Surfactant-free redispersible nanoparticles in fast-dissolving composite microcarriers for dry-powder inhalation

Lebhardt, Tobias; Roesler, Susanne; Uusitalo, Henna P.; Kissel, Thomas

doi:10.1016/j.ejpb.2010.12.002

Cited by 64 publications

(24 citation statements)

References 35 publications

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“…The droplets are cooled by solvent evaporation, due to the latent heat of vaporization and the product temperature in the co-current dryer is about 10-20 • C below the T out . Therefore, the co-current mode is preferable for drying of thermo-sensitive materials because the final product is in contact with the coolest air [28,53,57,58]. In this work, both the T in and the T out were below the T m of PCL and were sufficiently low to prevent ddI thermal degradation.…”

Section: Preparation and Characterization Of The Particlesmentioning

confidence: 95%

Spray-dried didanosine-loaded polymeric particles for enhanced oral bioavailability

Seremeta¹,

Tur²,

Pérez³

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Section: Preparation and Characterization Of The Particlesmentioning

confidence: 95%

Spray-dried didanosine-loaded polymeric particles for enhanced oral bioavailability

Seremeta¹,

Tur²,

Pérez³

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…However, nanosized particles have a low lung deposition and are more likely to be exhaled. Moreover, as a result of their size and high specific surface, nanoparticles show high surface energy that results in non-redispersible aggregates when they are dried (Lebhardt et al, 2011). Nanoparticles have to be administered after incorporation into larger structures with appropriate size for pulmonary drug delivery.…”

Section: Dry Powder Inhalersmentioning

confidence: 99%

“…Even if with pulmonary delivery high local concentrations can be achieved, they are often short-lived as the drug can be quickly removed from the lung through various clearance mechanisms, such as mucociliary clearance and reticuloendothelial system (RES) cells uptake. To improve the inhaled chemotherapy approach delivery systems able to enhance the treatment efficacy of the drug by increasing pulmonary residence time and reducing lung clearance, are needed (Lebhardt et al, 2011). At the same time some concerns have been raised about safety and organ toxicity of the treatment.…”

Section: Introductionmentioning

confidence: 99%

Loco-regional administration of nanomedicines for the treatment of lung cancer

et al. 2015

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Lung cancer poses one of the most significant challenges to modern medicine, killing thousands every year. Current therapy involves surgical resection supplemented with chemotherapy and radiotherapy due to high rates of relapse. Shortcomings of currently available chemotherapy protocols include unacceptably high levels of systemic toxicity and low accumulation of drug at the tumor site. Loco-regional delivery of nanocarriers loaded with anticancer agents has the potential to significantly increase efficacy, while minimizing systemic toxicity to anticancer agents. Local drug administration at the tumor site using nanoparticulate drug delivery systems can reduce systemic toxicities observed with intravenously administered anticancer drugs. In addition, this approach presents an opportunity for sustained delivery of anticancer drug over an extended period of time. Herein, the progress in the development of locally administered nanomedicines for the treatment of lung cancer is reviewed. Administration by inhalation, intratumoral injection and means of direct in situ application are discussed, the benefits and drawbacks of each modality are explored.

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“…However, to date, only recent work proposes such formulations, using only polymeric nanoparticles. [7][8][9] Although used as drug carriers, these polymeric nanoparticles present ongoing drawbacks due to the polymers themselves, which limit the drug encapsulation rates or leave polymeric residues in living tissues. The innovative concept of our work here is the creation of Trojan microparticles by spray-drying and encapsulation, not of polymeric nanoparticles but of nanoemulsions, which are fundamentally different systems.…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of nanoemulsions: novel Trojan particles for bioactive lipid molecule delivery

Li¹,

Anton²,

Ta³

et al. 2011

IJN

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Background Nanoemulsions consist of very stable nanodroplets of oil dispersed in an aqueous phase, typically below 300 nm in size. They can be used to obtain a very fine, homogeneous dispersion of lipophilic compounds in water, thus facilitating their handling and use in nanomedicine. However, the drawback is that they are suspended in an aqueous media. This study proposes a novel technique for drying lipid nanoemulsion suspensions to create so-called Trojan particles, ie, polymer microparticles (around 2 μm) which very homogeneously “entrap” the nano-oil droplets (around 150 nm) in their core. Methods Microencapsulation of the nanoemulsions was performed using a spray-drying process and resulted in a dried powder of microparticles. By using a low-energy nanoemulsification method and relatively gentle spray-drying, the process was well suited to sensitive molecules. The model lipophilic molecule tested was vitamin E acetate, encapsulated at around 20% in dried powder. Results We showed that the presence of nanoemulsions in solution before spray-drying had a significant impact on microparticle size, distribution, and morphology. However, the process itself did not destroy the oil nanodroplets, which could easily be redispersed when the powder was put back in contact with water. High-performance liquid chromatography follow-up of the integrity of the vitamin E acetate showed that the molecules were intact throughout the process, as well as when conserved in their dried form. Conclusion This study proposes a novel technique using a spray-drying process to microencapsulate nanoemulsions. The multiscale object formed, so-called Trojan microparticles, were shown to successfully encapsulate, protect, and release the lipid nanodroplets.

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Surfactant-free redispersible nanoparticles in fast-dissolving composite microcarriers for dry-powder inhalation

Cited by 64 publications

References 35 publications

Spray-dried didanosine-loaded polymeric particles for enhanced oral bioavailability

Spray-dried didanosine-loaded polymeric particles for enhanced oral bioavailability

Loco-regional administration of nanomedicines for the treatment of lung cancer

Microencapsulation of nanoemulsions: novel Trojan particles for bioactive lipid molecule delivery

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