Surfactant and Perfluorocarbon Aerosolization by Means of Inhalation Catheters for the Treatment of Respiratory Distress Syndrome: An <i>In Vitro</i> Study

Murgia, Xabier; Gastiasoro, Elena; Mielgo, Victoria; Alvarez-Diaz, F.; Lafuente, Héctor; Valls‐i‐Soler, Adolf; Gomez-Solaetxe, Miguel Angel; Larrabe, Juan Luís; Rey-Santano, Carmen

doi:10.1089/jamp.2010.0831

Cited by 15 publications

(29 citation statements)

References 30 publications

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“…On the other hand, a shorter PFD aerosolization time was needed to improve lung mechanics; C dyn significantly had already improved in the PFC aerosol group by 30 min after the initiation of the therapy. On the basis of our bench studies (14,21), at 30 min of therapy, a PFD dose of ~3-3.5 ml/kg would have effectively reached the lung, which corresponds to the minimal dose of PFC to significantly improve C dyn according to Tütüncu et al (9).…”

Section: Discussionmentioning

confidence: 80%

“…The lack of efficacy of aerosolized PFC shown by Kelly et al (12) in surfactant-depleted rabbits contrasts with the overwhelmingly beneficial results reported by Kandler et al (1) in surfactant-depleted piglets, with PFC delivered as an aerosol being better than PLV. The inconsistent results of these studies could be related to differences in the type of animal model and degree of injury, aerosol therapy devices (13), and the biophysical properties of the type of PFC used (14,16).…”

Section: Discussionmentioning

confidence: 99%

“…For this study, an inhalation catheter (1,14) placed into the endotracheal tube was used to produce PFD aerosols, with its aerosol generating tip placed above the carina. As compared with previous devices used to aerosolize PFC (12,15), this system bypasses the oropharynx, avoiding the high deposition that tends to occur within the endotracheal tube (18).…”

Section: Discussionmentioning

confidence: 99%

“…As compared with previous devices used to aerosolize PFC (12,15), this system bypasses the oropharynx, avoiding the high deposition that tends to occur within the endotracheal tube (18). Therefore, particles >5 µm can reach the lungs and have a therapeutic effect (14). We hypothesize that the larger PFD particles (with an aerodynamic diameter >5 µm) deposited Articles Murgia et al…”

Section: Discussionmentioning

confidence: 99%

“…To date, however, the experimental results on PFC aerosolization remain controversial, varying from no effect at all (12), to better pulmonary response to aerosolized PFC than to PLV (1). Such inconsistency might be partially explained by differences in aerosol devices (13), the biophysical properties of PFCs (13,14), the time of aerosolization, and the degree of lung injury of the animal model used.…”

mentioning

confidence: 99%

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Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome

et al. 2012

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Background: aerosolized perfluorocarbon (PFc) has been proposed as an alternative method of PFc administration; however, the efficacy of aerosolized PFc in a preterm animal model has not yet been demonstrated. Methods: Twelve preterm lambs were randomized to two groups: a perfluorodecalin (PFD) aerosol group (n = 6) receiving 10 ml/kg/h of PFD delivered by an intratracheal inhalation catheter followed by 4 h of mechanical ventilation (MV) or the control group, in which animals (n = 6) were managed for 6 h with MV. Gas exchange, pulmonary mechanics, cardiovascular parameters, and cerebral blood flow (cBF) were measured. results: Both groups developed hypoxia, hypercarbia, and acidosis at baseline. aerosolized PFD improved oxygenation (P < 0.0001) and pulmonary mechanics (P < 0.0001) and changed carbon dioxide values to normal physiological levels, unlike the treatment given to the controls (P < 0.0003). The time course of mean arterial blood pressure and cBF were significantly affected by PFD aerosolization, especially during the first hour of life. cBF gradually decreased during the first hour in the PFD aerosol group and remained stable until the end of the follow-up, whereas cBF remained higher in the control group (P < 0.0028). conclusion: aerosolized PFD improves pulmonary function in preterm lambs and should be further investigated as an alternative mode of PFc administration.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome

et al. 2012

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Aerosolized semifluorinated alkanes as excipients are suitable for inhalative drug delivery—A pilot study

Tsagogiorgas

Jung

Krebs

et al. 2012

International Journal of Pharmaceutics

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Identification of Stable Perfluorocarbons Formed by Hyperthermal Decomposition of Graphite Fluoride Using Anion Photoelectron Spectroscopy

2022

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Anion photoelectron (PE) spectroscopy was used to characterize several perfluorocarbon (PFC) species generated from pulsed-laser ablation of graphite fluoride (GF) and compare them to PFCs introduced into the gas phase and negatively charged by using a gentle photoemission source. The PE spectra of C6F6 –, C7F8 –, and C5F8 – produced by ablation of GF are nearly identical with the PE spectra of the anions of hexafluorobenzene, perfluorotoluene, and perfluorocyclopentene, respectively, generated by electron attachment to the neutral perfluorocarbon molecules. This result suggests that laser ablation of GF, which is a hyperthermal decomposition event, produces species larger than CF2 and with stable molecular structures. In addition, anion PE spectra were obtained for several larger PFC molecular anions, some of which have been the subject of past computational studies. The electron affinities of these species cannot be determined unambiguously from the broad PE spectra, though a systematic approach to identifying the onset of detachment signal was used to approximate the electron affinities. The vertical detachment energy of perfluoroethylcyclohexene was determined to be 2.98 ± 0.05 eV. The vertical detachment energies of additional perfluorocarbon radical anions, including perfluoroheptene, perfluoromethylcyclohexane, perfluoro-1,3-dimethylcyclohexane, and perfluorodecalin, all exceed 3.495 eV. We also demonstrated that photoemission from gadolinia (Gd2O3) using a pulsed laser is an efficient and effective method of generating radical anions of larger volatile molecules in the gas phase.

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Surfactant and Perfluorocarbon Aerosolization by Means of Inhalation Catheters for the Treatment of Respiratory Distress Syndrome: An In Vitro Study

Cited by 15 publications

References 30 publications

Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome

Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome

Aerosolized semifluorinated alkanes as excipients are suitable for inhalative drug delivery—A pilot study

Identification of Stable Perfluorocarbons Formed by Hyperthermal Decomposition of Graphite Fluoride Using Anion Photoelectron Spectroscopy

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