter, F De; Oppliger, Anne; Hilfiker, Silvia; Tschopp, Alois; Hotz, Peter Eggenberger

doi:10.1007/s00420-010-0525-3

Cited by 16 publications

(13 citation statements)

References 27 publications

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“…This is in line with the results from the baseline section of the study, which used life-long exposure duration as the exposure metric 1 3. Regarding SP-D, the slight increase found in wastewater workers may be due to short but high exposures to endotoxin during special tasks and may represent a subclinical inflammatory reaction with slightly increased permeability of the lung–blood barrier.…”

Section: Discussionsupporting

confidence: 85%

“…Mean exposure to endotoxin varied considerably in wastewater workers (up to 500 EU/m 3 ) but was low in garbage collectors and controls 1 9…”

Section: Resultsmentioning

confidence: 98%

“…Loss of power because of misclassifications due to natural test variability or exposure changes was unlikely as FEV 1 was measured annually over 5 years11 12 and occupational changes recorded during follow-up. Therefore, the most likely explanation for these findings is that no effect was found because the exposure was in the lower range of the dose–effect relationship 1 3 4…”

Section: Discussionmentioning

confidence: 99%

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Exposure to bioaerosols, respiratory health and lung-specific proteins: a prospective study in garbage and wastewater workers: Table 1

et al. 2011

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Section: Discussionsupporting

confidence: 85%

“…Mean exposure to endotoxin varied considerably in wastewater workers (up to 500 EU/m 3 ) but was low in garbage collectors and controls 1 9…”

Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Exposure to bioaerosols, respiratory health and lung-specific proteins: a prospective study in garbage and wastewater workers: Table 1

et al. 2011

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“…15 This finding was in accord to the potential of bio-aerosol to produce bronchial and respiratory tract hyper-responsiveness and allergic reactions mentioned earlier. 12,19,20 Conflicts of Interest: None declared.…”

Section: Vcmentioning

confidence: 99%

Respiratory Disorders Associated with Occupational Inhalational Exposure to Bioaerosolsamong Wastewater Treatment Workers of Petrochemical Complexes

Jahangiri¹,

Neghab²,

Nasiri³

et al. 2015

Int J Occup Environ Med

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“…Higher concentrations of CC16 compared to a control group were found among sewage workers (Steiner et al 2005), and a lower SP-A was found among asthmatic workers (Widmeier et al 2007). However, no associations between the exposure measurements and surfactant proteins were reported (Steiner et al 2005; Widmeier et al 2007; Tabrizi et al 2010; Tchopp et al 2011). …”

Section: Introductionmentioning

confidence: 99%

Pneumoproteins in sewage workers exposed to sewage dust

Heldal

Barregård

Larsson

et al. 2012

Int Arch Occup Environ Health

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PurposeThe association between exposure to bacteria and endotoxins in sewage dust and the serum concentrations of pneumoproteins in sewage treatment plant workers were studied.MethodsForty-four workers from eight sewage treatment plants and 38 reference workers participated in the study. Microbial aerosol was collected by personal inhalable samplers. The concentrations of bacteria and endotoxins were determined by fluorescence microscopy and the Limulus assay, respectively. Pneumoproteins (Clara cell protein: CC16, and Surfactant proteins A and D: SP-A, SP-D) were determined by ELISA in blood samples collected post-shift.ResultsThe exposure to dust ranged from 0.02 to 9.3 (geometric mean (GM) 0.3 mg/m3, of bacteria from 0.3 to 4,900 × 103 (GM 27 × 103) cells/m3 and endotoxins from 1 to 3,160 (GM 28) EU/m3. The exposed workers had lower CC16 [arithmetic mean (AM) 4.9 ng/ml] compared to the referents (AM 6.4 ng/ml, p < 0.01). No significant difference was observed for SP-D and SP-A. Exposure to bacteria was positively associated with CC16 (p < 0.05) and SP-D (p < 0.05), adjusting for possible confounders.ConclusionsThis study showed that exposed workers had lower serum concentration of CC16 as compared to the referents, which may reflect a long-term effect on secretion of these pneumoproteins. The positive association between exposure to bacteria and the serum concentrations of CC16 and SP-D may be explained by a transient increased permeability of the lung–blood barrier.

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Surfactant protein-D and exposure to bioaerosols in wastewater and garbage workers

Abstract: These results support the hypothesis that inhalation of bioaerosols, even at low concentrations, has a subclinical effect on the lung-blood barrier, the permeability of which increases without associated spirometric changes.

Cited by 16 publications

References 27 publications

Exposure to bioaerosols, respiratory health and lung-specific proteins: a prospective study in garbage and wastewater workers: Table 1

Exposure to bioaerosols, respiratory health and lung-specific proteins: a prospective study in garbage and wastewater workers: Table 1

Respiratory Disorders Associated with Occupational Inhalational Exposure to Bioaerosolsamong Wastewater Treatment Workers of Petrochemical Complexes

Pneumoproteins in sewage workers exposed to sewage dust

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