Surfactant phospholipid composition of gastric aspirate samples differs between male and female very preterm infants

Sozo, Foula; Ishak, Noreen; Bhatia, Risha; Davis, Peter G; Harding, Richard

doi:10.1038/pr.2017.147

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…According to Sozo et al . 54 , pulmonary surfactant is composed mostly of phospholipids such as PC(32:0), PC(36:1), PI(34:1), PI(38:3), PS(36:1) and PS(40:6). So except for PI(34:1) and PS(40:6), all these lipids were detected in the swine fetal lungs.…”

Section: Discussionmentioning

confidence: 99%

Metabolites and Lipids Associated with Fetal Swine Anatomy via Desorption Electrospray Ionization – Mass Spectrometry Imaging

León

Ferreira

Eberlin

et al. 2019

Sci Rep

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Chemical imaging by mass spectrometry (MS) has been largely used to study diseases in animals and humans, especially cancer; however, this technology has been minimally explored to study the complex chemical changes associated with fetal development. In this work, we report the histologically-compatible chemical imaging of small molecules by desorption electrospray ionization (DESI) - MS of a complete swine fetus at 50 days of gestation. Tissue morphology was unperturbed by morphologically-friendly DESI-MS analysis while allowing detection of a wide range of small molecules. We observed organ-dependent localization of lipids, e.g . a large diversity of phosphatidylserine lipids in brain compared to other organs, as well as metabolites such as N-acetyl-aspartic acid in the developing nervous system and N-acetyl-L-glutamine in the heart. Some lipids abundant in the lungs, such as PC(32:0) and PS(40:6), were similar to surfactant composition reported previously. Sulfatides were highly concentrated in the fetus liver, while hexoses were barely detected at this organ but were abundant in lung and heart. The chemical information on small molecules recorded via DESI-MS imaging coupled with traditional anatomical evaluation is a powerful source of bioanalytical information which reveals the chemical changes associated with embryonic and fetal development that, when disturbed, causes congenital diseases such as spina bifida and cleft palate.

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Section: Discussionmentioning

confidence: 99%

Metabolites and Lipids Associated with Fetal Swine Anatomy via Desorption Electrospray Ionization – Mass Spectrometry Imaging

León

Ferreira

Eberlin

et al. 2019

Sci Rep

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“…Furthermore, sex differences in lung development and in the respiratory transition at birth are seen in humans and sheep, especially following preterm birth (431). These sex differences in lung function at birth reflect differences in the maturation of pulmonary surfactant composition, rather than differences in lung architecture, in preterm infants (210,410).…”

Section: Fact 5: Development Of Major Organ and Regulatory Systems Occurs Before And Around Birth In Sheep As In Humans But After Birth Imentioning

confidence: 96%

Improving pregnancy outcomes in humans through studies in sheep

Morrison

Berry

Botting

et al. 2018

American Journal of Physiology-Regulatory, Integrative and Comp

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123

133

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Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base for translation of interventions to the clinic. The aim of this review is to highlight the advances in perinatal human medicine that have been achieved following translation of research using the pregnant sheep and fetus.

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“…Besides, the various components of pulmonary surfactants are relative to GA and sex. At 25 weeks of gestation, the proportion of dipalmitoyl phosphatidylcholine in males was lower than in females; while at 30 to 40 weeks of gestation, the concentration of saturated phosphatidylcholine and the proportion of unsaturated phosphatidylcholine in males were also lower than in females ( 34 , 35 ). Sex hormones are also key to lung development.…”

Section: Discussionmentioning

confidence: 91%

Increased Risk for Respiratory Complications in Male Extremely Preterm Infants: A Propensity Score Matching Study

Lin

Fan

et al. 2022

Front. Endocrinol.

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BackgroundMany factors can affect the clinical outcome of extremely premature infants (EPIs), but the effect of sex is paradoxical. This study used propensity score matching to adjust baseline information to reassess the clinical outcome of EPIs based on sex.MethodsA retrospective analysis was performed on EPIs admitted in the Department of Neonatology of the Third Affiliated Hospital of Guangzhou Medical University from 2011 to 2020. A propensity score matching (PSM) analysis was used to adjust the confounding factors including gestational age, birth weight, 1-minute Apgar score ≤ 3, withholding or withdrawing life-sustaining treatment(WWLST), mechanical ventilation, duration of mechanical ventilation, the mother with advanced age (≥35 years old), complete-course antenatal steroid therapy and hypertensive disorders of pregnancy. The survival rate at discharge and the incidence of major complications were evaluated between the male and female groups.ResultsA total of 439 EPIs were included, and 240 (54.7%) infants were males. After matching the nine confounding factors, 148 pairs of infants were finally enrolled. There was no significant difference in the survival rate at discharge, as well as the mortality of activating treatment or WWLST between the two groups (all P>0.05). However, the incidence of respiratory distress syndrome, bronchopulmonary dysplasia (BPD), and moderate to severe BPD in the male group was significantly increased (all P<0.01), especially at birth weight between 750 and 999 grams.ConclusionsThe male EPIs have a higher risk of respiratory complications than females, particularly at 750 to 999 grams of birth weight.

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Surfactant phospholipid composition of gastric aspirate samples differs between male and female very preterm infants

Cited by 8 publications

References 40 publications

Metabolites and Lipids Associated with Fetal Swine Anatomy via Desorption Electrospray Ionization – Mass Spectrometry Imaging

Metabolites and Lipids Associated with Fetal Swine Anatomy via Desorption Electrospray Ionization – Mass Spectrometry Imaging

Improving pregnancy outcomes in humans through studies in sheep

Increased Risk for Respiratory Complications in Male Extremely Preterm Infants: A Propensity Score Matching Study

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