Surfactant deficiency in full‐term newborns with transient tachypnea delivered by elective C‐section

Estorgato, Geovana Rhoden; Fiori, Humberto Holmer; Ribeiro, Manoel Antonio da Silva; Paula, Davi de; García, Pedro Celiny Ramos; Mattiello, Rita; Fiori, Renato Machado

doi:10.1002/ppul.23338

Cited by 9 publications

(3 citation statements)

References 25 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested that TTN and RDS form part of the same spectrum of disease process. Evidence suggests that full-term infants with TTN may have surfactant deficiency [ 52 ] and that antenatal maternal administration of corticosteroids may prevent TTN [ 53 , 54 ], adding weight to this claim. However, the different clinical course and distinct chest radiograph appearances are evidence for different disease processes.…”

Section: Common Conditions Primarily Seen In Term Infantsmentioning

confidence: 99%

Common respiratory conditions of the newborn

Gallacher

Hart

Kotecha

2016

Breathe

View full text Add to dashboard Cite

Key pointsRespiratory distress is a common presenting feature among newborn infants.Prompt investigation to ascertain the underlying diagnosis and appropriate subsequent management is important to improve outcomes.Many of the underlying causes of respiratory distress in a newborn are unique to this age group.A chest radiograph is crucial to assist in diagnosis of an underlying cause.Educational aimsTo inform readers of the common respiratory problems encountered in neonatology and the evidence-based management of these conditions.To enable readers to develop a framework for diagnosis of an infant with respiratory distress.The first hours and days of life are of crucial importance for the newborn infant as the infant adapts to the extra-uterine environment. The newborn infant is vulnerable to a range of respiratory diseases, many unique to this period of early life as the developing fluid-filled fetal lungs adapt to the extrauterine environment. The clinical signs of respiratory distress are important to recognise and further investigate, to identify the underlying cause. The epidemiology, diagnostic features and management of common neonatal respiratory conditions are covered in this review article aimed at all healthcare professionals who come into contact with newborn infants.

show abstract

Section: Common Conditions Primarily Seen In Term Infantsmentioning

confidence: 99%

Common respiratory conditions of the newborn

Gallacher

Hart

Kotecha

2016

Breathe

View full text Add to dashboard Cite

show abstract

“…A similar study was done by Fiori et al [ 15 ] and deficiency or dysfunction of the surfactant system is involved in the majority of cases of respiratory distress in near term and possibly term infants. In another study which 544 infants were born to via elective cesarean delivery examined and oral fluid samples were obtained in the delivery room immediately after birth, and gastric fluid was collected within the first hour of life [ 16 ]. They suggest that TTN was associated with surfactant dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Can surfactants affect mortality and morbidity in term infants with respiratory failure?

ÖZDEMİR¹,

YILMAN²,

ÇALKAVUR³

et al. 2022

Turkish Journal of Medical Sciences

View full text Add to dashboard Cite

Background/aim We aimed to discuss term infants who are given surfactant due to respiratory disorder according to the underlying etiology, the dose of surfactant administration, and the need for repeated surfactant administration. Materials and methods In this retrospective study infants hospitalized in the 4th level neonatal intensive care unit during January 2019 and December 2021 and administered surfactant due to respiratory distress were included. Term infants given surfactant due to respiratory failure were included in the study through the data recording system. The number of surfactant doses, indications for administration, mortality, duration of hospitalization, intubation time, and inotrope use were recorded in the infants included in the study. Results During the two-year period, 1250 infants were hospitalized in our neonatal intensive care unit. Of those, 56 infants received surfactant replacement therapy for severe respiratory failure. There were 30 infants with pneumonia, 4 infants with meconium aspiration syndrome (MAS), and 22 infants with transient tachypnea of the newborn (TTN). It was seen that single-dose administration was higher in patients with TTN (p = 0.01), while multiple-dose surfactant administration was more common in patients with MAS, resulting in a statistical difference (p = 0.02). Mortality was lower, especially in cases given early surfactant administration and this situation was statistically significant (p < 0.001). Duration of intubation was 5.05 ± 4.7 days in early surfactant administration group and 8.0 ± 6.1 days in late surfactant administration group. This difference was statistically significant (p = 0.04). While early surfactant application was statistically higher in the TTN group (p = 0.007), late surfactant application was statistically higher in the pneumonia group (p = 0.001). Conclusion Despite the difference on administration time and repeat dose interval due to etiology, surfactant treatment is improving the respiratory distress of term infants.

show abstract

“…1 In newborns, World Health Organization(WHO) declares tachypnea as a respiratory rate of more than 60/minute. 2 Transient tachypnea of the newborn (TTN) is a common differential in any newborn who develops respiratory distress immediately after birth at term gestation. One-third of the newborns hospitalized due to respiratory distress are ultimately diagnosed with TTN.…”

Section: Introductionmentioning

confidence: 99%

Role of Salbutamol in The Management of Transient Tachypnea of the Newborn: A Comparative Prospective Study

Ahmed

Tahir²,

Subhani³

et al. 2022

PAFMJ

View full text Add to dashboard Cite

Objective: To compare the outcome of Salbutamol nebulization with normal saline (placebo) in transient tachypnea of the newborn. Study Design: Comparative prospective study. Place and Duration of Study: Department of Neonatal Medicine, Military Hospital Rawalpindi, from Jan 2017 to Mar 2018. Methodology: Sixty term neonates with respiratory rate >60 breaths/min and transient tachypnea of newborn score of ≥4 were enrolled. They were randomly allocated to two equal groups. Group-1 received Salbutamol nebulization (0.15 mg/kg) while Group-2 received normal Saline (placebo) nebulization. Results: The mean gestational age was 38.31±1.28 weeks, while the average birth weight was 2.97±0.27 kg. The mean change in transient tachypnea of newborn score with Salbutamol nebulization was 5.63±1.22, while 0.63±1.54 with normal Saline nebulization. Likewise, the mean change in respiratory rate with Salbutamol was 9.80±2.05, while -3.73±2.57 with normal saline. Conclusion: This study demonstrated nebulized Salbutamol as an effective tool in reversing transient tachypnea of newborns with decreasing respiratory rate compared to normal saline nebulization (placebo).

show abstract

Surfactant deficiency in full‐term newborns with transient tachypnea delivered by elective C‐section

Abstract: The present results suggest that transient tachypnea of the newborn is associated with surfactant dysfunction. Pediatr Pulmonol. 2016;51:596-600. © 2015 Wiley Periodicals, Inc.

Cited by 9 publications

References 25 publications

Common respiratory conditions of the newborn

Common respiratory conditions of the newborn

Can surfactants affect mortality and morbidity in term infants with respiratory failure?

Role of Salbutamol in The Management of Transient Tachypnea of the Newborn: A Comparative Prospective Study

Contact Info

Product

Resources

About