Surfactant-Mediated Dissolution of Metformin Hydrochloride Tablets: Wetting Effects Versus Ion Pairs Diffusivity

Desai, Divyakant; Wong, Benjamin C.Y.; Huang, Yande; Ye, Qingmei; Tang, Dan; Guo, Hang; Huang, Ming; Timmins, Peter

doi:10.1002/jps.23852

Cited by 57 publications

(35 citation statements)

References 20 publications

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“…In our case, it can be hypothesized that the presence of DCP or SDC can reduce the MTF solubility by forming poorly soluble salts, as observed for other anionic surfactants (Desai et al, 2014). This effect, combined to the more dense mesh covering obtained with increasing the CS amount, can reduce the drug escaping from the vesicle, thus improving drug loading.…”

Section: Chitosomespreparation and Characterizationmentioning

confidence: 56%

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

Maestrelli

Mura

González-Rodrı́guez

et al. 2017

International Journal of Pharmaceutics

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Section: Chitosomespreparation and Characterizationmentioning

confidence: 56%

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

Maestrelli

Mura

González-Rodrı́guez

et al. 2017

International Journal of Pharmaceutics

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“…The aqueous solubility of metformin is 300 mg/mL within the pH range of 1.2-6.8. It is slightly soluble in alcohol, practically insoluble in acetone and dichloromethane (Sweetman, 2007;Raghuwanshi et al, 2010;Raparla & Talasila, 2012;Desai et al, 2014). Its melting point is between 222-226 C. Metformin should be preserved in light-resistant and wellclosed containers in room temperature (Food and Drug Administration, 2015).…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Çetin

Şahin

2015

Drug Delivery

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Context: Metformin hydrochloride is a biguanide derivative widely used for the treatment of type 2 diabetes, prescribed nearly to 120 million people worldwide. Metformin has a relatively low oral bioavailability (about 50-60%). Although the major effect of metformin is to decrease hepatic glucose output as an antihyperglycemic agent, its inhibitory effects on the proliferation of some cancer cells (e.g. prostate, breast, glioma cells) have been demonstrated in the cell culture studies. Development of novel formulation (e.g. microparticles, nanoparticles) strategies for metformin might be useful to improve its bioavailability, to reduce the dosing frequency, to decrease gastrointestinal side effects and toxicity and to be helpful for effective use of metformin in cancer treatment. Objective: The main aim of this review is to summarize metformin HCl-loaded micro-and nanoparticulate drug delivery systems. Method: The literature was rewieved with regard to the physicochemical, pharmacological properties of metformin, and also its mechanism of action in type 2 diabetes and cancer. In addition, micro-and nanoparticulate drug delivery systems developed for metformin were gathered from the literature and the results were discussed. Conclusion: Metformin is an oral antihyperglycemic agent and also has potential antitumorigenic effects. The repeated applications of high doses of metformin (as immediate release formulations) are needed for an effective treatment due to its low oral bioavailability and short biological half-life. Drug delivery systems are very useful systems to overcome the difficulties associated with conventional dosage forms of metformin and also for its effective use in cancer treatment.

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“…6), which are close to the pK a2 value (11.5) of metformin. 52 As can be seen from Fig. 6, the I p increased with raising the solution pH so that the greatest I p value was obtained in the pH range of about 12.5-13.5.…”

Section: Effect Of Phmentioning

confidence: 77%

Determination of metformin at metal-organic framework (Cu-BTC) nanocrystals/multi-walled carbon nanotubes modified glassy carbon electrode

Hadi¹,

Poorgholi²,

Mostaanzadeh³

2016

S.Afr.j.chem.

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Glassy carbon (GC) electrode modified with Cu-based metal-organic frameworks (Cu-BTC, BTC = 1,3,5-benzenetricarboxylate) and multi-walled carbon nanotubes (CNTs) composites was developed. The Cu-BTCs were synthesized by two methods, traditional hydrothermal and ultrasonic irradiation methods. It was found that the Cu-BTC that was synthesized by the latter method, with mean crystallite sizes in the nanometers range, showed a higher impact on enhancing the electrocatalytic activity of the modified electrode toward the electro-oxidation of metformin compared to that synthesized with the former method with a larger crystallite size of micrometer-scale. The morphological characteristics of Cu-BTCs and Cu-BTC nanocrystals/CNTs modified GC electrode surface were characterized by scanning electron microscopy. The modified electrode showed excellent response of oxidation current for the determination of metformin. Under optimum conditions, the peak current showed good linearity with concentrations in the range of 0.5 µM to 25 µM and a detection limit of 0.12 µM, as well as good repeatability. The Cu-BTC nanocrystals/CNTs modified GC electrode was applied successfully to determine metformin in pharmaceutical samples with good accuracy. KEYWORDSMetal-organic framework, carbon nanotube, modified glassy carbon electrode, metformin, electroanalytical determination.

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Surfactant-Mediated Dissolution of Metformin Hydrochloride Tablets: Wetting Effects Versus Ion Pairs Diffusivity

Cited by 57 publications

References 20 publications

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Determination of metformin at metal-organic framework (Cu-BTC) nanocrystals/multi-walled carbon nanotubes modified glassy carbon electrode

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